Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/46293 |
Resumo: | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaborationDMARDs (biologic)Outcomes researchSpondyloarthritis© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Objectives: To explore 6-month and 12-month secukinumab effectiveness in patients with axial spondyloarthritis (axSpA) overall, as well as across (1) number of previous biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), (2) time since diagnosis and (3) different European registries. Methods: Real-life data from 13 European registries participating in the European Spondyloarthritis Research Collaboration Network were pooled. Kaplan-Meier with log-rank test, Cox regression, χ² and logistic regression analyses were performed to assess 6-month and 12-month secukinumab retention, inactive disease/low-disease-activity states (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) <2/<4, Ankylosing Spondylitis Disease Activity Score (ASDAS) <1.3/<2.1) and response rates (BASDAI50, Assessment of Spondyloarthritis International Society (ASAS) 20/40, ASDAS clinically important improvement (ASDAS-CII) and ASDAS major improvement (ASDAS-MI)). Results: We included 1860 patients initiating secukinumab as part of routine care. Overall 6-month/12-month secukinumab retention rates were 82%/72%, with significant (p<0.001) differences between the registries (6-month: 70-93%, 12-month: 53-86%) and across number of previous b/tsDMARDs (b/tsDMARD-naïve: 90%/73%, 1 prior b/tsDMARD: 83%/73%, ≥2 prior b/tsDMARDs: 78%/66%). Overall 6-month/12-month BASDAI<4 were observed in 51%/51%, ASDAS<1.3 in 9%/11%, BASDAI50 in 53%/47%, ASAS40 in 28%/22%, ASDAS-CII in 49%/46% and ASDAS-MI in 25%/26% of the patients. All rates differed significantly across number of previous b/tsDMARDs, were numerically higher for b/tsDMARD-naïve patients and varied significantly across registries. Overall, time since diagnosis was not associated with secukinumab effectiveness. Conclusions: In this study of 1860 patients from 13 European countries, we present the first comprehensive real-life data on effectiveness of secukinumab in patients with axSpA. Overall, secukinumab retention rates after 6 and 12 months of treatment were high. Secukinumab effectiveness was consistently better for bionaïve patients, independent of time since diagnosis and differed across the European countries.BMJ Publishing Group LtdRepositório da Universidade de LisboaMichelsen, BrigitteLindström, UlfCodreanu, CatalinCiurea, AdrianZavada, JakubLoft, Anne GittePombo-Suarez, ManuelOnen, FatosKvien, Tore K.Rotar, ZigaSantos, MariaIannone, FlorenzoHokkanen, Anna-MariGudbjornsson, BjornAskling, JohanIonescu, RuxandraNissen, Michael J.Pavelka, KarelSanchez-Piedra, CarlosAkar, ServetSexton, JosephTomsic, MatijaSantos, HelenaSebastiani, MarcoÖsterlund, JennyGeirsson, Arni JonMacfarlane, Garyvan der Horst-Bruinsma, IreneGeorgiadis, StylianosBrahe, Cecilie HeegaardØrnbjerg, Lykke MidtbøllHetland, Merete LundØstergaard, Mikkel2021-02-11T16:34:59Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46293engRMD Open. 2020 Sep;6(3):e00128010.1136/rmdopen-2020-0012802056-5933info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:32Zoai:repositorio.ul.pt:10451/46293Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:31.785987Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| title |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| spellingShingle |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration Michelsen, Brigitte DMARDs (biologic) Outcomes research Spondyloarthritis |
| title_short |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| title_full |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| title_fullStr |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| title_full_unstemmed |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| title_sort |
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration |
| author |
Michelsen, Brigitte |
| author_facet |
Michelsen, Brigitte Lindström, Ulf Codreanu, Catalin Ciurea, Adrian Zavada, Jakub Loft, Anne Gitte Pombo-Suarez, Manuel Onen, Fatos Kvien, Tore K. Rotar, Ziga Santos, Maria Iannone, Florenzo Hokkanen, Anna-Mari Gudbjornsson, Bjorn Askling, Johan Ionescu, Ruxandra Nissen, Michael J. Pavelka, Karel Sanchez-Piedra, Carlos Akar, Servet Sexton, Joseph Tomsic, Matija Santos, Helena Sebastiani, Marco Österlund, Jenny Geirsson, Arni Jon Macfarlane, Gary van der Horst-Bruinsma, Irene Georgiadis, Stylianos Brahe, Cecilie Heegaard Ørnbjerg, Lykke Midtbøll Hetland, Merete Lund Østergaard, Mikkel |
| author_role |
author |
| author2 |
Lindström, Ulf Codreanu, Catalin Ciurea, Adrian Zavada, Jakub Loft, Anne Gitte Pombo-Suarez, Manuel Onen, Fatos Kvien, Tore K. Rotar, Ziga Santos, Maria Iannone, Florenzo Hokkanen, Anna-Mari Gudbjornsson, Bjorn Askling, Johan Ionescu, Ruxandra Nissen, Michael J. Pavelka, Karel Sanchez-Piedra, Carlos Akar, Servet Sexton, Joseph Tomsic, Matija Santos, Helena Sebastiani, Marco Österlund, Jenny Geirsson, Arni Jon Macfarlane, Gary van der Horst-Bruinsma, Irene Georgiadis, Stylianos Brahe, Cecilie Heegaard Ørnbjerg, Lykke Midtbøll Hetland, Merete Lund Østergaard, Mikkel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Michelsen, Brigitte Lindström, Ulf Codreanu, Catalin Ciurea, Adrian Zavada, Jakub Loft, Anne Gitte Pombo-Suarez, Manuel Onen, Fatos Kvien, Tore K. Rotar, Ziga Santos, Maria Iannone, Florenzo Hokkanen, Anna-Mari Gudbjornsson, Bjorn Askling, Johan Ionescu, Ruxandra Nissen, Michael J. Pavelka, Karel Sanchez-Piedra, Carlos Akar, Servet Sexton, Joseph Tomsic, Matija Santos, Helena Sebastiani, Marco Österlund, Jenny Geirsson, Arni Jon Macfarlane, Gary van der Horst-Bruinsma, Irene Georgiadis, Stylianos Brahe, Cecilie Heegaard Ørnbjerg, Lykke Midtbøll Hetland, Merete Lund Østergaard, Mikkel |
| dc.subject.por.fl_str_mv |
DMARDs (biologic) Outcomes research Spondyloarthritis |
| topic |
DMARDs (biologic) Outcomes research Spondyloarthritis |
| description |
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-02-11T16:34:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/46293 |
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http://hdl.handle.net/10451/46293 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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RMD Open. 2020 Sep;6(3):e001280 10.1136/rmdopen-2020-001280 2056-5933 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group Ltd |
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BMJ Publishing Group Ltd |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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