Language impairment in the genetic forms of behavioural variant frontotemporal dementia

Detalhes bibliográficos
Autor(a) principal: Samra, Kiran
Data de Publicação: 2022
Outros Autores: MacDougall, Amy M., Bouzigues, Arabella, Bocchetta, Martina, Cash, David M., Greaves, Caroline V., Convery, Rhian S., van Swieten, John C., Seelaar, Harro, Jiskoot, Lize, Moreno, Fermin, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Sanchez-Valle, Raquel, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Laforce, Robert, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Graff, Caroline, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Masellis, Mario, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Tartaglia, Maria Carmela, Rowe, James B., Borroni, Barbara, Finger, Elizabeth, Synofzik, Matthis, Galimberti, Daniela, Vandenberghe, Rik, De Mendonça, Alexandre, Butler, Christopher R., Gerhard, Alexander, Ducharme, Simon, Le Ber, Isabelle, Tiraboschi, Pietro, Santana, Isabel, Pasquier, Florence, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Rohrer, Jonathan D., Russell, Lucy L., Nelson, Annabel, Thomas, David L., Todd, Emily, Benotmane, Hanya, Nicholas, Jennifer, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M., Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B., Miltenberger-Miltenyi, Gabriel, Simões Do Couto, Frederico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55658
Resumo: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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spelling Language impairment in the genetic forms of behavioural variant frontotemporal dementiaC9orf72Frontotemporal dementiaGeneticsLanguageProgranulinTau© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Background: Behavioural variant fronto-temporal dementia (bvFTD) is characterised by a progressive change in personality in association with atrophy of the frontal and temporal lobes. Whilst language impairment has been described in people with bvFTD, little is currently known about the extent or type of linguistic difficulties that occur, particularly in the genetic forms. Methods: Participants with genetic bvFTD along with healthy controls were recruited from the international multicentre Genetic FTD Initiative (GENFI). Linguistic symptoms were assessed using items from the Progressive Aphasia Severity Scale (PASS). Additionally, participants undertook the Boston Naming Test (BNT), modified Camel and Cactus Test (mCCT) and a category fluency test. Participants underwent a 3T volumetric T1-weighted MRI, with language network regional brain volumes measured and compared between the genetic groups and controls. Results: 76% of the genetic bvFTD cohort had impairment in at least one language symptom: 83% C9orf72, 80% MAPT and 56% GRN mutation carriers. All three genetic groups had significantly impaired functional communication, decreased fluency, and impaired sentence comprehension. C9orf72 mutation carriers also had significantly impaired articulation and word retrieval as well as dysgraphia whilst the MAPT mutation group also had impaired word retrieval and single word comprehension. All three groups had difficulties with naming, semantic knowledge and verbal fluency. Atrophy in key left perisylvian language regions differed between the groups, with generalised involvement in the C9orf72 group and more focal temporal and insula involvement in the other groups. Correlates of language symptoms and test scores also differed between the groups. Conclusions: Language deficits exist in a substantial proportion of people with familial bvFTD across all three genetic groups. Significant atrophy is seen in the dominant perisylvian language areas and correlates with language impairments within each of the genetic groups. Improved understanding of the language phenotype in the main genetic bvFTD subtypes will be helpful in future