Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Detalhes bibliográficos
Autor(a) principal: Costa, Pedro
Data de Publicação: 2018
Outros Autores: Metello, Luís, Alves, Francisco, Naia, M. Duarte
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14551
Resumo: Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β+ endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging
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spelling Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its ApplicationsCyclotronTitanium-45PETUnconventional radionuclidesPositron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β+ endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imagingRepositório Científico do Instituto Politécnico do PortoCosta, PedroMetello, LuísAlves, FranciscoNaia, M. Duarte2019-08-30T14:35:16Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14551eng10.3390/instruments2020008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:58:13Zoai:recipp.ipp.pt:10400.22/14551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:25.268155Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
title Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
spellingShingle Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
Costa, Pedro
Cyclotron
Titanium-45
PET
Unconventional radionuclides
title_short Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
title_full Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
title_fullStr Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
title_full_unstemmed Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
title_sort Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications
author Costa, Pedro
author_facet Costa, Pedro
Metello, Luís
Alves, Francisco
Naia, M. Duarte
author_role author
author2 Metello, Luís
Alves, Francisco
Naia, M. Duarte
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Costa, Pedro
Metello, Luís
Alves, Francisco
Naia, M. Duarte
dc.subject.por.fl_str_mv Cyclotron
Titanium-45
PET
Unconventional radionuclides
topic Cyclotron
Titanium-45
PET
Unconventional radionuclides
description Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β+ endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-08-30T14:35:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14551
url http://hdl.handle.net/10400.22/14551
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/instruments2020008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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