White matter changes in microstructure associated with a maladaptive response to stress in rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/58135 |
Resumo: | In today's society, every individual is subjected to stressful stimuli with different intensities and duration. This exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. Yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. The neural specificities of this adaptation can be essential to understand the true dynamics of stress as well as to design new approaches to reduce its consequences. In the current work, we employed ex vivo high field diffusion magnetic resonance imaging (MRI) to uncover the differences in white matter properties in the entire brain between Fisher 344 (F344) and Sprague-Dawley (SD) rats, known to present different responses to stress, and to examine the effects of a 2-week repeated inescapable stress paradigm. We applied a tract-based spatial statistics (TBSS) analysis approach to a total of 25 animals. After exposure to stress, SD rats were found to have lower values of corticosterone when compared with F344 rats. Overall, stress was found to lead to an overall increase in fractional anisotropy (FA), on top of a reduction in mean and radial diffusivity (MD and RD) in several white matter bundles of the brain. No effect of strain on the white matter diffusion properties was observed. The strain-by-stress interaction revealed an effect on SD rats in MD, RD and axial diffusivity (AD), with lower diffusion metric levels on stressed animals. These effects were localized on the left side of the brain on the external capsule, corpus callosum, deep cerebral white matter, anterior commissure, endopiriform nucleus, dorsal hippocampus and amygdala fibers. The results possibly reveal an adaptation of the SD strain to the stressful stimuli through synaptic and structural plasticity processes, possibly reflecting learning processes. |
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White matter changes in microstructure associated with a maladaptive response to stress in ratsAmygdalaAnimalsAnisotropyAnterior Cerebellar CommissureBrainCorpus CallosumCorticosteroneDiffusion Magnetic Resonance ImagingExternal CapsuleHippocampusMaleRatsRats, Inbred F344Rats, Sprague-DawleyStress, PsychologicalWhite MatterAdaptation, PhysiologicalScience & TechnologyIn today's society, every individual is subjected to stressful stimuli with different intensities and duration. This exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. Yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. The neural specificities of this adaptation can be essential to understand the true dynamics of stress as well as to design new approaches to reduce its consequences. In the current work, we employed ex vivo high field diffusion magnetic resonance imaging (MRI) to uncover the differences in white matter properties in the entire brain between Fisher 344 (F344) and Sprague-Dawley (SD) rats, known to present different responses to stress, and to examine the effects of a 2-week repeated inescapable stress paradigm. We applied a tract-based spatial statistics (TBSS) analysis approach to a total of 25 animals. After exposure to stress, SD rats were found to have lower values of corticosterone when compared with F344 rats. Overall, stress was found to lead to an overall increase in fractional anisotropy (FA), on top of a reduction in mean and radial diffusivity (MD and RD) in several white matter bundles of the brain. No effect of strain on the white matter diffusion properties was observed. The strain-by-stress interaction revealed an effect on SD rats in MD, RD and axial diffusivity (AD), with lower diffusion metric levels on stressed animals. These effects were localized on the left side of the brain on the external capsule, corpus callosum, deep cerebral white matter, anterior commissure, endopiriform nucleus, dorsal hippocampus and amygdala fibers. The results possibly reveal an adaptation of the SD strain to the stressful stimuli through synaptic and structural plasticity processes, possibly reflecting learning processes.We thank Neurospin (high field MRI center CEA Saclay) for providing its support for MRI acquisition. JB was supported by grants from Fondation pour la Recherche Médicale (FRM) and Groupe Pasteur Mutualité (GPM). This work was supported by a grant from ANR (SIGMA). This work was performed on a platform of France Life Imaging (FLI) network partly funded by the grant ANR-11-INBS-0006. This work and RM were supported by a fellowship of the project FCT-ANR/NEU-OSD/0258/2012 founded by FCT/MEC (www.fct.pt) and by Fundo Europeu de Desenvolvimento Regional (FEDER). AC was supported by a grant from the Fondation NRJ.info:eu-repo/semantics/publishedVersionNature Publishing Group (NPG)Universidade do MinhoMagalhães, R.Bourgin, J.Boumezbeur, F.Marques, P.Bottlaender, M.Poupon, C.Djemaï, B.Duchesnay, E.Mériaux, S.Sousa, NunoJay, T. M.Cachia, A.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58135eng2158-318810.1038/tp.2016.28328117841info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:38:17Zoai:repositorium.sdum.uminho.pt:1822/58135Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:34:41.406050Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