studies, particularly in clinical trials where accurate stratification and monitoring of disease progression is required.Springer NatureRepositório da Universidade de LisboaSamra, KiranMacDougall, Amy M.Bouzigues, ArabellaBocchetta, MartinaCash, David M.Greaves, Caroline V.Convery, Rhian S.van Swieten, John C.Seelaar, HarroJiskoot, LizeMoreno, FerminGabilondo, AlazneGorostidi, AnaVillanua, JorgeCañada, MartaTainta, MikelZulaica, MirenBarandiaran, MyriamAlves, PatriciaBender, BenjaminWilke, CarloSanchez-Valle, RaquelGraf, LisaVogels, AnnickVandenbulcke, MathieuVan Damme, PhilipBruffaerts, RosePoesen, KoenRosa-Neto, PedroGauthier, SergeCamuzat, AgnèsBrice, AlexisLaforce, RobertBertrand, AnneFunkiewiez, AurélieRinaldi, DaisySaracino, DarioColliot, OlivierSayah, SabrinaPrix, CatharinaWlasich, ElisabethWagemann, OliviaLoosli, SandraGraff, CarolineSchönecker, SonjaHoegen, TobiasLombardi, JolinaAnderl-Straub, SarahRollin, AdelineKuchcinski, GregoryBertoux, MaximeLebouvier, ThibaudDeramecourt, VincentSantiago, BeatrizMasellis, MarioDuro, DianaLeitão, Maria JoãoAlmeida, Maria RosarioTábuas-Pereira, MiguelAfonso, SóniaTartaglia, Maria CarmelaRowe, James B.Borroni, BarbaraFinger, ElizabethSynofzik, MatthisGalimberti, DanielaVandenberghe, RikDe Mendonça, AlexandreButler, Christopher R.Gerhard, AlexanderDucharme, SimonLe Ber, IsabelleTiraboschi, PietroSantana, IsabelPasquier, FlorenceLevin, JohannesOtto, MarkusSorbi, SandroRohrer, Jonathan D.Russell, Lucy L.Nelson, AnnabelThomas, David L.Todd, EmilyBenotmane, HanyaNicholas, JenniferShafei, RachelleTimberlake, CarolynCope, ThomasRittman, TimothyBenussi, AlbertoPremi, EnricoGasparotti, RobertoArchetti, SilvanaGazzina, StefanoCantoni, ValentinaArighi, AndreaFenoglio, ChiaraScarpini, ElioFumagalli, GiorgioBorracci, VittoriaRossi, GiacominaGiaccone, GiorgioDi Fede, GiuseppeCaroppo, PaolaTiraboschi, PietroPrioni, SaraRedaelli, VeronicaTang-Wai, DavidRogaeva, EkaterinaCastelo-Branco, MiguelFreedman, MorrisKeren, RonBlack, SandraMitchell, SaraShoesmith, ChristenBartha, RobartRademakers, RosaPoos, JackiePapma, Janne M.Giannini, Luciavan Minkelen, RickPijnenburg, YolandeNacmias, BenedettaFerrari, CamillaPolito, CristinaLombardi, GemmaBessi, ValentinaVeldsman, MicheleAndersson, ChristinThonberg, HakanÖijerstedt, LinnJelic, VesnaThompson, PaulLangheinrich, TobiasLladó, AlbertAntonell, AnnaOlives, JaumeBalasa, MirceaBargalló, NuriaBorrego-Ecija, SergiVerdelho, AnaMaruta, CarolinaFerreira, Catarina B.Miltenberger-Miltenyi, GabrielSimões Do Couto, Frederico2023-01-05T12:48:42Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55658engJ Neurol. 2022 Dec 200340-535410.1007/s00415-022-11512-11432-1459info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:31Zoai:repositorio.ul.pt:10451/55658Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:09.845978Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Language impairment in the genetic forms of behavioural variant frontotemporal dementia
title Language impairment in the genetic forms of behavioural variant frontotemporal dementia
spellingShingle Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Samra, Kiran
C9orf72
Frontotemporal dementia
Genetics
Language
Progranulin
Tau
title_short Language impairment in the genetic forms of behavioural variant frontotemporal dementia
title_full Language impairment in the genetic forms of behavioural variant frontotemporal dementia
title_fullStr Language impairment in the genetic forms of behavioural variant frontotemporal dementia
title_full_unstemmed Language impairment in the genetic forms of behavioural variant frontotemporal dementia
title_sort Language impairment in the genetic forms of behavioural variant frontotemporal dementia
author Samra, Kiran
author_facet Samra, Kiran
MacDougall, Amy M.
Bouzigues, Arabella
Bocchetta, Martina
Cash, David M.
Greaves, Caroline V.
Convery, Rhian S.
van Swieten, John C.
