Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3325 |
Resumo: | Bicuspid aortic valve (BAV) aortopathy remains of difficult clinical management due to its heterogeneity and further assessment of related aortic hemodynamics is necessary. The aim of this study was to assess systolic hemodynamic indexes and wall stresses in patients with diverse BAV phenotypes and dilated ascending aortas. The aortic geometry was reconstructed from patient-specific images while the aortic valve was generated based on patient-specific measurements. Physiologic material properties and boundary conditions were applied and fully coupled fluid-structure interaction (FSI) analysis were conducted. Our dilated aortic models were characterized by the presence of abnormal hemodynamics with elevated degrees of flow skewness and eccentricity, regardless of BAV morphotype. Retrograde flow was also present. Both features, predicted by flow angle and flow reversal ratios, were consistently higher than those reported for non-dilated aortas. Right-handed helical flow was present, as well as elevated wall shear stress (WSS) on the outer ascending aortic wall. Our results suggest that the abnormal flow associated with BAV may play a role in aortic enlargement and progress it further on already dilated aortas. |
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Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated AortasAortaAortic DiseasesAortic ValveCase-Control StudiesDilatation, PathologicHeart Valve DiseasesHemodynamicsHumansModels, CardiovascularStress, MechanicalSystoleHSM CARBicuspid aortic valve (BAV) aortopathy remains of difficult clinical management due to its heterogeneity and further assessment of related aortic hemodynamics is necessary. The aim of this study was to assess systolic hemodynamic indexes and wall stresses in patients with diverse BAV phenotypes and dilated ascending aortas. The aortic geometry was reconstructed from patient-specific images while the aortic valve was generated based on patient-specific measurements. Physiologic material properties and boundary conditions were applied and fully coupled fluid-structure interaction (FSI) analysis were conducted. Our dilated aortic models were characterized by the presence of abnormal hemodynamics with elevated degrees of flow skewness and eccentricity, regardless of BAV morphotype. Retrograde flow was also present. Both features, predicted by flow angle and flow reversal ratios, were consistently higher than those reported for non-dilated aortas. Right-handed helical flow was present, as well as elevated wall shear stress (WSS) on the outer ascending aortic wall. Our results suggest that the abnormal flow associated with BAV may play a role in aortic enlargement and progress it further on already dilated aortas.Taylor & FrancisRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEOliveira, DAguiar Rosa, STiago, JCruz Ferreira, RAgapito, ASequeira, A2019-10-11T11:31:32Z2019-062019-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3325engComput Methods Biomech Biomed Engin. 2019 Jun;22(8):815-826.10.1080/10255842.2019.1597860info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:42:24ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
title |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
spellingShingle |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas Oliveira, D Aorta Aortic Diseases Aortic Valve Case-Control Studies Dilatation, Pathologic Heart Valve Diseases Hemodynamics Humans Models, Cardiovascular Stress, Mechanical Systole HSM CAR |
title_short |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
title_full |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
title_fullStr |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
title_full_unstemmed |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
title_sort |
Bicuspid Aortic Valve Aortopathies: an Hemodynamics Characterization in Dilated Aortas |
author |
Oliveira, D |
author_facet |
Oliveira, D Aguiar Rosa, S Tiago, J Cruz Ferreira, R Agapito, A Sequeira, A |
author_role |
author |
author2 |
Aguiar Rosa, S Tiago, J Cruz Ferreira, R Agapito, A Sequeira, A |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Oliveira, D Aguiar Rosa, S Tiago, J Cruz Ferreira, R Agapito, A Sequeira, A |
dc.subject.por.fl_str_mv |
Aorta Aortic Diseases Aortic Valve Case-Control Studies Dilatation, Pathologic Heart Valve Diseases Hemodynamics Humans Models, Cardiovascular Stress, Mechanical Systole HSM CAR |
topic |
Aorta Aortic Diseases Aortic Valve Case-Control Studies Dilatation, Pathologic Heart Valve Diseases Hemodynamics Humans Models, Cardiovascular Stress, Mechanical Systole HSM CAR |
description |
Bicuspid aortic valve (BAV) aortopathy remains of difficult clinical management due to its heterogeneity and further assessment of related aortic hemodynamics is necessary. The aim of this study was to assess systolic hemodynamic indexes and wall stresses in patients with diverse BAV phenotypes and dilated ascending aortas. The aortic geometry was reconstructed from patient-specific images while the aortic valve was generated based on patient-specific measurements. Physiologic material properties and boundary conditions were applied and fully coupled fluid-structure interaction (FSI) analysis were conducted. Our dilated aortic models were characterized by the presence of abnormal hemodynamics with elevated degrees of flow skewness and eccentricity, regardless of BAV morphotype. Retrograde flow was also present. Both features, predicted by flow angle and flow reversal ratios, were consistently higher than those reported for non-dilated aortas. Right-handed helical flow was present, as well as elevated wall shear stress (WSS) on the outer ascending aortic wall. Our results suggest that the abnormal flow associated with BAV may play a role in aortic enlargement and progress it further on already dilated aortas. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-11T11:31:32Z 2019-06 2019-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3325 |
url |
http://hdl.handle.net/10400.17/3325 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Comput Methods Biomech Biomed Engin. 2019 Jun;22(8):815-826. 10.1080/10255842.2019.1597860 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777302274615279616 |