The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.15/2911 |
Resumo: | Rationale The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives We investigated the effects of bexarotene (Bexa, a RXR agonist) or UVI 3003 (UVI, a RXR antagonist) on sleep, sleep homeostasis, levels of neurochemical related to sleep modulation, and c-Fos and NeuN expression. Methods The sleep-wake cycle and sleep homeostasis were analyzed after application of Bexa or UVI. Moreover, we also evaluated whether Bexa or UVI could induce effects on dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine contents, collected from either the nucleus accumbens or basal forebrain. In addition, c-Fos and NeuN expression in the hypothalamus was determined after Bexa or UVI treatments. Results Systemic application of Bexa (1 mM, i.p.) attenuated slow-wave sleep and rapid eye movement sleep. In addition, Bexa increased the levels of dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine sampled from either the nucleus accumbens or basal forebrain. Moreover, Bexa blocked the sleep rebound period after total sleep deprivation, increased in the hypothalamus the expression of c-Fos, and decreased NeuN activity. Remarkably, UVI 3003 (1 mM, i.p.) induced opposite effects in sleep, sleep homeostasis, neurochemicals levels, and c-Fos and NeuN activity. Conclusions The administration of RXR agonist or antagonist significantly impaired the sleep-wake cycle and exerted effects on the levels of neurochemicals related to sleep modulation. Moreover, Bexa or UVI administration significantly affected c-Fos and NeuN expression in the hypothalamus. Our findings highlight the neurobiological role of RXR on sleep modulation. |
id |
RCAP_8b28f21df381c6f6e295c3c62fd3ac3b |
---|---|
oai_identifier_str |
oai:repositorio.ipsantarem.pt:10400.15/2911 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in ratsAdenosineDopamineRetinoid X receptorSerotoninSleepRationale The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives We investigated the effects of bexarotene (Bexa, a RXR agonist) or UVI 3003 (UVI, a RXR antagonist) on sleep, sleep homeostasis, levels of neurochemical related to sleep modulation, and c-Fos and NeuN expression. Methods The sleep-wake cycle and sleep homeostasis were analyzed after application of Bexa or UVI. Moreover, we also evaluated whether Bexa or UVI could induce effects on dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine contents, collected from either the nucleus accumbens or basal forebrain. In addition, c-Fos and NeuN expression in the hypothalamus was determined after Bexa or UVI treatments. Results Systemic application of Bexa (1 mM, i.p.) attenuated slow-wave sleep and rapid eye movement sleep. In addition, Bexa increased the levels of dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine sampled from either the nucleus accumbens or basal forebrain. Moreover, Bexa blocked the sleep rebound period after total sleep deprivation, increased in the hypothalamus the expression of c-Fos, and decreased NeuN activity. Remarkably, UVI 3003 (1 mM, i.p.) induced opposite effects in sleep, sleep homeostasis, neurochemicals levels, and c-Fos and NeuN activity. Conclusions The administration of RXR agonist or antagonist significantly impaired the sleep-wake cycle and exerted effects on the levels of neurochemicals related to sleep modulation. Moreover, Bexa or UVI administration significantly affected c-Fos and NeuN expression in the hypothalamus. Our findings highlight the neurobiological role of RXR on sleep modulation.Springer Nature [academic journals on nature.com]Repositório Científico do Instituto Politécnico de SantarémMurillo-Rodríguez, EricMillán-Aldaco, DianaArankowsky-Sandoval, GloriaYamamoto, TetsuyaCid, LuisMonteiro, DiogoRocha, Nuno BarbosaTelles-Correia, DiogoTeixeira, Diogo S.Veras, André BarcielaBudde, HenningMachado, SérgioImperatori, ClaudioTorterolo, Pablo2021-05-30T00:30:11Z2020-05-302020-05-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.15/2911engMurillo-Rodríguez, E., Millán-Aldaco, D., Arankowsky-Sandoval, G. et al. The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. Psychopharmacology (2020). https://doi.org/10.1007/s00213-020-05518-80033-315810.1007/s00213-020-05518-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:34:17Zoai:repositorio.ipsantarem.pt:10400.15/2911Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:54:47.590622Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
