Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand

Detalhes bibliográficos
Autor(a) principal: Pereira-da-Silva, Tiago
Data de Publicação: 2020
Outros Autores: Napoleão, Patricia, Pinheiro, Teresa, Selas, Mafalda, Silva, Filipa, Ferreira, Rui Cruz, Carmo, Miguel Mota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47313
Resumo: AJCD Copyright © 2020
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spelling Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligandChronic coronary syndromeCoronary artery diseaseInflammationSoluble CD40 ligandAJCD Copyright © 2020Introduction: Inflammation contributes to the initiation and progression of atherosclerosis, although the underlying inflammatory pathways are not entirely known. Specifically, the role of the proinflammatory soluble CD40 ligand (sCD40L) on the expression of chronic coronary syndrome (CCS) is not completely understood. We evaluated whether sCD40L expression is associated with the presence of CCS and with the clinical and anatomical severity of CCS. Methods: We prospectively recruited 94 participants, assigned to two groups matched by age and sex, without coronary artery disease (n=26) and with CCS (n=68). Clinical, laboratory and anatomical data were prospectively collected, and serum levels of sCD40L were measured. Results: In patients with CCS, classic cardiovascular risk factors were more prevalent, and the sCD40L levels, leukocyte and neutrophil counts, and neutrophil/lymphocyte ratio, but not the C-reactive protein levels, were significantly higher than those in controls. sCD40L was independently associated with the presence of obstructive coronary artery disease in multivariate analysis. Regarding CCS severity, sCD40L levels showed a significant stepwise increase with increasing angina severity (ANOVA P=0.001). In addition, sCD40L was independently associated with the anatomical severity of coronary artery disease, as assessed by the Gensini score. Among patients with CCS, those with previous coronary artery bypass grafting (n=23) had lower sCD40L levels than patients waiting for revascularization (n=45) [4.3 (2.1) ng/mL vs. 6.8 (3.5) ng/mL, P=0.001]. Conclusions: The expression of the proinflammatory sCD40L was associated with the presence of CCS and reflected the clinical and anatomical severity of CCS. In addition, we describe for the first time the association between prior CABG and reduced sCD40L levels in patients with CCS.e-Century Publishing CorporationRepositório da Universidade de LisboaPereira-da-Silva, TiagoNapoleão, PatriciaPinheiro, TeresaSelas, MafaldaSilva, FilipaFerreira, Rui CruzCarmo, Miguel Mota2021-04-09T12:50:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47313engAm J Cardiovasc Dis. 2020 Oct 15;10(4):329-3392160-200Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:09Zoai:repositorio.ul.pt:10451/47313Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:23.480996Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
spellingShingle Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
Pereira-da-Silva, Tiago
Chronic coronary syndrome
Coronary artery disease
Inflammation
Soluble CD40 ligand
title_short Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_full Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_fullStr Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_full_unstemmed Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_sort Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
author Pereira-da-Silva, Tiago
author_facet Pereira-da-Silva, Tiago
Napoleão, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author_role author
author2 Napoleão, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira-da-Silva, Tiago
Napoleão, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Chronic coronary syndrome
Coronary artery disease
Inflammation
Soluble CD40 ligand
topic Chronic coronary syndrome
Coronary artery disease
Inflammation
Soluble CD40 ligand
description AJCD Copyright © 2020
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-09T12:50:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47313
url http://hdl.handle.net/10451/47313
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Am J Cardiovasc Dis. 2020 Oct 15;10(4):329-339
2160-200X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing Corporation
publisher.none.fl_str_mv e-Century Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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