Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Sousa, K
Data de Publicação: 2018
Outros Autores: Fernandes, T, Gentil, R, Mendonça, L, Falcão, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/1292
Resumo: PURPOSE: To evaluate the integrity of the outer retinal layers-outer nuclear layer (ONL), external limiting membrane (ELM), ellipsoid (EZ), and interdigitation band (IZ)-using spectral-domain optical coherence tomography and estimate their effect on visual acuity in retinitis pigmentosa (RP). METHODS: A cross-sectional study was performed in the Ophthalmology Department of Hospital de Braga, Portugal. Patients with RP followed in the Hospital de Braga during January to August 2017 were included. Exclusion criteria were lack of data, macular edema due to RP, and concomitant retinal, optic nerve, or corneal disease that could interfere with visual acuity. Age, sex, time from diagnosis, phakic status, ONL thickness, and presence or absence of foveal ELM, EZ, and IZ were correlated to the best-corrected visual acuity (BCVA). RESULTS: Forty-eight eyes were analyzed. There was a strong and positive correlation in BCVA between both eyes (p < .001*). ONL thickness was decreased in 95.8%. The EZ was the most absent layer (79.2%), followed by IZ (70.8%) and ELM (45.8%). A positive family history (p = .04*) and increased time from diagnosis (p = .037*) correlated with worse BCVA. A thicker ONL (p = .001*) and the presence of subfoveal ELM (p < .001*), EZ (p < .001*), and IZ (p = .02*) are correlated with better BCVA. There was a strong and positive correlation between the number of layers affected and a lower BCVA (p < .001). The presence of EZ was a significant predictor of BCVA (p = .02*). CONCLUSIONS: The status of the outer retinal layers seems to influence BCVA. The status of the EZ was the most important predictor of BCVA but the ONL, ELM, and IZ may have a cumulative effect in the progression of visual loss.
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spelling Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional studyRetinite PigmentosaTomografia de Coerência ÓpticaPURPOSE: To evaluate the integrity of the outer retinal layers-outer nuclear layer (ONL), external limiting membrane (ELM), ellipsoid (EZ), and interdigitation band (IZ)-using spectral-domain optical coherence tomography and estimate their effect on visual acuity in retinitis pigmentosa (RP). METHODS: A cross-sectional study was performed in the Ophthalmology Department of Hospital de Braga, Portugal. Patients with RP followed in the Hospital de Braga during January to August 2017 were included. Exclusion criteria were lack of data, macular edema due to RP, and concomitant retinal, optic nerve, or corneal disease that could interfere with visual acuity. Age, sex, time from diagnosis, phakic status, ONL thickness, and presence or absence of foveal ELM, EZ, and IZ were correlated to the best-corrected visual acuity (BCVA). RESULTS: Forty-eight eyes were analyzed. There was a strong and positive correlation in BCVA between both eyes (p < .001*). ONL thickness was decreased in 95.8%. The EZ was the most absent layer (79.2%), followed by IZ (70.8%) and ELM (45.8%). A positive family history (p = .04*) and increased time from diagnosis (p = .037*) correlated with worse BCVA. A thicker ONL (p = .001*) and the presence of subfoveal ELM (p < .001*), EZ (p < .001*), and IZ (p = .02*) are correlated with better BCVA. There was a strong and positive correlation between the number of layers affected and a lower BCVA (p < .001). The presence of EZ was a significant predictor of BCVA (p = .02*). CONCLUSIONS: The status of the outer retinal layers seems to influence BCVA. The status of the EZ was the most important predictor of BCVA but the ONL, ELM, and IZ may have a cumulative effect in the progression of visual loss.Repositório Científico do Hospital de BragaSousa, KFernandes, TGentil, RMendonça, LFalcão, M2018-12-14T14:23:09Z2018-11-19T00:00:00Z2018-11-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1292engGraefes Arch Clin Exp Ophthalmol. 2018 Nov 19. doi: 10.1007/s00417-018-4185-410.1007/s00417-018-4185-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:03:12Zoai:repositorio.hospitaldebraga.pt:10400.23/1292Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:49.660906Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
title Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
spellingShingle Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
Sousa, K
Retinite Pigmentosa
Tomografia de Coerência Óptica
title_short Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
title_full Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
title_fullStr Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
title_full_unstemmed Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
title_sort Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study
author Sousa, K
author_facet Sousa, K
Fernandes, T
Gentil, R
Mendonça, L
Falcão, M
author_role author
author2 Fernandes, T
Gentil, R
Mendonça, L
Falcão, M
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Sousa, K
Fernandes, T
Gentil, R
Mendonça, L
Falcão, M
dc.subject.por.fl_str_mv Retinite Pigmentosa
Tomografia de Coerência Óptica
topic Retinite Pigmentosa
Tomografia de Coerência Óptica
description PURPOSE: To evaluate the integrity of the outer retinal layers-outer nuclear layer (ONL), external limiting membrane (ELM), ellipsoid (EZ), and interdigitation band (IZ)-using spectral-domain optical coherence tomography and estimate their effect on visual acuity in retinitis pigmentosa (RP). METHODS: A cross-sectional study was performed in the Ophthalmology Department of Hospital de Braga, Portugal. Patients with RP followed in the Hospital de Braga during January to August 2017 were included. Exclusion criteria were lack of data, macular edema due to RP, and concomitant retinal, optic nerve, or corneal disease that could interfere with visual acuity. Age, sex, time from diagnosis, phakic status, ONL thickness, and presence or absence of foveal ELM, EZ, and IZ were correlated to the best-corrected visual acuity (BCVA). RESULTS: Forty-eight eyes were analyzed. There was a strong and positive correlation in BCVA between both eyes (p < .001*). ONL thickness was decreased in 95.8%. The EZ was the most absent layer (79.2%), followed by IZ (70.8%) and ELM (45.8%). A positive family history (p = .04*) and increased time from diagnosis (p = .037*) correlated with worse BCVA. A thicker ONL (p = .001*) and the presence of subfoveal ELM (p < .001*), EZ (p < .001*), and IZ (p = .02*) are correlated with better BCVA. There was a strong and positive correlation between the number of layers affected and a lower BCVA (p < .001). The presence of EZ was a significant predictor of BCVA (p = .02*). CONCLUSIONS: The status of the outer retinal layers seems to influence BCVA. The status of the EZ was the most important predictor of BCVA but the ONL, ELM, and IZ may have a cumulative effect in the progression of visual loss.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-14T14:23:09Z
2018-11-19T00:00:00Z
2018-11-19T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url http://hdl.handle.net/10400.23/1292
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Graefes Arch Clin Exp Ophthalmol. 2018 Nov 19. doi: 10.1007/s00417-018-4185-4
10.1007/s00417-018-4185-4
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