title |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
spellingShingle |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats Murillo-Rodríguez, Eric Adenosine Dopamine Retinoid X receptor Serotonin Sleep |
title_short |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
title_full |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
title_fullStr |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
title_full_unstemmed |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
title_sort |
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats |
author |
Murillo-Rodríguez, Eric |
author_facet |
Murillo-Rodríguez, Eric Millán-Aldaco, Diana Arankowsky-Sandoval, Gloria Yamamoto, Tetsuya Cid, Luis Monteiro, Diogo Rocha, Nuno Barbosa Telles-Correia, Diogo Teixeira, Diogo S. Veras, André Barciela Budde, Henning Machado, Sérgio Imperatori, Claudio Torterolo, Pablo |
author_role |
author |
author2 |
Millán-Aldaco, Diana Arankowsky-Sandoval, Gloria Yamamoto, Tetsuya Cid, Luis Monteiro, Diogo Rocha, Nuno Barbosa Telles-Correia, Diogo Teixeira, Diogo S. Veras, André Barciela Budde, Henning Machado, Sérgio Imperatori, Claudio Torterolo, Pablo |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Santarém |
dc.contributor.author.fl_str_mv |
Murillo-Rodríguez, Eric Millán-Aldaco, Diana Arankowsky-Sandoval, Gloria Yamamoto, Tetsuya Cid, Luis Monteiro, Diogo Rocha, Nuno Barbosa Telles-Correia, Diogo Teixeira, Diogo S. Veras, André Barciela Budde, Henning Machado, Sérgio Imperatori, Claudio Torterolo, Pablo |
dc.subject.por.fl_str_mv |
Adenosine Dopamine Retinoid X receptor Serotonin Sleep |
topic |
Adenosine Dopamine Retinoid X receptor Serotonin Sleep |
description |
Rationale The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives We investigated the effects of bexarotene (Bexa, a RXR agonist) or UVI 3003 (UVI, a RXR antagonist) on sleep, sleep homeostasis, levels of neurochemical related to sleep modulation, and c-Fos and NeuN expression. Methods The sleep-wake cycle and sleep homeostasis were analyzed after application of Bexa or UVI. Moreover, we also evaluated whether Bexa or UVI could induce effects on dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine contents, collected from either the nucleus accumbens or basal forebrain. In addition, c-Fos and NeuN expression in the hypothalamus was determined after Bexa or UVI treatments. Results Systemic application of Bexa (1 mM, i.p.) attenuated slow-wave sleep and rapid eye movement sleep. In addition, Bexa increased the levels of dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine sampled from either the nucleus accumbens or basal forebrain. Moreover, Bexa blocked the sleep rebound period after total sleep deprivation, increased in the hypothalamus the expression of c-Fos, and decreased NeuN activity. Remarkably, UVI 3003 (1 mM, i.p.) induced opposite effects in sleep, sleep homeostasis, neurochemicals levels, and c-Fos and NeuN activity. Conclusions The administration of RXR agonist or antagonist significantly impaired the sleep-wake cycle and exerted effects on the levels of neurochemicals related to sleep modulation. Moreover, Bexa or UVI administration significantly affected c-Fos and NeuN expression in the hypothalamus. Our findings highlight the neurobiological role of RXR on sleep modulation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-30 2020-05-30T00:00:00Z 2021-05-30T00:30:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.15/2911 |
url |
http://hdl.handle.net/10400.15/2911 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Murillo-Rodríguez, E., Millán-Aldaco, D., Arankowsky-Sandoval, G. et al. The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. Psychopharmacology (2020). https://doi.org/10.1007/s00213-020-05518-8 0033-3158 10.1007/s00213-020-05518-8 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature [academic journals on nature.com] |
publisher.none.fl_str_mv |
Springer Nature [academic journals on nature.com] |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137037767409664 |