CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS

Detalhes bibliográficos
Autor(a) principal: Pedrosa, Ana
Data de Publicação: 2015
Outros Autores: Lopes, José Manuel, Azevedo, Filomena
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.72.4.318
Resumo: Background: Lupus Erythematosus (LE) represents a multiorganic, autoimmune disease that affects mainly women of child-bearing age. The skin is the second most frequently affected organ, after the joints, and may precede the clinical onset of systemic symptoms.Objectives: To present the clinical findings which evoke the possibility of LE-specific skin lesions and the histopathological findings that may co-substantiate the diagnosis.Methods: Case studies of LE-specific skin lesions, in which the clinical-pathological correlation enabled the diagnosis of different subtypes of LE.Results: The correlation of clinical and histopathological findings, in a consistent serological setting, enabled the recognition of actual cases of LE-specific skin lesions: 1) acute; 2) subacute (annular and papulosquamous forms); 2.1) drug-induced subacute LE; 3) chronic, namely 3.1) classic discoid (face and scalp); 3.2) tumidus; 3.3) panniculitis.Moreover, the clinical and histopathological findings expected in other LE-specific skin lesions are described.Conclusions: Lupus Erythematosus exhibits a variability of cutaneous manifestations. The histopathology is critical for the diagnosis requiring a correct preservation and handling of biopsy material. Direct immunofluorescence remains useful to improve the diagnostic specificity. The accurate diagnosis, based in a systematic clinical-pathological correlation and integrated with the clinical and serological status, is crucial for the prognosis and treatment of the patients.
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spelling CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONSLÚPUS ERITEMATOSO CUTÂNEO - CORRELAÇÃO CLÍNICOPATOLÓGICA DE MANIFESTAÇÕES CUTÂNEAS ESPECÍFICASLupus erythematosuscutaneousLúpus eritematoso cutâneoBackground: Lupus Erythematosus (LE) represents a multiorganic, autoimmune disease that affects mainly women of child-bearing age. The skin is the second most frequently affected organ, after the joints, and may precede the clinical onset of systemic symptoms.Objectives: To present the clinical findings which evoke the possibility of LE-specific skin lesions and the histopathological findings that may co-substantiate the diagnosis.Methods: Case studies of LE-specific skin lesions, in which the clinical-pathological correlation enabled the diagnosis of different subtypes of LE.Results: The correlation of clinical and histopathological findings, in a consistent serological setting, enabled the recognition of actual cases of LE-specific skin lesions: 1) acute; 2) subacute (annular and papulosquamous forms); 2.1) drug-induced subacute LE; 3) chronic, namely 3.1) classic discoid (face and scalp); 3.2) tumidus; 3.3) panniculitis.Moreover, the clinical and histopathological findings expected in other LE-specific skin lesions are described.Conclusions: Lupus Erythematosus exhibits a variability of cutaneous manifestations. The histopathology is critical for the diagnosis requiring a correct preservation and handling of biopsy material. Direct immunofluorescence remains useful to improve the diagnostic specificity. The accurate diagnosis, based in a systematic clinical-pathological correlation and integrated with the clinical and serological status, is crucial for the prognosis and treatment of the patients.Introdução: O lúpus eritematoso (LE) é uma patologia multiorgânica autoimune que afeta sobretudo mulheres em idade fértil. A pele é o segundo órgão mais frequentemente atingido, depois das articulações, e pode preceder o envolvimento sistémico.Objetivos: Apresentar aspetos clínicos que evocam a hipótese de manifestações cutâneas específicas de LE e achados histopatológicos que podem contribuir para fundamentar o diagnóstico.Métodos: Estudo de casos com manifestações cutâneas sugestivas de LE, nos quais a correlação clínico-histopatológica possibilitou o diagnóstico de diferentes subtipos de LE.Resultados: A correlação das alterações clínicas e histopatológicas, no contexto analítico apropriado, permitiu identificar casos concretos de manifestações cutâneas específicas de LE: 1) agudo; 2) subagudo (formas anular e papular-escamosa); 2.1) subagudo induzido por fármacos; 3) crónico, nomeadamente 3.1) discóide clássico (face e couro cabeludo); 3.2) túmido; 