Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

Detalhes bibliográficos
Autor(a) principal: Melo, Bernardete F.
Data de Publicação: 2021
Outros Autores: Prieto-Lloret, Jesus, Cabral, Marlene D., Martins, Fatima O., Martins, Inês B., Sacramento, Joana F., Ruivo, Pedro, Carvalho, Tânia, Conde, Silvia V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/115150
Resumo: Funding: B.F.M. is supported by PhD Grant from Portuguese Foundation for Science and Technology Reference PD/BD/128336/2017. FOM and JFS are supported by Portuguese Foundation for Science and Technology contracts CEECIND/04266/2017 and CEECIND/02428/2018
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary arteryGeneralSDG 3 - Good Health and Well-beingFunding: B.F.M. is supported by PhD Grant from Portuguese Foundation for Science and Technology Reference PD/BD/128336/2017. FOM and JFS are supported by Portuguese Foundation for Science and Technology contracts CEECIND/04266/2017 and CEECIND/02428/2018Type 2 diabetes (T2D) is associated with cardiovascular and pulmonary disease. How T2D affects pulmonary endothelial function is not well characterized. We investigated the effects of T2D progression on contractility machinery and endothelial function in the pulmonary and systemic circulation and the mechanisms promoting the dysfunction, using pulmonary artery (PA) and aorta. A high-fat (HF, 3 weeks 60% lipid-rich diet) and a high-fat/high-sucrose (HFHSu, combined 60% lipid-rich diet and 35% sucrose during 25 weeks) groups were used as prediabetes and T2D rat models. We found that T2D progression differently affects endothelial function and vascular contractility in the aorta and PA, with the contractile machinery being altered in the PA and aorta in prediabetes and T2D animals; and endothelial function being affected in both models in the aorta but only affected in the PA of T2D animals, meaning that PA is more resistant than aorta to endothelial dysfunction. Additionally, PA and systemic endothelial dysfunction in diabetic rats were associated with alterations in the nitrergic system and inflammatory pathways. PA dysfunction in T2D involves endothelial wall mineralization. The understanding of the mechanisms behind PA dysfunction in T2D can lead to significant advances in both preventative and therapeutic treatments of pulmonary disease-associated diabetes.iNOVA4Health - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMelo, Bernardete F.Prieto-Lloret, JesusCabral, Marlene D.Martins, Fatima O.Martins, Inês B.Sacramento, Joana F.Ruivo, PedroCarvalho, TâniaConde, Silvia V.2021-04-07T22:16:21Z2021-03-152021-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/115150eng2045-2322PURE: 28923088https://doi.org/10.1038/s41598-021-85606-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:57:49Zoai:run.unl.pt:10362/115150Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:42.144030Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
spellingShingle Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
Melo, Bernardete F.
General
SDG 3 - Good Health and Well-being
title_short Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_fullStr Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_full_unstemmed Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
title_sort Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery
author Melo, Bernardete F.
author_facet Melo, Bernardete F.
Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
author_role author
author2 Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv iNOVA4Health - pólo NMS
Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Melo, Bernardete F.
Prieto-Lloret, Jesus
Cabral, Marlene D.
Martins, Fatima O.
Martins, Inês B.
Sacramento, Joana F.
Ruivo, Pedro
Carvalho, Tânia
Conde, Silvia V.
dc.subject.por.fl_str_mv General
SDG 3 - Good Health and Well-being
topic General
SDG 3 - Good Health and Well-being
description Funding: B.F.M. is supported by PhD Grant from Portuguese Foundation for Science and Technology Reference PD/BD/128336/2017. FOM and JFS are supported by Portuguese Foundation for Science and Technology contracts CEECIND/04266/2017 and CEECIND/02428/2018
publishDate 2021
dc.date.none.fl_str_mv 2021-04-07T22:16:21Z
2021-03-15
2021-03-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/115150
url http://hdl.handle.net/10362/115150
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 28923088
https://doi.org/10.1038/s41598-021-85606-7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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