Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism

Bibliographic Details
Main Author: Marques,Filipa Carlota
Publication Date: 2014
Other Authors: Viveiro,Carolina, Castro,Isabel
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000300008
Summary: Background: Rhabdomyolysis is a condition defined by necrosis of muscle cell and release of its contents into the systemic circulation. The fibric acid derivative fenofibrate is indicated in the treatment of hyperlipidaemia in adults. Fenofibrate monotherapy-induced rhabdomyolysis is rare. The presence of chronic renal failure and hypothyroidism are among the primary factors for rhabdomyolysis. Case: Our case study is about an adolescent with chronic renal failure, severe hypertriglyceridemia and hypothyroidism who developed rhabdomyolysis and irreversible deterioration of kidney function after monotherapy with fenofibrate. The patient required renal replacement therapy using haemodialysis and kidney transplant. Conclusion: This case study is of the highest importance to warn against the adverse events associated with fenofibrate therapy and to alert to the need of a rigorous control of its use when risk factors are present.
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spelling Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidismChronic renal failurefenofibratehypothyroidismrhabdomyolysisBackground: Rhabdomyolysis is a condition defined by necrosis of muscle cell and release of its contents into the systemic circulation. The fibric acid derivative fenofibrate is indicated in the treatment of hyperlipidaemia in adults. Fenofibrate monotherapy-induced rhabdomyolysis is rare. The presence of chronic renal failure and hypothyroidism are among the primary factors for rhabdomyolysis. Case: Our case study is about an adolescent with chronic renal failure, severe hypertriglyceridemia and hypothyroidism who developed rhabdomyolysis and irreversible deterioration of kidney function after monotherapy with fenofibrate. The patient required renal replacement therapy using haemodialysis and kidney transplant. Conclusion: This case study is of the highest importance to warn against the adverse events associated with fenofibrate therapy and to alert to the need of a rigorous control of its use when risk factors are present.Sociedade Portuguesa de Nefrologia2014-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000300008Portuguese Journal of Nephrology & Hypertension v.28 n.3 2014reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000300008Marques,Filipa CarlotaViveiro,CarolinaCastro,Isabelinfo:eu-repo/semantics/openAccess2024-02-06T17:04:46Zoai:scielo:S0872-01692014000300008Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:53.034557Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
title Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
spellingShingle Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
Marques,Filipa Carlota
Chronic renal failure
fenofibrate
hypothyroidism
rhabdomyolysis
title_short Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
title_full Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
title_fullStr Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
title_full_unstemmed Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
title_sort Fenofibrate-induced rhabdomyolysis in an adolescent with chronic renal failure and hypothyroidism
author Marques,Filipa Carlota
author_facet Marques,Filipa Carlota
Viveiro,Carolina
Castro,Isabel
author_role author
author2 Viveiro,Carolina
Castro,Isabel
author2_role author
author
dc.contributor.author.fl_str_mv Marques,Filipa Carlota
Viveiro,Carolina
Castro,Isabel
dc.subject.por.fl_str_mv Chronic renal failure
fenofibrate
hypothyroidism
rhabdomyolysis
topic Chronic renal failure
fenofibrate
hypothyroidism
rhabdomyolysis
description Background: Rhabdomyolysis is a condition defined by necrosis of muscle cell and release of its contents into the systemic circulation. The fibric acid derivative fenofibrate is indicated in the treatment of hyperlipidaemia in adults. Fenofibrate monotherapy-induced rhabdomyolysis is rare. The presence of chronic renal failure and hypothyroidism are among the primary factors for rhabdomyolysis. Case: Our case study is about an adolescent with chronic renal failure, severe hypertriglyceridemia and hypothyroidism who developed rhabdomyolysis and irreversible deterioration of kidney function after monotherapy with fenofibrate. The patient required renal replacement therapy using haemodialysis and kidney transplant. Conclusion: This case study is of the highest importance to warn against the adverse events associated with fenofibrate therapy and to alert to the need of a rigorous control of its use when risk factors are present.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000300008
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692014000300008
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.28 n.3 2014
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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