Seelaar, Harro
Jiskoot, Lize
Moreno, Fermin
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Sanchez-Valle, Raquel
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Laforce, Robert
Bertrand, Anne
Funkiewiez, Aurélie
Rinaldi, Daisy
Saracino, Dario
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Loosli, Sandra
Graff, Caroline
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Deramecourt, Vincent
Santiago, Beatriz
Masellis, Mario
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Tartaglia, Maria Carmela
Rowe, James B.
Borroni, Barbara
Finger, Elizabeth
Synofzik, Matthis
Galimberti, Daniela
Vandenberghe, Rik
De Mendonça, Alexandre
Butler, Christopher R.
Gerhard, Alexander
Ducharme, Simon
Le Ber, Isabelle
Tiraboschi, Pietro
Santana, Isabel
Pasquier, Florence
Levin, Johannes
Otto, Markus
Sorbi, Sandro
Rohrer, Jonathan D.
Russell, Lucy L.
Nelson, Annabel
Thomas, David L.
Todd, Emily
Benotmane, Hanya
Nicholas, Jennifer
Shafei, Rachelle
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Di Fede, Giuseppe
Caroppo, Paola
Prioni, Sara
Redaelli, Veronica
Tang-Wai, David
Rogaeva, Ekaterina
Castelo-Branco, Miguel
Freedman, Morris
Keren, Ron
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Poos, Jackie
Papma, Janne M.
Giannini, Lucia
van Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bessi, Valentina
Veldsman, Michele
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Langheinrich, Tobias
Lladó, Albert
Antonell, Anna
Olives, Jaume
Balasa, Mircea
Bargalló, Nuria
Borrego-Ecija, Sergi
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
author_role author
author2 MacDougall, Amy M.
Bouzigues, Arabella
Bocchetta, Martina
Cash, David M.
Greaves, Caroline V.
Convery, Rhian S.
van Swieten, John C.
Seelaar, Harro
Jiskoot, Lize
Moreno, Fermin
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Sanchez-Valle, Raquel
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Laforce, Robert
Bertrand, Anne
Funkiewiez, Aurélie
Rinaldi, Daisy
Saracino, Dario
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Loosli, Sandra
Graff, Caroline
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Deramecourt, Vincent
Santiago, Beatriz
Masellis, Mario
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Tartaglia, Maria Carmela
Rowe, James B.
Borroni, Barbara
Finger, Elizabeth
Synofzik, Matthis
Galimberti, Daniela
Vandenberghe, Rik
De Mendonça, Alexandre
Butler, Christopher R.
Gerhard, Alexander
Ducharme, Simon
Le Ber, Isabelle
Tiraboschi, Pietro
Santana, Isabel
Pasquier, Florence
Levin, Johannes
Otto, Markus
Sorbi, Sandro
Rohrer, Jonathan D.
Russell, Lucy L.
Nelson, Annabel
Thomas, David L.
Todd, Emily
Benotmane, Hanya
Nicholas, Jennifer
Shafei, Rachelle
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Di Fede, Giuseppe
Caroppo, Paola
Prioni, Sara
Redaelli, Veronica
Tang-Wai, David
Rogaeva, Ekaterina
Castelo-Branco, Miguel
Freedman, Morris
Keren, Ron
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Poos, Jackie
Papma, Janne M.
Giannini, Lucia
van Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bessi, Valentina
Veldsman, Michele
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Langheinrich, Tobias
Lladó, Albert
Antonell, Anna
Olives, Jaume
Balasa, Mircea
Bargalló, Nuria
Borrego-Ecija, Sergi
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Samra, Kiran
MacDougall, Amy M.
Bouzigues, Arabella
Bocchetta, Martina
Cash, David M.
Greaves, Caroline V.
Convery, Rhian S.
van Swieten, John C.
