Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/127790 |
Resumo: | Funding Information: We thank all the study participants, who donated blood and authorized the genetic analysis and the collection of the clinical and phenotypic personal data. This project was supported by the “Fundação para a Ciência e Tecnologia”, program “Research 4 Covid-19 Apoio especial a projetos de implementação rápida para soluções inovadoras de resposta à pandemia de COVID-19”. It was also partially supported by each institution. Publisher Copyright: © 2021, The Author(s). |
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Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severityGeneralFunding Information: We thank all the study participants, who donated blood and authorized the genetic analysis and the collection of the clinical and phenotypic personal data. This project was supported by the “Fundação para a Ciência e Tecnologia”, program “Research 4 Covid-19 Apoio especial a projetos de implementação rápida para soluções inovadoras de resposta à pandemia de COVID-19”. It was also partially supported by each institution. Publisher Copyright: © 2021, The Author(s).Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese population was characterized regarding the prevalence of high impact variants in genes associated with the vitamin D pathways. This study enrolled 517 patients admitted to two tertiary Portuguese hospitals. The serum concentration of 25 (OH)D, was measured in the hospital at the time of patient admission. Genetic variants, 18 variants, in the genes AMDHD1, CYP2R1, CYP24A1, DHCR7, GC, SEC23A, and VDR were analysed. The results show that polymorphisms in the vitamin D binding protein encoded by the GC gene are related to the infection severity (p = 0.005). There is an association between vitamin D polygenic risk score and the serum concentration of 25 (OH)D (p = 0.04). There is an association between 25 (OH)D levels and the survival and fatal outcomes (p = 1.5e−4). The Portuguese population has a higher prevalence of the DHCR7 RS12785878 variant when compared with its prevalence in the European population (19% versus 10%). This study shows a genetic susceptibility for vitamin D deficiency that might explain higher severity degrees in COVID-19 patients. These results reinforce the relevance of personalized strategies in the context of viral diseases. Trial registration: NCT04370808.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFreitas, Ana TeresaCalhau, ConceiçãoAntunes, GonçaloAraújo, BeatrizBandeira, MatildeBarreira, SofiaBazenga, FilipaBraz, SandraCaldeira, DanielSantos, Susana Constantino RosaFaria, AnaFaria, DanielFraga, MartaNogueira-Garcia, BeatrizGonçalves, LúciaKovalchuk, PavloLacerda, LuísaLopes, HugoLuís, DanielMedeiros, FábioMelo, Ana M.P.Melo-Cristino, JoséMiranda, AnaPereira, ClaraPinto, Ana TeresaPinto, JoãoProença, HelenaRamos, AngélicaRato, João P.R.Rocha, FilipeRocha, Júlio CésarMoreira-Rosário, AndréVazão, HelenaVolovetska, YuliyaGuimarães, João TiagoPinto, Fausto J.2021-11-15T23:36:39Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/127790eng2045-2322PURE: 34617811https://doi.org/10.1038/s41598-021-99952-zinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:07:38Zoai:run.unl.pt:10362/127790Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:12.580558Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| title |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| spellingShingle |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity Freitas, Ana Teresa General |
| title_short |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| title_full |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| title_fullStr |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| title_full_unstemmed |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| title_sort |
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity |
| author |
Freitas, Ana Teresa |
| author_facet |
Freitas, Ana Teresa Calhau, Conceição Antunes, Gonçalo Araújo, Beatriz Bandeira, Matilde Barreira, Sofia Bazenga, Filipa Braz, Sandra Caldeira, Daniel Santos, Susana Constantino Rosa Faria, Ana Faria, Daniel Fraga, Marta Nogueira-Garcia, Beatriz Gonçalves, Lúcia Kovalchuk, Pavlo Lacerda, Luísa Lopes, Hugo Luís, Daniel Medeiros, Fábio Melo, Ana M.P. Melo-Cristino, José Miranda, Ana Pereira, Clara Pinto, Ana Teresa Pinto, João Proença, Helena Ramos, Angélica Rato, João P.R. Rocha, Filipe Rocha, Júlio César Moreira-Rosário, André Vazão, Helena Volovetska, Yuliya Guimarães, João Tiago Pinto, Fausto J. |
| author_role |
author |
| author2 |
Calhau, Conceição Antunes, Gonçalo Araújo, Beatriz Bandeira, Matilde Barreira, Sofia Bazenga, Filipa Braz, Sandra Caldeira, Daniel Santos, Susana Constantino Rosa Faria, Ana Faria, Daniel Fraga, Marta Nogueira-Garcia, Beatriz Gonçalves, Lúcia Kovalchuk, Pavlo Lacerda, Luísa Lopes, Hugo Luís, Daniel Medeiros, Fábio Melo, Ana M.P. Melo-Cristino, José Miranda, Ana Pereira, Clara Pinto, Ana Teresa Pinto, João Proença, Helena Ramos, Angélica Rato, João P.R. Rocha, Filipe Rocha, Júlio César Moreira-Rosário, André Vazão, Helena Volovetska, Yuliya Guimarães, João Tiago Pinto, Fausto J. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Freitas, Ana Teresa Calhau, Conceição Antunes, Gonçalo Araújo, Beatriz Bandeira, Matilde Barreira, Sofia Bazenga, Filipa Braz, Sandra Caldeira, Daniel Santos, Susana Constantino Rosa Faria, Ana Faria, Daniel Fraga, Marta Nogueira-Garcia, Beatriz Gonçalves, Lúcia Kovalchuk, Pavlo Lacerda, Luísa Lopes, Hugo Luís, Daniel Medeiros, Fábio Melo, Ana M.P. Melo-Cristino, José Miranda, Ana Pereira, Clara Pinto, Ana Teresa Pinto, João Proença, Helena Ramos, Angélica Rato, João P.R. Rocha, Filipe Rocha, Júlio César Moreira-Rosário, André Vazão, Helena Volovetska, Yuliya Guimarães, João Tiago Pinto, Fausto J. |
| dc.subject.por.fl_str_mv |
General |
| topic |
General |
| description |
Funding Information: We thank all the study participants, who donated blood and authorized the genetic analysis and the collection of the clinical and phenotypic personal data. This project was supported by the “Fundação para a Ciência e Tecnologia”, program “Research 4 Covid-19 Apoio especial a projetos de implementação rápida para soluções inovadoras de resposta à pandemia de COVID-19”. It was also partially supported by each institution. Publisher Copyright: © 2021, The Author(s). |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-11-15T23:36:39Z 2021-12 2021-12-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/127790 |
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http://hdl.handle.net/10362/127790 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2045-2322 PURE: 34617811 https://doi.org/10.1038/s41598-021-99952-z |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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