The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts
Main Author: | |
---|---|
Publication Date: | 2014 |
Format: | Conference object |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.18/2716 |
Summary: | Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The unified model for NMD, proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding protein 1 (PABPC1) and the NMD effector UPF1 for the termination complex. Consequently, PTCs located far, in a linear sense, from the poly(A) tail and associated PABPC1, in mRNAs containing residual downstream exon junction complexes (EJCs), are expected to elicit NMD. Nevertheless, we have reported that human mRNAs containing PTCs in close proximity to the translation initiation codon (AUG-proximal PTCs) can substantially evade NMD through a mechanism independent of translation re-initiation. In this seminar, I will focus on the mechanistic basis for this NMD resistance and how it involves the step of translation initiation. |
id |
RCAP_97952705e5f641145a599b51bb570a7c |
---|---|
oai_identifier_str |
oai:repositorio.insa.pt:10400.18/2716 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcriptsGenómica Funcional e EstruturalNonsense-mediated mRNA Decay (NMDmRNA TranslationNonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The unified model for NMD, proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding protein 1 (PABPC1) and the NMD effector UPF1 for the termination complex. Consequently, PTCs located far, in a linear sense, from the poly(A) tail and associated PABPC1, in mRNAs containing residual downstream exon junction complexes (EJCs), are expected to elicit NMD. Nevertheless, we have reported that human mRNAs containing PTCs in close proximity to the translation initiation codon (AUG-proximal PTCs) can substantially evade NMD through a mechanism independent of translation re-initiation. In this seminar, I will focus on the mechanistic basis for this NMD resistance and how it involves the step of translation initiation.Repositório Científico do Instituto Nacional de SaúdeRomão, Luísa2015-01-30T11:30:19Z2014-07-312014-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://hdl.handle.net/10400.18/2716enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:27Zoai:repositorio.insa.pt:10400.18/2716Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:43.472600Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
title |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
spellingShingle |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts Romão, Luísa Genómica Funcional e Estrutural Nonsense-mediated mRNA Decay (NMD mRNA Translation |
title_short |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
title_full |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
title_fullStr |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
title_full_unstemmed |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
title_sort |
The interplay between mRNA translation and nonsense-mediated decay in AUG-proximal nonsense-mutated transcripts |
author |
Romão, Luísa |
author_facet |
Romão, Luísa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Romão, Luísa |
dc.subject.por.fl_str_mv |
Genómica Funcional e Estrutural Nonsense-mediated mRNA Decay (NMD mRNA Translation |
topic |
Genómica Funcional e Estrutural Nonsense-mediated mRNA Decay (NMD mRNA Translation |
description |
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The unified model for NMD, proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding protein 1 (PABPC1) and the NMD effector UPF1 for the termination complex. Consequently, PTCs located far, in a linear sense, from the poly(A) tail and associated PABPC1, in mRNAs containing residual downstream exon junction complexes (EJCs), are expected to elicit NMD. Nevertheless, we have reported that human mRNAs containing PTCs in close proximity to the translation initiation codon (AUG-proximal PTCs) can substantially evade NMD through a mechanism independent of translation re-initiation. In this seminar, I will focus on the mechanistic basis for this NMD resistance and how it involves the step of translation initiation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07-31 2014-07-31T00:00:00Z 2015-01-30T11:30:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/2716 |
url |
http://hdl.handle.net/10400.18/2716 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132112509468672 |