Seelaar, Harro
Jiskoot, Lize
Moreno, Fermin
Gabilondo, Alazne
Gorostidi, Ana
Villanua, Jorge
Cañada, Marta
Tainta, Mikel
Zulaica, Miren
Barandiaran, Myriam
Alves, Patricia
Bender, Benjamin
Wilke, Carlo
Sanchez-Valle, Raquel
Graf, Lisa
Vogels, Annick
Vandenbulcke, Mathieu
Van Damme, Philip
Bruffaerts, Rose
Poesen, Koen
Rosa-Neto, Pedro
Gauthier, Serge
Camuzat, Agnès
Brice, Alexis
Laforce, Robert
Bertrand, Anne
Funkiewiez, Aurélie
Rinaldi, Daisy
Saracino, Dario
Colliot, Olivier
Sayah, Sabrina
Prix, Catharina
Wlasich, Elisabeth
Wagemann, Olivia
Loosli, Sandra
Graff, Caroline
Schönecker, Sonja
Hoegen, Tobias
Lombardi, Jolina
Anderl-Straub, Sarah
Rollin, Adeline
Kuchcinski, Gregory
Bertoux, Maxime
Lebouvier, Thibaud
Deramecourt, Vincent
Santiago, Beatriz
Masellis, Mario
Duro, Diana
Leitão, Maria João
Almeida, Maria Rosario
Tábuas-Pereira, Miguel
Afonso, Sónia
Tartaglia, Maria Carmela
Rowe, James B.
Borroni, Barbara
Finger, Elizabeth
Synofzik, Matthis
Galimberti, Daniela
Vandenberghe, Rik
De Mendonça, Alexandre
Butler, Christopher R.
Gerhard, Alexander
Ducharme, Simon
Le Ber, Isabelle
Tiraboschi, Pietro
Santana, Isabel
Pasquier, Florence
Levin, Johannes
Otto, Markus
Sorbi, Sandro
Rohrer, Jonathan D.
Russell, Lucy L.
Nelson, Annabel
Thomas, David L.
Todd, Emily
Benotmane, Hanya
Nicholas, Jennifer
Shafei, Rachelle
Timberlake, Carolyn
Cope, Thomas
Rittman, Timothy
Benussi, Alberto
Premi, Enrico
Gasparotti, Roberto
Archetti, Silvana
Gazzina, Stefano
Cantoni, Valentina
Arighi, Andrea
Fenoglio, Chiara
Scarpini, Elio
Fumagalli, Giorgio
Borracci, Vittoria
Rossi, Giacomina
Giaccone, Giorgio
Di Fede, Giuseppe
Caroppo, Paola
Tiraboschi, Pietro
Prioni, Sara
Redaelli, Veronica
Tang-Wai, David
Rogaeva, Ekaterina
Castelo-Branco, Miguel
Freedman, Morris
Keren, Ron
Black, Sandra
Mitchell, Sara
Shoesmith, Christen
Bartha, Robart
Rademakers, Rosa
Poos, Jackie
Papma, Janne M.
Giannini, Lucia
van Minkelen, Rick
Pijnenburg, Yolande
Nacmias, Benedetta
Ferrari, Camilla
Polito, Cristina
Lombardi, Gemma
Bessi, Valentina
Veldsman, Michele
Andersson, Christin
Thonberg, Hakan
Öijerstedt, Linn
Jelic, Vesna
Thompson, Paul
Langheinrich, Tobias
Lladó, Albert
Antonell, Anna
Olives, Jaume
Balasa, Mircea
Bargalló, Nuria
Borrego-Ecija, Sergi
Verdelho, Ana
Maruta, Carolina
Ferreira, Catarina B.
Miltenberger-Miltenyi, Gabriel
Simões Do Couto, Frederico
dc.subject.por.fl_str_mv C9orf72
Frontotemporal dementia
Genetics
Language
Progranulin
Tau
topic C9orf72
Frontotemporal dementia
Genetics
Language
Progranulin
Tau
description © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-01-05T12:48:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55658
url http://hdl.handle.net/10451/55658
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neurol. 2022 Dec 20
0340-5354
10.1007/s00415-022-11512-1
1432-1459
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
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