Decoy activity through microRNAs : the therapeutic implications

Detalhes bibliográficos
Autor(a) principal: Almeida, Maria Inês
Data de Publicação: 2012
Outros Autores: Reis, R. M., Calin, George A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/23786
Resumo: Introduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5´UTR, coding regions or 3´UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA--RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.
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spelling Decoy activity through microRNAs : the therapeutic implicationsMimicRegulationSpongeTherapeutic potentialScience & TechnologyIntroduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5´UTR, coding regions or 3´UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA--RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.M.I.A. is supported by a PhD fellowship (SFRH/BD/47031/2008) from Fundacão para a Ciência e Tecnologia, Portugal. Dr. Calin is The Alan M. Gewirtz Leukemia & Lymphoma Society Scholar. He is also supported as a Fellow at The University of Texas MD Anderson Research Trust, as a University of Texas System Regents Research Scholar, and by the CLL Global Research Foundation. Work in Dr. Calin’s laboratory is supported in part by an NIH/NCI grant (CA135444), a Department of Defense Breast Cancer Idea Award, Developmental Research Awards in Breast Cancer, Ovarian Cancer, Brain Cancer, Prostate Cancer, Multiple Myeloma, and Leukemia SPOREs, the Laura and John Arnold Foundation, the RGK Foundation and the Estate of C. G. Johnson, Jr. The authors disclose no conflicts of interests and no funding was received in preparation of this manuscript.Informa HealthcareUniversidade do MinhoAlmeida, Maria InêsReis, R. M.Calin, George A.2012-092012-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23786eng1471-259810.1517/14712598.2012.69347022650365http://informahealthcare.com/doi/abs/10.1517/14712598.2012.693470info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:31:54Zoai:repositorium.sdum.uminho.pt:1822/23786Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:27:11.908952Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Decoy activity through microRNAs : the therapeutic implications
title Decoy activity through microRNAs : the therapeutic implications
spellingShingle Decoy activity through microRNAs : the therapeutic implications
Almeida, Maria Inês
Mimic
Regulation
Sponge
Therapeutic potential
Science & Technology
title_short Decoy activity through microRNAs : the therapeutic implications
title_full Decoy activity through microRNAs : the therapeutic implications
title_fullStr Decoy activity through microRNAs : the therapeutic implications
title_full_unstemmed Decoy activity through microRNAs : the therapeutic implications
title_sort Decoy activity through microRNAs : the therapeutic implications
author Almeida, Maria Inês
author_facet Almeida, Maria Inês
Reis, R. M.
Calin, George A.
author_role author
author2 Reis, R. M.
Calin, George A.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Almeida, Maria Inês
Reis, R. M.
Calin, George A.
dc.subject.por.fl_str_mv Mimic
Regulation
Sponge
Therapeutic potential
Science & Technology
topic Mimic
Regulation
Sponge
Therapeutic potential
Science & Technology
description Introduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5´UTR, coding regions or 3´UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covered: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA--RNA language that involves crosstalk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. Expert opinion: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
2012-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/23786
url http://hdl.handle.net/1822/23786
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2598
10.1517/14712598.2012.693470
22650365
http://informahealthcare.com/doi/abs/10.1517/14712598.2012.693470
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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