Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Detalhes bibliográficos
Autor(a) principal: Bousquet, Jean
Data de Publicação: 2023
Outros Autores: Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/13302
Resumo: Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.
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spelling Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesisAsthmaToll-like receptorsMultimorbidityRhinitisIL-33Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.uBibliorumBousquet, JeanMelén, ErikHaahtela, TariKoppelman, GerardTogias, AlkisValenta, RudolfAkdis, CezmiCzarlewski, WienczyslawaRothenberg, MarcValiulis, ArunasWickman, MagnusVichyanond, PakitMoniuszko, MarcinĖmužytė, ReginaBush, AndrewChu, Derek KViegi, GiovanniWallace, DanaDurham, StephenWang, De YunVandenplas, O.Just, JocelyneCarlsen, Karin C. LodrupPassalacqua, GiovanniWilliams, SiânLinnemann, Désirée LarenasLoureiro, Cláudia ChavesSagara, HironoriWorm, MargittaYiallouros, PanayiotisYusuf, OsmanZaitoun, FaresBonini, MatteoHrubiško, MartinCingi, C.Dykewicz, MarkZernotti, MarioCalderon, MoisesHalpin, David M.G.Zidarn, MihaelaPatella, VincenzoSheikh, AzizZuberbier, JaronPapadopoulos, NikolaosLouis, RenaudSuppli Ulrik, CharlotteFonseca, João P.Zuberbier, TorstenAnto, M. J.Costa, ElisioEiwegger, ThomasBosnic-Anticevich, SinthiaCruz, AlvaroSousa, Jaime Correia deLouis-Philippe, BouletErhola, MarinaCardona, VictoriaCarr, WarnerGemicioglu, BilunPawankar, RubyFokkens, WytskeCalvo, MárioGarcia-Aymerich, J.Mäkelä, Mika J.Hofmann, Maja AnnKlimek, LudgerMakris, MichaelMohamed Sayed, ZeinabMaurer, MarcusD'Amato, G.Momas, IsabelleSiroux, ValérieAlmeida, Mário MoraisCorrigan, ChrisMullol, JoaquimMontefort, StephenJutel, MarekPham Thi, NhanHossny, ElhamAkdis, MubeccelPfaar, OliverVentura, Maria TeresaRegateiro, Frederico S.Bindslev-Jensen, CarstenRing, JohannesBustamante, MarionaPinto, Bernardo SousaKaidashev, IgorGuerra, StefanoStandl, MarieSunyer, J.Keil, ThomasBarata, Luís TabordaCamargos, PauloWeiss, ScottNaclerio, RobertYorgancıoglu, ArzuZhang, LuoNadeau, KariAbdul Latiff, AmirAberer, WernerHeinrich, JoachimSisul, JuanNunes, ElizabetePlavec, DavorAgache, IoanaAl-Ahmad, MonaSerpa, FaradibaAlobid, IsamKalayci, OmerGiacco, S. DelFiocchi, AlessandroAnsotegui Zubeldia, Ignacio JavierCustovic, AdnanMartins, Pedro CarreiroRouadi, PhilipArshad, Syed HasanAsayag, EstrellaBárbara, CristinaAbdullah, BaharudinTomazic, Peter ValentinPopov, T. A.Sayah, ZinebLkhagvaa, BatturNyembue Tshipukane , DieudonneThomas, MikeBennoor, Kazi SaifuddinFyhrquist, Nanna TheresiaIrani, CarlaBerghea, Elena CameliaDe Blay, FrédéricToppila-Salmi, Sanna KatriinaBergmann, Karl-ChristianBernstein, D.Bewick, M.Casale, ThomasScheire, SophieBumbacea, Roxana SilviaCepeda Sarabia, AlfonsoPuggioni, FrancescaChandrasekharan, RamanathanOhta, KenOkubo, KimihiroCharpin, DenisGomez, R MaximilianoChen, Y. Z.O'Hehir, RobynCherrez Ojeda, IvanBedbrook, AnnaTo, TeresaDevillier, PhilippeSchmid-Grendelmeier, PeterDidier, AlainRepka-Ramirez, María SusanaTeixeira, Maria Do CéuIspayeva, ZhanatDokic, DejanQuirce, SantiagoDouagui , HabibIvancevich, Juan