The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/12659 |
Resumo: | Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman=0.517, p=0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction. |
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The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severityRhinomanometryPeak nasal inspiratory flow (PNIF)Chronic sinusitisPolyp patientsAlthough the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman=0.517, p=0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.Nature Publishing GroupRCIPLAraújo-Martins, JoséBrás-Geraldes, CarlosNeuparth, Nuno2021-01-21T10:26:02Z2020-07-292020-07-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/12659engMARTINS, José Araújo; GERALDES, Carlos Brás; NEUPARTH, Nuno – The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity. Scientific Reports. ISSN 2045-2322. Vol. 10, N.º 1 (2020), pp. 1-92045-232210.1038/s41598-020-69693-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:06:01Zoai:repositorio.ipl.pt:10400.21/12659Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:20:42.353170Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
title |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
spellingShingle |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity Araújo-Martins, José Rhinomanometry Peak nasal inspiratory flow (PNIF) Chronic sinusitis Polyp patients |
title_short |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
title_full |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
title_fullStr |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
title_full_unstemmed |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
title_sort |
The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity |
author |
Araújo-Martins, José |
author_facet |
Araújo-Martins, José Brás-Geraldes, Carlos Neuparth, Nuno |
author_role |
author |
author2 |
Brás-Geraldes, Carlos Neuparth, Nuno |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Araújo-Martins, José Brás-Geraldes, Carlos Neuparth, Nuno |
dc.subject.por.fl_str_mv |
Rhinomanometry Peak nasal inspiratory flow (PNIF) Chronic sinusitis Polyp patients |
topic |
Rhinomanometry Peak nasal inspiratory flow (PNIF) Chronic sinusitis Polyp patients |
description |
Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman=0.517, p=0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-29 2020-07-29T00:00:00Z 2021-01-21T10:26:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/12659 |
url |
http://hdl.handle.net/10400.21/12659 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
MARTINS, José Araújo; GERALDES, Carlos Brás; NEUPARTH, Nuno – The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity. Scientific Reports. ISSN 2045-2322. Vol. 10, N.º 1 (2020), pp. 1-9 2045-2322 10.1038/s41598-020-69693-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133476585209856 |