Cellular and Molecular Toxicity of Iron Oxide Nanoparticles

Detalhes bibliográficos
Autor(a) principal: Laffon, Blanca
Data de Publicação: 2018
Outros Autores: Fernández-Bertólez, Natalia, Costa, Carla, Brandão, Fátima, Teixeira, João Paulo, Pásaro, Eduardo, Valdiglesias, Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6301
Resumo: Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042468/
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spelling Cellular and Molecular Toxicity of Iron Oxide NanoparticlesIron oxide nanoparticlesCell CycleCell DeathCell MembraneCell MovementCell SurvivalContrast MediaDrug Delivery SystemsHumansMagnetite NanoparticlesAnimalsGenotoxicidade AmbientalFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042468/Iron oxide nanoparticles (ION) have attracted much attention because of their particular physico-chemical properties, including superparamagnetism. These features make them suitable for many purposes and several interesting biomedical applications, such as to increase contrast in magnetic resonance imaging (MRI), as drug delivery systems and as hyperthermia agents. However, they have also shown to be easily accumulated in diverse tissues and induce toxicity at different levels. This chapter reviews the different cellular and molecular effects induced by ION reported from in vitro studies with human and non-human cell lines. Those effects are mainly dependent on ION type and concentration, time of exposure, presence and nature of coating, and cell type evaluated. They include decreases in viability, plasmatic membrane disruption, oxidative damage, mitochondrial alterations, cell cycle impairments, cytoskeleton disruption, cell death, and alterations in cell motility, and in cell integrity. Despite these negative effects, the numerous advantages of ION together with their promising applications in biomedicine, make it necessary to clearly define their toxicity in order to discard potential health risks and to reach optimal benefits of their use.This work was supported by Xunta de Galicia (grant number ED431B 2016/013) and the projects NanoToxClass (ERA-SIINN/001/2013) funded by FCT/MCTES (PIDDAC) and co-funded by the European Regional Development Fund (ERDF) through the COMPETE Programme, and CERASAFE (SIINN/0004/2014) funded by FCT (national funds of MES) and co-funded by the European Union (ERA-NET SIINN programme). V. Valdiglesias was supported by a Xunta de Galicia postdoctoral fellowship (reference ED481B 2016/190-0). N. Fernández-Bertólez was supported by an INDITEX-UDC fellowship. F. Brandão was supported by the grant SFRH/BD/101060/2014, funded by FCT (financing subsided by national fund of MES).SpringerRepositório Científico do Instituto Nacional de SaúdeLaffon, BlancaFernández-Bertólez, NataliaCosta, CarlaBrandão, FátimaTeixeira, João PauloPásaro, EduardoValdiglesias, Vanessa2019-03-25T16:58:13Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6301engAdv Exp Med Biol. 2018;1048:199-213. doi: 10.1007/978-3-319-72041-8_120065-259810.1007/978-3-319-72041-8_12info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:19Zoai:repositorio.insa.pt:10400.18/6301Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:55.195953Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
title Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
spellingShingle Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
Laffon, Blanca
Iron oxide nanoparticles
Cell Cycle
Cell Death
Cell Membrane
Cell Movement
Cell Survival
Contrast Media
Drug Delivery Systems
Humans
Magnetite Nanoparticles
Animals
Genotoxicidade Ambiental
title_short Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
title_full Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
title_fullStr Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
title_full_unstemmed Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
title_sort Cellular and Molecular Toxicity of Iron Oxide Nanoparticles
author Laffon, Blanca
author_facet Laffon, Blanca
Fernández-Bertólez, Natalia
Costa, Carla
Brandão, Fátima
Teixeira, João Paulo
Pásaro, Eduardo
Valdiglesias, Vanessa
author_role author
author2 Fernández-Bertólez, Natalia
Costa, Carla
Brandão, Fátima
Teixeira, João Paulo
Pásaro, Eduardo
Valdiglesias, Vanessa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Laffon, Blanca
Fernández-Bertólez, Natalia
Costa, Carla
Brandão, Fátima
Teixeira, João Paulo
Pásaro, Eduardo
Valdiglesias, Vanessa
dc.subject.por.fl_str_mv Iron oxide nanoparticles
Cell Cycle
Cell Death
Cell Membrane
Cell Movement
Cell Survival
Contrast Media
Drug Delivery Systems
Humans
Magnetite Nanoparticles
Animals
Genotoxicidade Ambiental
topic Iron oxide nanoparticles
Cell Cycle
Cell Death
Cell Membrane
Cell Movement
Cell Survival
Contrast Media
Drug Delivery Systems
Humans
Magnetite Nanoparticles
Animals
Genotoxicidade Ambiental
description Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042468/
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-03-25T16:58:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6301
url http://hdl.handle.net/10400.18/6301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Adv Exp Med Biol. 2018;1048:199-213. doi: 10.1007/978-3-319-72041-8_12
0065-2598
10.1007/978-3-319-72041-8_12
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
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dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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