CarlosGotua, MaiaTodo-Bom, AnaBlain, HubertGuzman, Maria AntonietaKalyoncu, Ali FuatHagemann, JanBuhl, RolandHamamah, SamirCaraballo, LuisJares, EdgardoChivato, TomásJartti, TuomasJassem, EwaChristoff, GeorgeJulge, KalevOgulur, IsmailKardas, PrzemyslawDoulaptsi, MariaKirenga, BruceHelga, KraxnerKull, IngerKulus, MarekDaniel, AguilarShamji, MohamedKuna, PiotrNadif, RachelLa Grutta, StefaniaBrightling, ChrisSamoliński, BolesławLau, SusanneCordeiro, Carlos Manuel Da Silva RobaloSolé, DirceuLe Thi Tuyet, LanRecto, MarysiaOuedraogo, SolangeHalken, SusanneLevin, MichaelLipworth, BrianLourenço, OlgaMahboub, BassamNiedoszytko, MarekSastre, JoaquinMartinez‐Infante, E.Kupczyk, MaciejTorres, María JoseMatricardi, Paolo MariaCecchi, LorenzoCeledón, Juan CMiculinic, NevenRoche, NicolasMigueres, NicolasBrussino, LuisaFlorin, MihaltanOlze, HeidiSavouré, MarineNekam, KristofPali, IsabellaOkamoto, YoshitakaPalomares, O.Lemonnier, NathanaëlPalosuo, KatiSoto-Martinez, ManuelPanaitescu, CarmenKvedarienė, VioletaPanzner, P.Braido, FulvioTsiligianni, IoannaRodriguez-Gonzalez, MonicaScichilone, NicolaCanonica, Giogio WalterRomantowski, JanUrrutia-Pereira, MarilynFilho, Nelson Augusto RosarioOllert, Markus W.Rottem, MenachemChkhartishvili, EkaterineSova, MilanValovirta, ErkkaMohammad, YousserSperl, AnnetteSpranger, OttoNeffen, HugoStelmach, RafaelBurte, EmilieValentin Rostan, MarylinPark, Hae-SimVan Ganse, EricVan Hage, MariannePitsios, ConstantinosVasankari, Tuula2023-04-21T15:55:25Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/13302eng10.1111/all.15679info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:56:48Zoai:ubibliorum.ubi.pt:10400.6/13302Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:52:46.196508Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
title Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
spellingShingle Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
Bousquet, Jean
Asthma
Toll-like receptors
Multimorbidity
Rhinitis
IL-33
title_short Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
title_full Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
title_fullStr Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
title_full_unstemmed Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
title_sort Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
author Bousquet, Jean
author_facet Bousquet, Jean
Melén, Erik
Haahtela, Tari
Koppelman, Gerard
Togias, Alkis
Valenta, Rudolf
Akdis, Cezmi
Czarlewski, Wienczyslawa
Rothenberg, Marc
Valiulis, Arunas
Wickman, Magnus
Vichyanond, Pakit
Moniuszko, Marcin
Ėmužytė, Regina
Bush, Andrew
Chu, Derek K
Viegi, Giovanni
Wallace, Dana
Durham, Stephen
Wang, De Yun
Vandenplas, O.
Just, Jocelyne
Carlsen, Karin C. Lodrup
Passalacqua, Giovanni
Williams, Siân
Linnemann, Désirée Larenas
Loureiro, Cláudia Chaves
Sagara, Hironori
Worm, Margitta
Yiallouros, Panayiotis
Yusuf, Osman
Zaitoun, Fares
Bonini, Matteo
Hrubiško, Martin
Cingi, C.
Dykewicz, Mark
Zernotti, Mario
Calderon, Moises
Halpin, David M.G.
Zidarn, Mihaela
Patella, Vincenzo
Sheikh, Aziz
Zuberbier, Jaron
Papadopoulos, Nikolaos
Louis, Renaud
Suppli Ulrik, Charlotte
Fonseca, João P.
