Meniscal Allograft Transplants and New Scaffolding Techniques

Detalhes bibliográficos
Autor(a) principal: Pereira, H.
Data de Publicação: 2019
Outros Autores: Cengiz, I. F., Gomes, S., Espregueira-Mendes, João, Ripoll, P. L., Monllau, J. C., Reis, R. L., Oliveira, Joaquim M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/60508
Resumo: A Clinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joint homeostasis, meniscus preservation and/or repair, whenever indicated and possible, are currently the guidelines for management. However, when repair is no longer possible or when facing the fact of the previous partial, subtotal or total loss of the meniscus, meniscus replacement has proved its clinical value. Nevertheless, meniscectomy remains amongst the most frequent orthopaedic procedures. Meniscus replacement is currently possible by means of meniscal allograft transplantation (MAT) which provides replacement of the whole meniscus with or without bone plugs/slots. Partial replacement has been achieved by means of meniscal scaffolds (mainly collagen or polyurethane-based). Despite the favourable clinical outcomes, it is still debatable whether MAT is capable of preventing progression to osteoarthritis. Moreover, current scaffolds have shown some fundamental limitations, such as the fact that the newly formed tissue may be different from the native fibrocartilage of the meniscus. Regenerative tissue engineering strategies have been used in an attempt to provide a new generation of meniscal implants, either for partial or total replacement. The goal is to provide biomaterials (acellular or cell-seeded constructs) which provide the biomechanical properties but also the biological features to replace the loss of native tissue. Moreover, these approaches include possibilities for patient-specific implants of correct size and shape, as well as advanced strategies combining cells, bioactive agents, hydrogels or gene therapy. Herein, the clinical evidence and tips concerning MAT, currently available meniscus scaffolds and future perspectives are discussed.
id RCAP_93db8d33fe4ad798fad370cf27fca54d
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/60508
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Meniscal Allograft Transplants and New Scaffolding TechniquesAllo-graft transplantation (MAT)Meniscal repairMeniscectomyMeniscusPartial meniscus replacementScaffoldTissue engineering and regenerative medicinemeniscus allograft transplantation (MAT)Ciências Médicas::Biotecnologia MédicaScience & TechnologyA Clinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joint homeostasis, meniscus preservation and/or repair, whenever indicated and possible, are currently the guidelines for management. However, when repair is no longer possible or when facing the fact of the previous partial, subtotal or total loss of the meniscus, meniscus replacement has proved its clinical value. Nevertheless, meniscectomy remains amongst the most frequent orthopaedic procedures. Meniscus replacement is currently possible by means of meniscal allograft transplantation (MAT) which provides replacement of the whole meniscus with or without bone plugs/slots. Partial replacement has been achieved by means of meniscal scaffolds (mainly collagen or polyurethane-based). Despite the favourable clinical outcomes, it is still debatable whether MAT is capable of preventing progression to osteoarthritis. Moreover, current scaffolds have shown some fundamental limitations, such as the fact that the newly formed tissue may be different from the native fibrocartilage of the meniscus. Regenerative tissue engineering strategies have been used in an attempt to provide a new generation of meniscal implants, either for partial or total replacement. The goal is to provide biomaterials (acellular or cell-seeded constructs) which provide the biomechanical properties but also the biological features to replace the loss of native tissue. Moreover, these approaches include possibilities for patient-specific implants of correct size and shape, as well as advanced strategies combining cells, bioactive agents, hydrogels or gene therapy. Herein, the clinical evidence and tips concerning MAT, currently available meniscus scaffolds and future perspectives are discussed.I. F. Cengiz thanks the Portuguese Foundation for Science and Technology (FCT) for the Ph.D. scholarship (SFRH/BD/99555/2014). J. M. Oliveira also thanks the FCT for the funds provided under the program Investigador FCT 2012 and 2015 (IF/00423/2012 and IF/01285/2015).info:eu-repo/semantics/publishedVersionBritish Editorial Society of Bone and Joint SurgeryUniversidade do MinhoPereira, H.Cengiz, I. F.Gomes, S.Espregueira-Mendes, JoãoRipoll, P. L.Monllau, J. C.Reis, R. L.Oliveira, Joaquim M.2019-062019-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/60508engPereira H., Cengiz I. F., Gomes S., Espregueira-Mendes J., Ripoll P. L., Monllau J. C., Reis R. L., Oliveira J. M. Meniscal Allograft Transplants and New Scaffolding Techniques, EFORT Open Reviews, doi:10.1302/2058-5241.4.180103, 20192058-524110.1302/2058-5241.4.180103https://online.boneandjoint.org.uk/doi/full/10.1302/2058-5241.4.180103info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:37:36Zoai:repositorium.sdum.uminho.pt:1822/60508Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:33:55.606558Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Meniscal Allograft Transplants and New Scaffolding Techniques
title Meniscal Allograft Transplants and New Scaffolding Techniques
spellingShingle Meniscal Allograft Transplants and New Scaffolding Techniques
Pereira, H.