title |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
spellingShingle |
White matter changes in microstructure associated with a maladaptive response to stress in rats Magalhães, R. Amygdala Animals Anisotropy Anterior Cerebellar Commissure Brain Corpus Callosum Corticosterone Diffusion Magnetic Resonance Imaging External Capsule Hippocampus Male Rats Rats, Inbred F344 Rats, Sprague-Dawley Stress, Psychological White Matter Adaptation, Physiological Science & Technology |
title_short |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
title_full |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
title_fullStr |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
title_full_unstemmed |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
title_sort |
White matter changes in microstructure associated with a maladaptive response to stress in rats |
author |
Magalhães, R. |
author_facet |
Magalhães, R. Bourgin, J. Boumezbeur, F. Marques, P. Bottlaender, M. Poupon, C. Djemaï, B. Duchesnay, E. Mériaux, S. Sousa, Nuno Jay, T. M. Cachia, A. |
author_role |
author |
author2 |
Bourgin, J. Boumezbeur, F. Marques, P. Bottlaender, M. Poupon, C. Djemaï, B. Duchesnay, E. Mériaux, S. Sousa, Nuno Jay, T. M. Cachia, A. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Magalhães, R. Bourgin, J. Boumezbeur, F. Marques, P. Bottlaender, M. Poupon, C. Djemaï, B. Duchesnay, E. Mériaux, S. Sousa, Nuno Jay, T. M. Cachia, A. |
dc.subject.por.fl_str_mv |
Amygdala Animals Anisotropy Anterior Cerebellar Commissure Brain Corpus Callosum Corticosterone Diffusion Magnetic Resonance Imaging External Capsule Hippocampus Male Rats Rats, Inbred F344 Rats, Sprague-Dawley Stress, Psychological White Matter Adaptation, Physiological Science & Technology |
topic |
Amygdala Animals Anisotropy Anterior Cerebellar Commissure Brain Corpus Callosum Corticosterone Diffusion Magnetic Resonance Imaging External Capsule Hippocampus Male Rats Rats, Inbred F344 Rats, Sprague-Dawley Stress, Psychological White Matter Adaptation, Physiological Science & Technology |
description |
In today's society, every individual is subjected to stressful stimuli with different intensities and duration. This exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. Yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. The neural specificities of this adaptation can be essential to understand the true dynamics of stress as well as to design new approaches to reduce its consequences. In the current work, we employed ex vivo high field diffusion magnetic resonance imaging (MRI) to uncover the differences in white matter properties in the entire brain between Fisher 344 (F344) and Sprague-Dawley (SD) rats, known to present different responses to stress, and to examine the effects of a 2-week repeated inescapable stress paradigm. We applied a tract-based spatial statistics (TBSS) analysis approach to a total of 25 animals. After exposure to stress, SD rats were found to have lower values of corticosterone when compared with F344 rats. Overall, stress was found to lead to an overall increase in fractional anisotropy (FA), on top of a reduction in mean and radial diffusivity (MD and RD) in several white matter bundles of the brain. No effect of strain on the white matter diffusion properties was observed. The strain-by-stress interaction revealed an effect on SD rats in MD, RD and axial diffusivity (AD), with lower diffusion metric levels on stressed animals. These effects were localized on the left side of the brain on the external capsule, corpus callosum, deep cerebral white matter, anterior commissure, endopiriform nucleus, dorsal hippocampus and amygdala fibers. The results possibly reveal an adaptation of the SD strain to the stressful stimuli through synaptic and structural plasticity processes, possibly reflecting learning processes. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/58135 |
url |
http://hdl.handle.net/1822/58135 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2158-3188 10.1038/tp.2016.283 28117841 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group (NPG) |
publisher.none.fl_str_mv |
Nature Publishing Group (NPG) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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