Zuberbier, Torsten
Anto, M. J.
Costa, Elisio
Eiwegger, Thomas
Bosnic-Anticevich, Sinthia
Cruz, Alvaro
Sousa, Jaime Correia de
Louis-Philippe, Boulet
Erhola, Marina
Cardona, Victoria
Carr, Warner
Gemicioglu, Bilun
Pawankar, Ruby
Fokkens, Wytske
Calvo, Mário
Garcia-Aymerich, J.
Mäkelä, Mika J.
Hofmann, Maja Ann
Klimek, Ludger
Makris, Michael
Mohamed Sayed, Zeinab
Maurer, Marcus
D'Amato, G.
Momas, Isabelle
Siroux, Valérie
Almeida, Mário Morais
Corrigan, Chris
Mullol, Joaquim
Montefort, Stephen
Jutel, Marek
Pham Thi, Nhan
Hossny, Elham
Akdis, Mubeccel
Pfaar, Oliver
Ventura, Maria Teresa
Regateiro, Frederico S.
Bindslev-Jensen, Carsten
Ring, Johannes
Bustamante, Mariona
Pinto, Bernardo Sousa
Kaidashev, Igor
Guerra, Stefano
Standl, Marie
Sunyer, J.
Keil, Thomas
Barata, Luís Taborda
Camargos, Paulo
Weiss, Scott
Naclerio, Robert
Yorgancıoglu, Arzu
Zhang, Luo
Nadeau, Kari
Abdul Latiff, Amir
Aberer, Werner
Heinrich, Joachim
Sisul, Juan
Nunes, Elizabete
Plavec, Davor
Agache, Ioana
Al-Ahmad, Mona
Serpa, Faradiba
Alobid, Isam
Kalayci, Omer
Giacco, S. Del
Fiocchi, Alessandro
Ansotegui Zubeldia, Ignacio Javier
Custovic, Adnan
Martins, Pedro Carreiro
Rouadi, Philip
Arshad, Syed Hasan
Asayag, Estrella
Bárbara, Cristina
Abdullah, Baharudin
Tomazic, Peter Valentin
Popov, T. A.
Sayah, Zineb
Lkhagvaa, Battur
Nyembue Tshipukane , Dieudonne
Thomas, Mike
Bennoor, Kazi Saifuddin
Fyhrquist, Nanna Theresia
Irani, Carla
Berghea, Elena Camelia
De Blay, Frédéric
Toppila-Salmi, Sanna Katriina
Bergmann, Karl-Christian
Bernstein, D.
Bewick, M.
Casale, Thomas
Scheire, Sophie
Bumbacea, Roxana Silvia
Cepeda Sarabia, Alfonso
Puggioni, Francesca
Chandrasekharan, Ramanathan
Ohta, Ken
Okubo, Kimihiro
Charpin, Denis
Gomez, R Maximiliano
Chen, Y. Z.
O'Hehir, Robyn
Cherrez Ojeda, Ivan
Bedbrook, Anna
To, Teresa
Devillier, Philippe
Schmid-Grendelmeier, Peter
Didier, Alain
Repka-Ramirez, María Susana
Teixeira, Maria Do Céu
Ispayeva, Zhanat
Dokic, Dejan
Quirce, Santiago
Douagui , Habib
Ivancevich, Juan Carlos
Gotua, Maia
Todo-Bom, Ana
Blain, Hubert
Guzman, Maria Antonieta
Kalyoncu, Ali Fuat
Hagemann, Jan
Buhl, Roland
Hamamah, Samir
Caraballo, Luis
Jares, Edgardo
Chivato, Tomás
Jartti, Tuomas
Jassem, Ewa
Christoff, George
Julge, Kalev
Ogulur, Ismail
Kardas, Przemyslaw
Doulaptsi, Maria
Kirenga, Bruce
Helga, Kraxner
Kull, Inger
Kulus, Marek
Daniel, Aguilar
Shamji, Mohamed
Kuna, Piotr
Nadif, Rachel
La Grutta, Stefania
Brightling, Chris
Samoliński, Bolesław
Lau, Susanne
Cordeiro, Carlos Manuel Da Silva Robalo
Solé, Dirceu
Le Thi Tuyet, Lan
Recto, Marysia
Ouedraogo, Solange
Halken, Susanne
Levin, Michael
Lipworth, Brian
Lourenço, Olga
Mahboub, Bassam
Niedoszytko, Marek
Sastre, Joaquin
Martinez‐Infante, E.
