Factors Associated With Asthma Control in 121 Preschool Children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4490 |
Resumo: | Background and objectives: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for uncontrolled asthma, as defined by the Global INitiative for Asthma criteria. Lung function and bronchial reversibility were evaluated through impulse oscillometry and spirometry. Adjusted odds ratios were estimated based on multivariable generalized additive regression models. The discriminative ability of the models was measured by the area under the receiver operating characteristic curve (AUC). Results: The study population comprised 121 children (107 with asthma and 14 healthy controls). Fifty-three patients (50%) had uncontrolled asthma. After adjustment, the variables associated with an increased risk of lack of control were as follows: "More than 3 flare-ups in the last 12 months", "Moderate to severe rhinitis", and "Relative variation in postbronchodilator FVC and FEV1". The AUC of the final models that included variation in FVC or FEV1 were 0.82 and 0.81, respectively. The R5-20, R5-20%, and AX z-score values of the healthy group were lower than those of children with asthma. Conclusion: In preschool children, clinical and functional parameters are associated with uncontrolled asthma. More studies are needed to confirm the usefulness of impulse oscillometry. |
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Factors Associated With Asthma Control in 121 Preschool ChildrenAsthma* / diagnosisAsthma* / epidemiologyChild, PreschoolForced Expiratory VolumeOdds RatioOscillometryRespiratory Function TestsSpirometryHDE ALERHDE CINVBackground and objectives: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for uncontrolled asthma, as defined by the Global INitiative for Asthma criteria. Lung function and bronchial reversibility were evaluated through impulse oscillometry and spirometry. Adjusted odds ratios were estimated based on multivariable generalized additive regression models. The discriminative ability of the models was measured by the area under the receiver operating characteristic curve (AUC). Results: The study population comprised 121 children (107 with asthma and 14 healthy controls). Fifty-three patients (50%) had uncontrolled asthma. After adjustment, the variables associated with an increased risk of lack of control were as follows: "More than 3 flare-ups in the last 12 months", "Moderate to severe rhinitis", and "Relative variation in postbronchodilator FVC and FEV1". The AUC of the final models that included variation in FVC or FEV1 were 0.82 and 0.81, respectively. The R5-20, R5-20%, and AX z-score values of the healthy group were lower than those of children with asthma. Conclusion: In preschool children, clinical and functional parameters are associated with uncontrolled asthma. More studies are needed to confirm the usefulness of impulse oscillometry.Esmon PublicidadRepositório do Centro Hospitalar Universitário de Lisboa Central, EPELeiria-Pinto, PCarreiro-Martins, PPeralta, IMarques, JFinelli, EAlves, CBelo, JAlves, MPapoila, ALNeuparth, N2023-04-13T14:11:01Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4490spaJ Investig Allergol Clin Immunol . 2021 Dec 21;31(6):471-48010.18176/jiaci.0630info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-16T05:45:34Zoai:repositorio.chlc.min-saude.pt:10400.17/4490Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:49:36.765208Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Factors Associated With Asthma Control in 121 Preschool Children |
title |
Factors Associated With Asthma Control in 121 Preschool Children |
spellingShingle |
Factors Associated With Asthma Control in 121 Preschool Children Leiria-Pinto, P Asthma* / diagnosis Asthma* / epidemiology Child, Preschool Forced Expiratory Volume Odds Ratio Oscillometry Respiratory Function Tests Spirometry HDE ALER HDE CINV |
title_short |
Factors Associated With Asthma Control in 121 Preschool Children |
title_full |
Factors Associated With Asthma Control in 121 Preschool Children |
title_fullStr |
Factors Associated With Asthma Control in 121 Preschool Children |
title_full_unstemmed |
Factors Associated With Asthma Control in 121 Preschool Children |
title_sort |
Factors Associated With Asthma Control in 121 Preschool Children |
author |
Leiria-Pinto, P |
author_facet |
Leiria-Pinto, P Carreiro-Martins, P Peralta, I Marques, J Finelli, E Alves, C Belo, J Alves, M Papoila, AL Neuparth, N |
author_role |
author |
author2 |
Carreiro-Martins, P Peralta, I Marques, J Finelli, E Alves, C Belo, J Alves, M Papoila, AL Neuparth, N |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Leiria-Pinto, P Carreiro-Martins, P Peralta, I Marques, J Finelli, E Alves, C Belo, J Alves, M Papoila, AL Neuparth, N |
dc.subject.por.fl_str_mv |
Asthma* / diagnosis Asthma* / epidemiology Child, Preschool Forced Expiratory Volume Odds Ratio Oscillometry Respiratory Function Tests Spirometry HDE ALER HDE CINV |
topic |
Asthma* / diagnosis Asthma* / epidemiology Child, Preschool Forced Expiratory Volume Odds Ratio Oscillometry Respiratory Function Tests Spirometry HDE ALER HDE CINV |
description |
Background and objectives: Data on risk factors for uncontrolled asthma in preschool children are controversial. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children aged 3-5 years with asthma and healthy controls were recruited. A questionnaire was used to identify potential risk factors for uncontrolled asthma, as defined by the Global INitiative for Asthma criteria. Lung function and bronchial reversibility were evaluated through impulse oscillometry and spirometry. Adjusted odds ratios were estimated based on multivariable generalized additive regression models. The discriminative ability of the models was measured by the area under the receiver operating characteristic curve (AUC). Results: The study population comprised 121 children (107 with asthma and 14 healthy controls). Fifty-three patients (50%) had uncontrolled asthma. After adjustment, the variables associated with an increased risk of lack of control were as follows: "More than 3 flare-ups in the last 12 months", "Moderate to severe rhinitis", and "Relative variation in postbronchodilator FVC and FEV1". The AUC of the final models that included variation in FVC or FEV1 were 0.82 and 0.81, respectively. The R5-20, R5-20%, and AX z-score values of the healthy group were lower than those of children with asthma. Conclusion: In preschool children, clinical and functional parameters are associated with uncontrolled asthma. More studies are needed to confirm the usefulness of impulse oscillometry. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-04-13T14:11:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4490 |
url |
http://hdl.handle.net/10400.17/4490 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
J Investig Allergol Clin Immunol . 2021 Dec 21;31(6):471-480 10.18176/jiaci.0630 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Esmon Publicidad |
publisher.none.fl_str_mv |
Esmon Publicidad |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131577214566400 |