The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/152474 |
Resumo: | Posttraumatic stress disorder (PTSD) has been associated with glucocorticoid (GC) hyper-sensitivity. Although genetic factors account for 30–46% of the variance in PTSD, no associations have been found between single nucleotide polymorphisms (SNPs) of the GC receptor (GR) gene (NR3C1) and risk for this disorder. We studied the association of five SNPs in the GR gene (rs10052957, rs6189/rs6190, rs6195, rs41423247, and rs6198) and haplotypes with PTSD, in a group of Portuguese male war veterans (33 with lifetime PTSD, 28 without). To determine whether the 9ß SNP (rs6198) was associated with chronically altered cortisol levels, we evaluated hair cortisol concentrations (HCC) in a sample of 69 veterans’ offspring. The 9ß variant (G allele) was significantly associated with lifetime PTSD under a dominant model of inheritance. The 9ß variant was also significantly associated with severity of current PTSD symptoms. The haplotype analysis revealed an association between a common haplotype comprising the 9ß risk allele and lifetime PTSD. Carriers of the 9ß risk allele had significantly lower HCC than non-carriers. We found the 9ß risk allele and a haplotype comprising the 9ß risk allele of the GR gene to be associated with PTSD in veterans. This 9ß risk allele was also associated with lower HCC in their offspring. |
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The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorderGeneticsGlucocorticoid receptorHair cortisolNR3C1Posttraumatic stress disorderSingle nucleotide polymorphismWar veteransPosttraumatic stress disorder (PTSD) has been associated with glucocorticoid (GC) hyper-sensitivity. Although genetic factors account for 30–46% of the variance in PTSD, no associations have been found between single nucleotide polymorphisms (SNPs) of the GC receptor (GR) gene (NR3C1) and risk for this disorder. We studied the association of five SNPs in the GR gene (rs10052957, rs6189/rs6190, rs6195, rs41423247, and rs6198) and haplotypes with PTSD, in a group of Portuguese male war veterans (33 with lifetime PTSD, 28 without). To determine whether the 9ß SNP (rs6198) was associated with chronically altered cortisol levels, we evaluated hair cortisol concentrations (HCC) in a sample of 69 veterans’ offspring. The 9ß variant (G allele) was significantly associated with lifetime PTSD under a dominant model of inheritance. The 9ß variant was also significantly associated with severity of current PTSD symptoms. The haplotype analysis revealed an association between a common haplotype comprising the 9ß risk allele and lifetime PTSD. Carriers of the 9ß risk allele had significantly lower HCC than non-carriers. We found the 9ß risk allele and a haplotype comprising the 9ß risk allele of the GR gene to be associated with PTSD in veterans. This 9ß risk allele was also associated with lower HCC in their offspring.MDPI20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152474eng2227-903210.3390/healthcare9020173Castro-Vale, IDurães, Cvan Rossum, EFCStaufenbiel, SMSevero, MLemos, MCCarvalho, Dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:24:53Zoai:repositorio-aberto.up.pt:10216/152474Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:23:06.196439Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
title |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
spellingShingle |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder Castro-Vale, I Genetics Glucocorticoid receptor Hair cortisol NR3C1 Posttraumatic stress disorder Single nucleotide polymorphism War veterans |
title_short |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
title_full |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
title_fullStr |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
title_full_unstemmed |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
title_sort |
The glucocorticoid receptor gene (Nr3c1) 9ß snp is associated with posttraumatic stress disorder |
author |
Castro-Vale, I |
author_facet |
Castro-Vale, I Durães, C van Rossum, EFC Staufenbiel, SM Severo, M Lemos, MC Carvalho, D |
author_role |
author |
author2 |
Durães, C van Rossum, EFC Staufenbiel, SM Severo, M Lemos, MC Carvalho, D |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Castro-Vale, I Durães, C van Rossum, EFC Staufenbiel, SM Severo, M Lemos, MC Carvalho, D |
dc.subject.por.fl_str_mv |
Genetics Glucocorticoid receptor Hair cortisol NR3C1 Posttraumatic stress disorder Single nucleotide polymorphism War veterans |
topic |
Genetics Glucocorticoid receptor Hair cortisol NR3C1 Posttraumatic stress disorder Single nucleotide polymorphism War veterans |
description |
Posttraumatic stress disorder (PTSD) has been associated with glucocorticoid (GC) hyper-sensitivity. Although genetic factors account for 30–46% of the variance in PTSD, no associations have been found between single nucleotide polymorphisms (SNPs) of the GC receptor (GR) gene (NR3C1) and risk for this disorder. We studied the association of five SNPs in the GR gene (rs10052957, rs6189/rs6190, rs6195, rs41423247, and rs6198) and haplotypes with PTSD, in a group of Portuguese male war veterans (33 with lifetime PTSD, 28 without). To determine whether the 9ß SNP (rs6198) was associated with chronically altered cortisol levels, we evaluated hair cortisol concentrations (HCC) in a sample of 69 veterans’ offspring. The 9ß variant (G allele) was significantly associated with lifetime PTSD under a dominant model of inheritance. The 9ß variant was also significantly associated with severity of current PTSD symptoms. The haplotype analysis revealed an association between a common haplotype comprising the 9ß risk allele and lifetime PTSD. Carriers of the 9ß risk allele had significantly lower HCC than non-carriers. We found the 9ß risk allele and a haplotype comprising the 9ß risk allele of the GR gene to be associated with PTSD in veterans. This 9ß risk allele was also associated with lower HCC in their offspring. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/152474 |
url |
https://hdl.handle.net/10216/152474 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2227-9032 10.3390/healthcare9020173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136146851102720 |