Kupczyk, Maciej
Torres, María Jose
Matricardi, Paolo Maria
Cecchi, Lorenzo
Celedón, Juan C
Miculinic, Neven
Roche, Nicolas
Migueres, Nicolas
Brussino, Luisa
Florin, Mihaltan
Olze, Heidi
Savouré, Marine
Nekam, Kristof
Pali, Isabella
Okamoto, Yoshitaka
Palomares, O.
Lemonnier, Nathanaël
Palosuo, Kati
Soto-Martinez, Manuel
Panaitescu, Carmen
Kvedarienė, Violeta
Panzner, P.
Braido, Fulvio
Tsiligianni, Ioanna
Rodriguez-Gonzalez, Monica
Scichilone, Nicola
Canonica, Giogio Walter
Romantowski, Jan
Urrutia-Pereira, Marilyn
Filho, Nelson Augusto Rosario
Ollert, Markus W.
Rottem, Menachem
Chkhartishvili, Ekaterine
Sova, Milan
Valovirta, Erkka
Mohammad, Yousser
Sperl, Annette
Spranger, Otto
Neffen, Hugo
Stelmach, Rafael
Burte, Emilie
Valentin Rostan, Marylin
Park, Hae-Sim
Van Ganse, Eric
Van Hage, Marianne
Pitsios, Constantinos
Vasankari, Tuula
author_role author
author2 Melén, Erik
Haahtela, Tari
Koppelman, Gerard
Togias, Alkis
Valenta, Rudolf
Akdis, Cezmi
Czarlewski, Wienczyslawa
Rothenberg, Marc
Valiulis, Arunas
Wickman, Magnus
Vichyanond, Pakit
Moniuszko, Marcin
Ėmužytė, Regina
Bush, Andrew
Chu, Derek K
Viegi, Giovanni
Wallace, Dana
Durham, Stephen
Wang, De Yun
Vandenplas, O.
Just, Jocelyne
Carlsen, Karin C. Lodrup
Passalacqua, Giovanni
Williams, Siân
Linnemann, Désirée Larenas
Loureiro, Cláudia Chaves
Sagara, Hironori
Worm, Margitta
Yiallouros, Panayiotis
Yusuf, Osman
Zaitoun, Fares
Bonini, Matteo
Hrubiško, Martin
Cingi, C.
Dykewicz, Mark
Zernotti, Mario
Calderon, Moises
Halpin, David M.G.
Zidarn, Mihaela
Patella, Vincenzo
Sheikh, Aziz
Zuberbier, Jaron
Papadopoulos, Nikolaos
Louis, Renaud
Suppli Ulrik, Charlotte
Fonseca, João P.
Zuberbier, Torsten
Anto, M. J.
Costa, Elisio
Eiwegger, Thomas
Bosnic-Anticevich, Sinthia
Cruz, Alvaro
Sousa, Jaime Correia de
Louis-Philippe, Boulet
Erhola, Marina
Cardona, Victoria
Carr, Warner
Gemicioglu, Bilun
Pawankar, Ruby
Fokkens, Wytske
Calvo, Mário
Garcia-Aymerich, J.
Mäkelä, Mika J.
Hofmann, Maja Ann
Klimek, Ludger
Makris, Michael
Mohamed Sayed, Zeinab
Maurer, Marcus
D'Amato, G.
Momas, Isabelle
Siroux, Valérie
Almeida, Mário Morais
Corrigan, Chris
Mullol, Joaquim
Montefort, Stephen
Jutel, Marek
Pham Thi, Nhan
Hossny, Elham
Akdis, Mubeccel
Pfaar, Oliver
Ventura, Maria Teresa
Regateiro, Frederico S.
