Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158475 |
Resumo: | Funding Information: The authors acknowledge the Fundação para a Ciência e a Tecnologia, I.P., through (i) MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020), (ii) LS4FUTURE Associated Laboratory (LA/P/0087/2020), (iii) POPH (Programa Operacional Potencial Humano), and FSE (European Social Fund) CEEC 2017 Initiative (to O.A.L.-R.) and (iv) PhD fellowship to A.P. (SFRH/BD/148854/2019). D.P.-P was the recipient of a postdoctoral fellowship from the National Council of Science and Technology (CONACYT) of Mexico. Publisher Copyright: © 2023 by the authors. |
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Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.antifungalCandidamarine natural productsYucatan PeninsulaAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 14 - Life Below WaterFunding Information: The authors acknowledge the Fundação para a Ciência e a Tecnologia, I.P., through (i) MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020), (ii) LS4FUTURE Associated Laboratory (LA/P/0087/2020), (iii) POPH (Programa Operacional Potencial Humano), and FSE (European Social Fund) CEEC 2017 Initiative (to O.A.L.-R.) and (iv) PhD fellowship to A.P. (SFRH/BD/148854/2019). D.P.-P was the recipient of a postdoctoral fellowship from the National Council of Science and Technology (CONACYT) of Mexico. Publisher Copyright: © 2023 by the authors.Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNPech-Puch, DawrinGrilo, DianaCalva-Pérez, Susana EunicePedras, AndreiaVillegas-Hernández, HaroldGuillén-Hernández, SergioDíaz-Gamboa, RaúlTunjano, Mateo ForeroRodríguez, JaimeLenis-Rojas, Oscar A.Jiménez, CarlosPimentel, Catarina2023-09-29T22:21:33Z2023-012023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158475eng1420-3049PURE: 72096069https://doi.org/10.3390/molecules28020606info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:52Zoai:run.unl.pt:10362/158475Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:09.504003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| spellingShingle |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. Pech-Puch, Dawrin antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| title_short |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_full |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_fullStr |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_full_unstemmed |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_sort |
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| author |
Pech-Puch, Dawrin |
| author_facet |
Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| author_role |
author |
| author2 |
Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| dc.subject.por.fl_str_mv |
antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| topic |
antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| description |
Funding Information: The authors acknowledge the Fundação para a Ciência e a Tecnologia, I.P., through (i) MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020), (ii) LS4FUTURE Associated Laboratory (LA/P/0087/2020), (iii) POPH (Programa Operacional Potencial Humano), and FSE (European Social Fund) CEEC 2017 Initiative (to O.A.L.-R.) and (iv) PhD fellowship to A.P. (SFRH/BD/148854/2019). D.P.-P was the recipient of a postdoctoral fellowship from the National Council of Science and Technology (CONACYT) of Mexico. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-29T22:21:33Z 2023-01 2023-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158475 |
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http://hdl.handle.net/10362/158475 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1420-3049 PURE: 72096069 https://doi.org/10.3390/molecules28020606 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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