Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.11/8069 |
Resumo: | Abstract: Pancreatic cancer (PC) has an important role in the clinical and research area representing one of the lowest five-year rates as well as a global mortality rate of 4.8% due to its late and poor diagnosis. Therapeutic strategies have also an unsatisfactory response. Even after surgery, the recurrence or appearance of metastasis are frequent, leading to a poor overall survival. The PC has been related with several mutations, including K-RAS; P16; TP53; HER2. Besides, it is also associated with the deleted in pancreatic cancer locus 4 (DPC4), also known as the suppressor mothers against decapentaplegic homolog 4 (SMAD4) which is present in nearly 50% of the diagnosed patients with PC. Preceding studies proved that SMAD4 loss expression plays an important role in tumorigenesis and in the promotion of pancreatic carcinoma´s growth. Therefore, it is highly relevant in late stages suggesting that SMAD4 may be a molecular biomarker in prognostic results. The main goal of this review is to highlight the foregoing findings focused on SMAD4 deletion and its influence in clinicopathological parameters in pancreatic carcinoma by referring some of the investigations and clinical trials made in this field. Furthermore, it is also required to contemplate some of the therapeutical strategies and the influence of SMAD4 in future therapies |
id |
RCAP_8cfb8b210d6556979bf860f36d66c488 |
---|---|
oai_identifier_str |
oai:repositorio.ipcb.pt:10400.11/8069 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinomaPancreatic cancerSMAD4TGF-βAbstract: Pancreatic cancer (PC) has an important role in the clinical and research area representing one of the lowest five-year rates as well as a global mortality rate of 4.8% due to its late and poor diagnosis. Therapeutic strategies have also an unsatisfactory response. Even after surgery, the recurrence or appearance of metastasis are frequent, leading to a poor overall survival. The PC has been related with several mutations, including K-RAS; P16; TP53; HER2. Besides, it is also associated with the deleted in pancreatic cancer locus 4 (DPC4), also known as the suppressor mothers against decapentaplegic homolog 4 (SMAD4) which is present in nearly 50% of the diagnosed patients with PC. Preceding studies proved that SMAD4 loss expression plays an important role in tumorigenesis and in the promotion of pancreatic carcinoma´s growth. Therefore, it is highly relevant in late stages suggesting that SMAD4 may be a molecular biomarker in prognostic results. The main goal of this review is to highlight the foregoing findings focused on SMAD4 deletion and its influence in clinicopathological parameters in pancreatic carcinoma by referring some of the investigations and clinical trials made in this field. Furthermore, it is also required to contemplate some of the therapeutical strategies and the influence of SMAD4 in future therapiesIPCB. ESALDRepositório Científico do Instituto Politécnico de Castelo BrancoVareda, C.Teixeira, P.F.Martins, D.R.Valado, A.M.Mendes, F. J.2022-08-02T12:55:23Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.11/8069engVAREDA, C. [et al.] (2021) - Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma. HIGEIA: Revista Científica da Escola Superior de Saúde Dr. Lopes Dias. ISSN 2184-5565. Ano III, vol. 6, n.º 2, p.65-71.2184-5565info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T11:49:22Zoai:repositorio.ipcb.pt:10400.11/8069Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:38:31.413002Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
title |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
spellingShingle |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma Vareda, C. Pancreatic cancer SMAD4 TGF-β |
title_short |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
title_full |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
title_fullStr |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
title_full_unstemmed |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
title_sort |
Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma |
author |
Vareda, C. |
author_facet |
Vareda, C. Teixeira, P.F. Martins, D.R. Valado, A.M. Mendes, F. J. |
author_role |
author |
author2 |
Teixeira, P.F. Martins, D.R. Valado, A.M. Mendes, F. J. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Castelo Branco |
dc.contributor.author.fl_str_mv |
Vareda, C. Teixeira, P.F. Martins, D.R. Valado, A.M. Mendes, F. J. |
dc.subject.por.fl_str_mv |
Pancreatic cancer SMAD4 TGF-β |
topic |
Pancreatic cancer SMAD4 TGF-β |
description |
Abstract: Pancreatic cancer (PC) has an important role in the clinical and research area representing one of the lowest five-year rates as well as a global mortality rate of 4.8% due to its late and poor diagnosis. Therapeutic strategies have also an unsatisfactory response. Even after surgery, the recurrence or appearance of metastasis are frequent, leading to a poor overall survival. The PC has been related with several mutations, including K-RAS; P16; TP53; HER2. Besides, it is also associated with the deleted in pancreatic cancer locus 4 (DPC4), also known as the suppressor mothers against decapentaplegic homolog 4 (SMAD4) which is present in nearly 50% of the diagnosed patients with PC. Preceding studies proved that SMAD4 loss expression plays an important role in tumorigenesis and in the promotion of pancreatic carcinoma´s growth. Therefore, it is highly relevant in late stages suggesting that SMAD4 may be a molecular biomarker in prognostic results. The main goal of this review is to highlight the foregoing findings focused on SMAD4 deletion and its influence in clinicopathological parameters in pancreatic carcinoma by referring some of the investigations and clinical trials made in this field. Furthermore, it is also required to contemplate some of the therapeutical strategies and the influence of SMAD4 in future therapies |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-08-02T12:55:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.11/8069 |
url |
http://hdl.handle.net/10400.11/8069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
VAREDA, C. [et al.] (2021) - Loss of mothers against decapentaplegic homolog 4 (SMAD4) expression and its correlation with clinicopathological parameters in pancreatic carcinoma. HIGEIA: Revista Científica da Escola Superior de Saúde Dr. Lopes Dias. ISSN 2184-5565. Ano III, vol. 6, n.º 2, p.65-71. 2184-5565 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IPCB. ESALD |
publisher.none.fl_str_mv |
IPCB. ESALD |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130849442004992 |