Bindslev-Jensen, Carsten
Ring, Johannes
Bustamante, Mariona
Pinto, Bernardo Sousa
Kaidashev, Igor
Guerra, Stefano
Standl, Marie
Sunyer, J.
Keil, Thomas
Barata, Luís Taborda
Camargos, Paulo
Weiss, Scott
Naclerio, Robert
Yorgancıoglu, Arzu
Zhang, Luo
Nadeau, Kari
Abdul Latiff, Amir
Aberer, Werner
Heinrich, Joachim
Sisul, Juan
Nunes, Elizabete
Plavec, Davor
Agache, Ioana
Al-Ahmad, Mona
Serpa, Faradiba
Alobid, Isam
Kalayci, Omer
Giacco, S. Del
Fiocchi, Alessandro
Ansotegui Zubeldia, Ignacio Javier
Custovic, Adnan
Martins, Pedro Carreiro
Rouadi, Philip
Arshad, Syed Hasan
Asayag, Estrella
Bárbara, Cristina
Abdullah, Baharudin
Tomazic, Peter Valentin
Popov, T. A.
Sayah, Zineb
Lkhagvaa, Battur
Nyembue Tshipukane , Dieudonne
Thomas, Mike
Bennoor, Kazi Saifuddin
Fyhrquist, Nanna Theresia
Irani, Carla
Berghea, Elena Camelia
De Blay, Frédéric
Toppila-Salmi, Sanna Katriina
Bergmann, Karl-Christian
Bernstein, D.
Bewick, M.
Casale, Thomas
Scheire, Sophie
Bumbacea, Roxana Silvia
Cepeda Sarabia, Alfonso
Puggioni, Francesca
Chandrasekharan, Ramanathan
Ohta, Ken
Okubo, Kimihiro
Charpin, Denis
Gomez, R Maximiliano
Chen, Y. Z.
O'Hehir, Robyn
Cherrez Ojeda, Ivan
Bedbrook, Anna
To, Teresa
Devillier, Philippe
Schmid-Grendelmeier, Peter
Didier, Alain
Repka-Ramirez, María Susana
Teixeira, Maria Do Céu
Ispayeva, Zhanat
Dokic, Dejan
Quirce, Santiago
Douagui , Habib
Ivancevich, Juan Carlos
Gotua, Maia
Todo-Bom, Ana
Blain, Hubert
Guzman, Maria Antonieta
Kalyoncu, Ali Fuat
Hagemann, Jan
Buhl, Roland
Hamamah, Samir
Caraballo, Luis
Jares, Edgardo
Chivato, Tomás
Jartti, Tuomas
Jassem, Ewa
Christoff, George
Julge, Kalev
Ogulur, Ismail
Kardas, Przemyslaw
Doulaptsi, Maria
Kirenga, Bruce
Helga, Kraxner
Kull, Inger
Kulus, Marek
Daniel, Aguilar
Shamji, Mohamed
Kuna, Piotr
Nadif, Rachel
La Grutta, Stefania
Brightling, Chris
Samoliński, Bolesław
Lau, Susanne
Cordeiro, Carlos Manuel Da Silva Robalo
Solé, Dirceu
Le Thi Tuyet, Lan
Recto, Marysia
Ouedraogo, Solange
Halken, Susanne
Levin, Michael
Lipworth, Brian
Lourenço, Olga
Mahboub, Bassam
Niedoszytko, Marek
Sastre, Joaquin
Martinez‐Infante, E.
Kupczyk, Maciej
Torres, María Jose
Matricardi, Paolo Maria
Cecchi, Lorenzo
Celedón, Juan C
Miculinic, Neven
Roche, Nicolas
Migueres, Nicolas
Brussino, Luisa
Florin, Mihaltan
Olze, Heidi
Savouré, Marine
Nekam, Kristof
Pali, Isabella
Okamoto, Yoshitaka
Palomares, O.
Lemonnier, Nathanaël
Palosuo, Kati
Soto-Martinez, Manuel
Panaitescu, Carmen
Kvedarienė, Violeta
Panzner, P.
