Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/90486 https://doi.org/10.3390/ijms21072262 |
Resumo: | The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies. |
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Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Aheadretinal ganglion cellsneurodegenerationaxonal regenerationneuroprotectionoptic neuropathiesThe retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies.This work was supported by Foundation for Science and Technology (FCT), Portugal (Fellowships PD/BD/114115/2015 and PD/BD/127821/2016, Grant PTDC/NEU-OSD/3123/2014 and Strategic Projects UID/NEU/04539/2013, UID/NEU/04539/2019, UIDP/04539/2020 and UIDB/04539/2020), FEDER-COMPETE POCI-01-0145-FEDER-016849, FCOMP-01-0124-FEDER-028417, POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BrainHealth 2020). Grupos UPV/EHU GIU18/50, PUE 2018-04 and ELKARTEK KK-2019/00086 to E.V.MDPI2020-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/90486http://hdl.handle.net/10316/90486https://doi.org/10.3390/ijms21072262eng1422-0067Boia, RaquelRuzafa, NoeliaAires, Inês DinisPereiro, XandraAmbrósio, António FranciscoVecino, ElenaSantiago, Ana Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:58:48Zoai:estudogeral.uc.pt:10316/90486Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:10:36.737627Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
title |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
spellingShingle |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead Boia, Raquel retinal ganglion cells neurodegeneration axonal regeneration neuroprotection optic neuropathies |
title_short |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
title_full |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
title_fullStr |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
title_full_unstemmed |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
title_sort |
Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead |
author |
Boia, Raquel |
author_facet |
Boia, Raquel Ruzafa, Noelia Aires, Inês Dinis Pereiro, Xandra Ambrósio, António Francisco Vecino, Elena Santiago, Ana Raquel |
author_role |
author |
author2 |
Ruzafa, Noelia Aires, Inês Dinis Pereiro, Xandra Ambrósio, António Francisco Vecino, Elena Santiago, Ana Raquel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Boia, Raquel Ruzafa, Noelia Aires, Inês Dinis Pereiro, Xandra Ambrósio, António Francisco Vecino, Elena Santiago, Ana Raquel |
dc.subject.por.fl_str_mv |
retinal ganglion cells neurodegeneration axonal regeneration neuroprotection optic neuropathies |
topic |
retinal ganglion cells neurodegeneration axonal regeneration neuroprotection optic neuropathies |
description |
The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/90486 http://hdl.handle.net/10316/90486 https://doi.org/10.3390/ijms21072262 |
url |
http://hdl.handle.net/10316/90486 https://doi.org/10.3390/ijms21072262 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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1422-0067 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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