Allo-graft transplantation (MAT)
Meniscal repair
Meniscectomy
Meniscus
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
meniscus allograft transplantation (MAT)
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Meniscal Allograft Transplants and New Scaffolding Techniques
title_full Meniscal Allograft Transplants and New Scaffolding Techniques
title_fullStr Meniscal Allograft Transplants and New Scaffolding Techniques
title_full_unstemmed Meniscal Allograft Transplants and New Scaffolding Techniques
title_sort Meniscal Allograft Transplants and New Scaffolding Techniques
author Pereira, H.
author_facet Pereira, H.
Cengiz, I. F.
Gomes, S.
Espregueira-Mendes, João
Ripoll, P. L.
Monllau, J. C.
Reis, R. L.
Oliveira, Joaquim M.
author_role author
author2 Cengiz, I. F.
Gomes, S.
Espregueira-Mendes, João
Ripoll, P. L.
Monllau, J. C.
Reis, R. L.
Oliveira, Joaquim M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pereira, H.
Cengiz, I. F.
Gomes, S.
Espregueira-Mendes, João
Ripoll, P. L.
Monllau, J. C.
Reis, R. L.
Oliveira, Joaquim M.
dc.subject.por.fl_str_mv Allo-graft transplantation (MAT)
Meniscal repair
Meniscectomy
Meniscus
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
meniscus allograft transplantation (MAT)
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Allo-graft transplantation (MAT)
Meniscal repair
Meniscectomy
Meniscus
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
meniscus allograft transplantation (MAT)
Ciências Médicas::Biotecnologia Médica
Science & Technology
description A Clinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joint homeostasis, meniscus preservation and/or repair, whenever indicated and possible, are currently the guidelines for management. However, when repair is no longer possible or when facing the fact of the previous partial, subtotal or total loss of the meniscus, meniscus replacement has proved its clinical value. Nevertheless, meniscectomy remains amongst the most frequent orthopaedic procedures. Meniscus replacement is currently possible by means of meniscal allograft transplantation (MAT) which provides replacement of the whole meniscus with or without bone plugs/slots. Partial replacement has been achieved by means of meniscal scaffolds (mainly collagen or polyurethane-based). Despite the favourable clinical outcomes, it is still debatable whether MAT is capable of preventing progression to osteoarthritis. Moreover, current scaffolds have shown some fundamental limitations, such as the fact that the newly formed tissue may be different from the native fibrocartilage of the meniscus. Regenerative tissue engineering strategies have been used in an attempt to provide a new generation of meniscal implants, either for partial or total replacement. The goal is to provide biomaterials (acellular or cell-seeded constructs) which provide the biomechanical properties but also the biological features to replace the loss of native tissue. Moreover, these approaches include possibilities for patient-specific implants of correct size and shape, as well as advanced strategies combining cells, bioactive agents, hydrogels or gene therapy. Herein, the clinical evidence and tips concerning MAT, currently available meniscus scaffolds and future perspectives are discussed.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
2019-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/60508
url http://hdl.handle.net/1822/60508
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira H., Cengiz I. F., Gomes S., Espregueira-Mendes J., Ripoll P. L., Monllau J. C., Reis R. L., Oliveira J. M. Meniscal Allograft Transplants and New Scaffolding Techniques, EFORT Open Reviews, doi:10.1302/2058-5241.4.180103, 2019
2058-5241
10.1302/2058-5241.4.180103
https://online.boneandjoint.org.uk/doi/full/10.1302/2058-5241.4.180103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv British Editorial Society of Bone and Joint Surgery
publisher.none.fl_str_mv British Editorial Society of Bone and Joint Surgery
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132859509768192