THOR is a targetable epigenetic biomarker with clinical implications in breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/18744 |
Resumo: | Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demon‑ strate the urgent need of novel and more efective diagnostic and therapeutic options. Limitless self-renewal is a hallmark of cancer, governed by telomere maintenance. In around 95% of BC cases, this process is achieved by telom‑ erase reactivation through upregulation of the human telomerase reverse transcriptase (hTERT). The hypermethylation of a specifc region within the hTERT promoter, termed TERT hypermethylated oncological region (THOR) has been associated with increased hTERT expression in cancer. However, its biological role and clinical potential in BC have never been studied to the best of our knowledge. Therefore, we aimed to investigate the role of THOR as a biomarker and explore the functional impact of THOR methylation status in hTERT upregulation in BC. |
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THOR is a targetable epigenetic biomarker with clinical implications in breast cancerBreast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demon‑ strate the urgent need of novel and more efective diagnostic and therapeutic options. Limitless self-renewal is a hallmark of cancer, governed by telomere maintenance. In around 95% of BC cases, this process is achieved by telom‑ erase reactivation through upregulation of the human telomerase reverse transcriptase (hTERT). The hypermethylation of a specifc region within the hTERT promoter, termed TERT hypermethylated oncological region (THOR) has been associated with increased hTERT expression in cancer. However, its biological role and clinical potential in BC have never been studied to the best of our knowledge. Therefore, we aimed to investigate the role of THOR as a biomarker and explore the functional impact of THOR methylation status in hTERT upregulation in BC.MDPISapientiaApolónio, JoanaDias, João S.Fernandes, Mónica T.Komosa, MartinLipman, TatianaZhang, Cindy H.Leão, RicardoLee, DonghyunNunes, Nuno M.Maia, Ana-TeresaMorera, José L.Vicioso, LuisTabori, UriCastelo-Branco, Pedro2023-01-06T13:24:20Z2022-12-182023-01-01T04:54:15Z2022-12-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/18744engClinical Epigenetics. 2022 Dec 18;14(1):17810.1186/s13148-022-01396-31868-7083info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:31:03ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
title |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
spellingShingle |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer Apolónio, Joana |
title_short |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
title_full |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
title_fullStr |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
title_full_unstemmed |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
title_sort |
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer |
author |
Apolónio, Joana |
author_facet |
Apolónio, Joana Dias, João S. Fernandes, Mónica T. Komosa, Martin Lipman, Tatiana Zhang, Cindy H. Leão, Ricardo Lee, Donghyun Nunes, Nuno M. Maia, Ana-Teresa Morera, José L. Vicioso, Luis Tabori, Uri Castelo-Branco, Pedro |
author_role |
author |
author2 |
Dias, João S. Fernandes, Mónica T. Komosa, Martin Lipman, Tatiana Zhang, Cindy H. Leão, Ricardo Lee, Donghyun Nunes, Nuno M. Maia, Ana-Teresa Morera, José L. Vicioso, Luis Tabori, Uri Castelo-Branco, Pedro |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Apolónio, Joana Dias, João S. Fernandes, Mónica T. Komosa, Martin Lipman, Tatiana Zhang, Cindy H. Leão, Ricardo Lee, Donghyun Nunes, Nuno M. Maia, Ana-Teresa Morera, José L. Vicioso, Luis Tabori, Uri Castelo-Branco, Pedro |
description |
Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demon‑ strate the urgent need of novel and more efective diagnostic and therapeutic options. Limitless self-renewal is a hallmark of cancer, governed by telomere maintenance. In around 95% of BC cases, this process is achieved by telom‑ erase reactivation through upregulation of the human telomerase reverse transcriptase (hTERT). The hypermethylation of a specifc region within the hTERT promoter, termed TERT hypermethylated oncological region (THOR) has been associated with increased hTERT expression in cancer. However, its biological role and clinical potential in BC have never been studied to the best of our knowledge. Therefore, we aimed to investigate the role of THOR as a biomarker and explore the functional impact of THOR methylation status in hTERT upregulation in BC. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-18 2022-12-18T00:00:00Z 2023-01-06T13:24:20Z 2023-01-01T04:54:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/18744 |
url |
http://hdl.handle.net/10400.1/18744 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Epigenetics. 2022 Dec 18;14(1):178 10.1186/s13148-022-01396-3 1868-7083 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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