Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.

Detalhes bibliográficos
Autor(a) principal: Barbosa, R. R.
Data de Publicação: 2011
Outros Autores: Silva, S. P., Silva, S. L., Melo, A. C., Pedro, E., Barbosa, M. P., Pereira-Santos, M. C., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18307
Resumo: © 2011 Barbosa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.© 2011 Barbosa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation and the circulating follicular T helper subset was recently shown to be enriched in Th17 cells able to help B-cell differentiation. We investigated a putative link between Th17-cell homeostasis and B cells by studying the Th17-cell compartment in primary B-cell immunodeficiencies. Common Variable Immunodeficiency Disorders (CVID), defined by defects in B-cell differentiation into plasma and memory B cells, are frequently associated with autoimmune and inflammatory manifestations but we found no relationship between these and Th17-cell frequency. In fact, CVID patients showed a decrease in Th17-cell frequency in parallel with the expansion of activated non-differentiated B cells (CD21(low)CD38(low)). Moreover, Congenital Agammaglobulinemia patients, lacking B cells due to impaired early B-cell development, had a severe reduction of circulating Th17 cells. Finally, we found a direct correlation in healthy individuals between circulating Th17-cell frequency and both switched-memory B cells and serum BAFF levels, a crucial cytokine for B-cell survival. Overall, our data support a relationship between Th17-cell homeostasis and B-cell maturation, with implications for the understanding of the pathogenesis of inflammatory/autoimmune diseases and the physiology of B-cell depleting therapies.This work was supported by grants from ‘‘Fundação para a Ciência e a Tecnologia’’ (FCT) and by ‘‘Programa Operacional Ciência e Inovação 2010’’ (POCI2010) (R.M.M.V. and A.E.S.). R.R.B. received a PhD scholarship from FCT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of ScienceRepositório da Universidade de LisboaBarbosa, R. R.Silva, S. P.Silva, S. L.Melo, A. C.Pedro, E.Barbosa, M. P.Pereira-Santos, M. C.Victorino, R. M.Sousa, A. E.2015-06-17T14:10:18Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18307engPLoS ONE August 2011 | Volume 6 | Issue 8 | e228481932-6203http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022848info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-14T15:11:02ZPortal AgregadorONG
dc.title.none.fl_str_mv Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
title Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
spellingShingle Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
Barbosa, R. R.
title_short Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
title_full Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
title_fullStr Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
title_full_unstemmed Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
title_sort Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
author Barbosa, R. R.
author_facet Barbosa, R. R.
Silva, S. P.
Silva, S. L.
Melo, A. C.
Pedro, E.
Barbosa, M. P.
Pereira-Santos, M. C.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Silva, S. P.
Silva, S. L.
Melo, A. C.
Pedro, E.
Barbosa, M. P.
Pereira-Santos, M. C.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barbosa, R. R.
Silva, S. P.
Silva, S. L.
Melo, A. C.
Pedro, E.
Barbosa, M. P.
Pereira-Santos, M. C.
Victorino, R. M.
Sousa, A. E.
description © 2011 Barbosa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2015-06-17T14:10:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18307
url http://hdl.handle.net/10451/18307
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE August 2011 | Volume 6 | Issue 8 | e22848
1932-6203
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022848
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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