Braido, Fulvio
Tsiligianni, Ioanna
Rodriguez-Gonzalez, Monica
Scichilone, Nicola
Canonica, Giogio Walter
Romantowski, Jan
Urrutia-Pereira, Marilyn
Filho, Nelson Augusto Rosario
Ollert, Markus W.
Rottem, Menachem
Chkhartishvili, Ekaterine
Sova, Milan
Valovirta, Erkka
Mohammad, Yousser
Sperl, Annette
Spranger, Otto
Neffen, Hugo
Stelmach, Rafael
Burte, Emilie
Valentin Rostan, Marylin
Park, Hae-Sim
Van Ganse, Eric
Van Hage, Marianne
Pitsios, Constantinos
Vasankari, Tuula
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dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Bousquet, Jean
Melén, Erik
Haahtela, Tari
Koppelman, Gerard
Togias, Alkis
Valenta, Rudolf
Akdis, Cezmi
Czarlewski, Wienczyslawa
Rothenberg, Marc
Valiulis, Arunas
Wickman, Magnus
Vichyanond, Pakit
Moniuszko, Marcin
Ėmužytė, Regina
Bush, Andrew
Chu, Derek K
Viegi, Giovanni
Wallace, Dana
Durham, Stephen
Wang, De Yun
Vandenplas, O.
Just, Jocelyne
Carlsen, Karin C. Lodrup
Passalacqua, Giovanni
Williams, Siân
Linnemann, Désirée Larenas
Loureiro, Cláudia Chaves
Sagara, Hironori
Worm, Margitta
Yiallouros, Panayiotis
Yusuf, Osman
Zaitoun, Fares
Bonini, Matteo
Hrubiško, Martin
Cingi, C.
Dykewicz, Mark
Zernotti, Mario
Calderon, Moises
Halpin, David M.G.
Zidarn, Mihaela
Patella, Vincenzo
Sheikh, Aziz
Zuberbier, Jaron
Papadopoulos, Nikolaos
Louis, Renaud
Suppli Ulrik, Charlotte
Fonseca, João P.
Zuberbier, Torsten
Anto, M. J.
Costa, Elisio
Eiwegger, Thomas
Bosnic-Anticevich, Sinthia
Cruz, Alvaro
Sousa, Jaime Correia de
Louis-Philippe, Boulet
Erhola, Marina
Cardona, Victoria
Carr, Warner
Gemicioglu, Bilun
Pawankar, Ruby
Fokkens, Wytske
Calvo, Mário
Garcia-Aymerich, J.
Mäkelä, Mika J.
Hofmann, Maja Ann
Klimek, Ludger
Makris, Michael
Mohamed Sayed, Zeinab
Maurer, Marcus
D'Amato, G.
Momas, Isabelle
Siroux, Valérie
Almeida, Mário Morais
Corrigan, Chris
Mullol, Joaquim
Montefort, Stephen
Jutel, Marek
Pham Thi, Nhan
Hossny, Elham
Akdis, Mubeccel
Pfaar, Oliver
Ventura, Maria Teresa
Regateiro, Frederico S.
Bindslev-Jensen, Carsten
Ring, Johannes
Bustamante, Mariona
Pinto, Bernardo Sousa
Kaidashev, Igor
Guerra, Stefano
Standl, Marie
Sunyer, J.
Keil, Thomas
Barata, Luís Taborda
Camargos, Paulo
Weiss, Scott
Naclerio, Robert
Yorgancıoglu, Arzu
Zhang, Luo
Nadeau, Kari
Abdul Latiff, Amir
Aberer, Werner
Heinrich, Joachim
Sisul, Juan
Nunes, Elizabete
Plavec, Davor
Agache, Ioana
Al-Ahmad, Mona
Serpa, Faradiba
Alobid, Isam
Kalayci, Omer
Giacco, S. Del
Fiocchi, Alessandro
Ansotegui Zubeldia, Ignacio Javier
Custovic, Adnan
Martins, Pedro Carreiro
Rouadi, Philip
Arshad, Syed Hasan
Asayag, Estrella
Bárbara, Cristina
Abdullah, Baharudin
Tomazic, Peter Valentin
Popov, T. A.