3.3) paniculite.Descreve-se, adicionalmente, os achados clínicos e histopatológicos expectáveis em outras manifestações cutâneas específicas de LE.Conclusão: O LE exibe grande variabilidade de manifestações cutâneas. A histopatologia é essencial para o diagnóstico, sendo muito importante a preservação e manuseamento apropriado do material de biópsia. A imunofluorescência direta é útil para melhorar a acuidade diagnóstica. O diagnóstico preciso, baseado na correlação clínico-patológica sistemática e integrado no contexto clínico-analítico adequado, é fundamental para o prognóstico e orientação terapêutica dos doentes.Sociedade Portuguesa de Dermatologia e Venereologia2015-04-13T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.72.4.318oai:ojs.revista.spdv.com.pt:article/318Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 493-503Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 493-5032182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/318https://doi.org/10.29021/spdv.72.4.318https://revista.spdv.com.pt/index.php/spdv/article/view/318/292Pedrosa, AnaLopes, José ManuelAzevedo, Filomenainfo:eu-repo/semantics/openAccess2022-10-06T12:34:50Zoai:ojs.revista.spdv.com.pt:article/318Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:50.121731Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
LÚPUS ERITEMATOSO CUTÂNEO - CORRELAÇÃO CLÍNICOPATOLÓGICA DE MANIFESTAÇÕES CUTÂNEAS ESPECÍFICAS
title CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
spellingShingle CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
Pedrosa, Ana
Lupus erythematosus
cutaneous
Lúpus eritematoso cutâneo
title_short CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
title_full CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
title_fullStr CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
title_full_unstemmed CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
title_sort CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECIFIC SKIN LESIONS
author Pedrosa, Ana
author_facet Pedrosa, Ana
Lopes, José Manuel
Azevedo, Filomena
author_role author
author2 Lopes, José Manuel
Azevedo, Filomena
author2_role author
author
dc.contributor.author.fl_str_mv Pedrosa, Ana
Lopes, José Manuel
Azevedo, Filomena
dc.subject.por.fl_str_mv Lupus erythematosus
cutaneous
Lúpus eritematoso cutâneo
topic Lupus erythematosus
cutaneous
Lúpus eritematoso cutâneo
description Background: Lupus Erythematosus (LE) represents a multiorganic, autoimmune disease that affects mainly women of child-bearing age. The skin is the second most frequently affected organ, after the joints, and may precede the clinical onset of systemic symptoms.Objectives: To present the clinical findings which evoke the possibility of LE-specific skin lesions and the histopathological findings that may co-substantiate the diagnosis.Methods: Case studies of LE-specific skin lesions, in which the clinical-pathological correlation enabled the diagnosis of different subtypes of LE.Results: The correlation of clinical and histopathological findings, in a consistent serological setting, enabled the recognition of actual cases of LE-specific skin lesions: 1) acute; 2) subacute (annular and papulosquamous forms); 2.1) drug-induced subacute LE; 3) chronic, namely 3.1) classic discoid (face and scalp); 3.2) tumidus; 3.3) panniculitis.Moreover, the clinical and histopathological findings expected in other LE-specific skin lesions are described.Conclusions: Lupus Erythematosus exhibits a variability of cutaneous manifestations. The histopathology is critical for the diagnosis requiring a correct preservation and handling of biopsy material. Direct immunofluorescence remains useful to improve the diagnostic specificity. The accurate diagnosis, based in a systematic clinical-pathological correlation and integrated with the clinical and serological status, is crucial for the prognosis and treatment of the patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-13T00:00:00Z
dc.type.driver.fl_str_mv journal article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.72.4.318
oai:ojs.revista.spdv.com.pt:article/318
url https://doi.org/10.29021/spdv.72.4.318
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/318
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/318
https://doi.org/10.29021/spdv.72.4.318
https://revista.spdv.com.pt/index.php/spdv/article/view/318/292
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 493-503
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 493-503
2182-2409
2182-2395
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