Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
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| Publication Date: | 2023 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Download full: | http://hdl.handle.net/10400.18/8652 |
Summary: | Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/ |
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Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in PortugalMpox VirusMPXVViral ZoonosisOutbreakGenomic EpidemiologyViral Genome SequencePortugalInfectious DiseasesInfecções Sistémicas e ZoonosesInfecções EmergentesFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.Springer NatureRepositório Científico do Instituto Nacional de SaúdeBorges, VítorDuque, Mariana PerezMartins, João VieiraVasconcelos, PaulaFerreira, RitaSobral, DanielPelerito, Anade Carvalho, Isabel LopesNúncio, Maria SofiaBorrego, Maria JoséRoemer, CorneliusNeher, Richard A.O’Driscoll, MeganRocha, RaquelLopo, SílviaNeves, RaquelPalminha, PaulaCoelho, LuísNunes, AlexandraIsidro, JoanaPinto, MiguelSantos, João DouradoMixão, VerónicaSantos, DanielaDuarte, SilviaVieira, LuísMartins, FátimaMachado, JorgeVeríssimo, Vítor CabralGrau, BertaPeralta-Santos, AndréNeves, JoséCaldeira, MargaridaPestana, MafaldaFernandes, CândidaCaria, JoãoPinto, RaquelPóvoas, DianaMaltez, FernandoSá, Ana IsabelSalvador, Mafalda BritoTeófilo, EugénioRocha, MiguelMoneti, VirginiaDuque, Luis Miguele Silva, Francisco FerreiraBaptista, TeresaVasconcelos, JoanaCasanova, SaraMansinho, KamalAlves, João VazAlves, JoãoSilva, AntónioAlpalhão, MiguelBrazão, CláudiaSousa, DiogoFilipe, PauloPacheco, PatríciaPeruzzu, Francescade Jesus, Rita PatrocínioFerreira, LuísMendez, JosefinaJordão, SofiaDuarte, FredericoGonçalves, Maria JoãoPena, EduardaSilva, Claúdio NunesGuimarães, André RodriguesTavares, MargaridaFreitas, GraçaCordeiro, RitaGomes, João Paulo2023-10-04T12:16:11Z2023-09-112023-09-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8652engNat Med. 2023 Sep 11. doi: 10.1038/s41591-023-02542-x. Online ahead of print.10.1038/s41591-023-02542-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-17T01:31:02Zoai:repositorio.insa.pt:10400.18/8652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:35.008068Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| spellingShingle |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal Borges, Vítor Mpox Virus MPXV Viral Zoonosis Outbreak Genomic Epidemiology Viral Genome Sequence Portugal Infectious Diseases Infecções Sistémicas e Zoonoses Infecções Emergentes |
| title_short |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_full |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_fullStr |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_full_unstemmed |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_sort |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| author |
Borges, Vítor |
| author_facet |
Borges, Vítor Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| author_role |
author |
| author2 |
Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Borges, Vítor Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| dc.subject.por.fl_str_mv |
Mpox Virus MPXV Viral Zoonosis Outbreak Genomic Epidemiology Viral Genome Sequence Portugal Infectious Diseases Infecções Sistémicas e Zoonoses Infecções Emergentes |
| topic |
Mpox Virus MPXV Viral Zoonosis Outbreak Genomic Epidemiology Viral Genome Sequence Portugal Infectious Diseases Infecções Sistémicas e Zoonoses Infecções Emergentes |
| description |
Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/ |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-10-04T12:16:11Z 2023-09-11 2023-09-11T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8652 |
| url |
http://hdl.handle.net/10400.18/8652 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Nat Med. 2023 Sep 11. doi: 10.1038/s41591-023-02542-x. Online ahead of print. 10.1038/s41591-023-02542-x |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Nature |
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Springer Nature |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133601063763968 |