Sayah, Zineb
Lkhagvaa, Battur
Nyembue Tshipukane , Dieudonne
Thomas, Mike
Bennoor, Kazi Saifuddin
Fyhrquist, Nanna Theresia
Irani, Carla
Berghea, Elena Camelia
De Blay, Frédéric
Toppila-Salmi, Sanna Katriina
Bergmann, Karl-Christian
Bernstein, D.
Bewick, M.
Casale, Thomas
Scheire, Sophie
Bumbacea, Roxana Silvia
Cepeda Sarabia, Alfonso
Puggioni, Francesca
Chandrasekharan, Ramanathan
Ohta, Ken
Okubo, Kimihiro
Charpin, Denis
Gomez, R Maximiliano
Chen, Y. Z.
O'Hehir, Robyn
Cherrez Ojeda, Ivan
Bedbrook, Anna
To, Teresa
Devillier, Philippe
Schmid-Grendelmeier, Peter
Didier, Alain
Repka-Ramirez, María Susana
Teixeira, Maria Do Céu
Ispayeva, Zhanat
Dokic, Dejan
Quirce, Santiago
Douagui , Habib
Ivancevich, Juan Carlos
Gotua, Maia
Todo-Bom, Ana
Blain, Hubert
Guzman, Maria Antonieta
Kalyoncu, Ali Fuat
Hagemann, Jan
Buhl, Roland
Hamamah, Samir
Caraballo, Luis
Jares, Edgardo
Chivato, Tomás
Jartti, Tuomas
Jassem, Ewa
Christoff, George
Julge, Kalev
Ogulur, Ismail
Kardas, Przemyslaw
Doulaptsi, Maria
Kirenga, Bruce
Helga, Kraxner
Kull, Inger
Kulus, Marek
Daniel, Aguilar
Shamji, Mohamed
Kuna, Piotr
Nadif, Rachel
La Grutta, Stefania
Brightling, Chris
Samoliński, Bolesław
Lau, Susanne
Cordeiro, Carlos Manuel Da Silva Robalo
Solé, Dirceu
Le Thi Tuyet, Lan
Recto, Marysia
Ouedraogo, Solange
Halken, Susanne
Levin, Michael
Lipworth, Brian
Lourenço, Olga
Mahboub, Bassam
Niedoszytko, Marek
Sastre, Joaquin
Martinez‐Infante, E.
Kupczyk, Maciej
Torres, María Jose
Matricardi, Paolo Maria
Cecchi, Lorenzo
Celedón, Juan C
Miculinic, Neven
Roche, Nicolas
Migueres, Nicolas
Brussino, Luisa
Florin, Mihaltan
Olze, Heidi
Savouré, Marine
Nekam, Kristof
Pali, Isabella
Okamoto, Yoshitaka
Palomares, O.
Lemonnier, Nathanaël
Palosuo, Kati
Soto-Martinez, Manuel
Panaitescu, Carmen
Kvedarienė, Violeta
Panzner, P.
Braido, Fulvio
Tsiligianni, Ioanna
Rodriguez-Gonzalez, Monica
Scichilone, Nicola
Canonica, Giogio Walter
Romantowski, Jan
Urrutia-Pereira, Marilyn
Filho, Nelson Augusto Rosario
Ollert, Markus W.
Rottem, Menachem
Chkhartishvili, Ekaterine
Sova, Milan
Valovirta, Erkka
Mohammad, Yousser
Sperl, Annette
Spranger, Otto
Neffen, Hugo
Stelmach, Rafael
Burte, Emilie
Valentin Rostan, Marylin
Park, Hae-Sim
Van Ganse, Eric
Van Hage, Marianne
Pitsios, Constantinos
Vasankari, Tuula
dc.subject.por.fl_str_mv Asthma
Toll-like receptors
Multimorbidity
Rhinitis
IL-33
topic Asthma
Toll-like receptors
Multimorbidity
Rhinitis
IL-33
description Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-21T15:55:25Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/13302
url http://hdl.handle.net/10400.6/13302
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1111/all.15679
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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