Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil

Detalhes bibliográficos
Autor(a) principal: dos Santos, Danielle Talita
Data de Publicação: 2021
Outros Autores: Arroyo, Luiz Henrique, Alves, Yan Mathias, Alves, Luana Seles, Berra, Thais Zamboni, Crispim, Juliane de Almeida, Alves, Josilene Dália, Ramos, Denisse Andrea Cartagena, Alonso, Jonas Bodini, de Assis, Ivaneliza Simionato, Ramos, Antônio Vieira, Dessunti, Elma Mathias, Carvalho Pinto, Ione, Palha, Pedro Fredemir, Arcêncio, Ricardo Alexandre, Nunes, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/117339
Resumo: Background: A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and associated factors in southern Brazil. Methods: We conducted a longitudinal study with patients who were diagnosed with TB and who died due to the disease between 2008 and 2015 in southern Brazil. The starting point for measuring survival time was the patient’s diagnosis date. Techniques for survival analysis were employed, including the Kaplan-Meier test and Cox’s regression. A mixed-effect model was applied for identifying the associated factors to precocious deaths. Hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (95% CI) were estimated. We defined p value <0.05 as statistically significant for all statistics applied. Results: One hundred forty-six patients were included in the survival analysis, observing a median survival time of 23.5 days. We observed that alcoholism (HR=1.55, 95% CI=1.04-2.30) and being male (HR=6.49, 95% CI=1.03-2.68) were associated with death. The chance of precocious death within 60 days was 10.48 times greater than the chance of early death within 30 days. Conclusion: Most of the deaths occurred within 2 months after the diagnosis, during the intensive phase of the treatment. The use of alcohol and gender were associated with death, revealing inequality between men and women. This study advanced knowledge regarding the vulnerability associated with mortality. These findings must be addressed to fill a gap in the care cascades for active TB and ensure equity in health.
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spelling Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern BrazilHIVMortalityRisk factorsSurvival analysisTuberculosisPublic Health, Environmental and Occupational HealthInfectious DiseasesSDG 3 - Good Health and Well-beingBackground: A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and associated factors in southern Brazil. Methods: We conducted a longitudinal study with patients who were diagnosed with TB and who died due to the disease between 2008 and 2015 in southern Brazil. The starting point for measuring survival time was the patient’s diagnosis date. Techniques for survival analysis were employed, including the Kaplan-Meier test and Cox’s regression. A mixed-effect model was applied for identifying the associated factors to precocious deaths. Hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (95% CI) were estimated. We defined p value <0.05 as statistically significant for all statistics applied. Results: One hundred forty-six patients were included in the survival analysis, observing a median survival time of 23.5 days. We observed that alcoholism (HR=1.55, 95% CI=1.04-2.30) and being male (HR=6.49, 95% CI=1.03-2.68) were associated with death. The chance of precocious death within 60 days was 10.48 times greater than the chance of early death within 30 days. Conclusion: Most of the deaths occurred within 2 months after the diagnosis, during the intensive phase of the treatment. The use of alcohol and gender were associated with death, revealing inequality between men and women. This study advanced knowledge regarding the vulnerability associated with mortality. These findings must be addressed to fill a gap in the care cascades for active TB and ensure equity in health.Escola Nacional de Saúde Pública (ENSP)RUNdos Santos, Danielle TalitaArroyo, Luiz HenriqueAlves, Yan MathiasAlves, Luana SelesBerra, Thais ZamboniCrispim, Juliane de AlmeidaAlves, Josilene DáliaRamos, Denisse Andrea CartagenaAlonso, Jonas Bodinide Assis, Ivaneliza SimionatoRamos, Antônio VieiraDessunti, Elma MathiasCarvalho Pinto, IonePalha, Pedro FredemirArcêncio, Ricardo AlexandreNunes, Carla2021-05-07T23:07:30Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117339eng1348-8945PURE: 29611486https://doi.org/10.1186/s41182-021-00320-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:00:29Zoai:run.unl.pt:10362/117339Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:36.116661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
title Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
spellingShingle Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
dos Santos, Danielle Talita
HIV
Mortality
Risk factors
Survival analysis
Tuberculosis
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
title_full Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
title_fullStr Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
title_full_unstemmed Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
title_sort Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
author dos Santos, Danielle Talita
author_facet dos Santos, Danielle Talita
Arroyo, Luiz Henrique
Alves, Yan Mathias
Alves, Luana Seles
Berra, Thais Zamboni
Crispim, Juliane de Almeida
Alves, Josilene Dália
Ramos, Denisse Andrea Cartagena
Alonso, Jonas Bodini
de Assis, Ivaneliza Simionato
Ramos, Antônio Vieira
Dessunti, Elma Mathias
Carvalho Pinto, Ione
Palha, Pedro Fredemir
Arcêncio, Ricardo Alexandre
Nunes, Carla
author_role author
author2 Arroyo, Luiz Henrique
Alves, Yan Mathias
Alves, Luana Seles
Berra, Thais Zamboni
Crispim, Juliane de Almeida
Alves, Josilene Dália
Ramos, Denisse Andrea Cartagena
Alonso, Jonas Bodini
de Assis, Ivaneliza Simionato
Ramos, Antônio Vieira
Dessunti, Elma Mathias
Carvalho Pinto, Ione
Palha, Pedro Fredemir
Arcêncio, Ricardo Alexandre
Nunes, Carla
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv dos Santos, Danielle Talita
Arroyo, Luiz Henrique
Alves, Yan Mathias
Alves, Luana Seles
Berra, Thais Zamboni
Crispim, Juliane de Almeida
Alves, Josilene Dália
Ramos, Denisse Andrea Cartagena
Alonso, Jonas Bodini
de Assis, Ivaneliza Simionato
Ramos, Antônio Vieira
Dessunti, Elma Mathias
Carvalho Pinto, Ione
Palha, Pedro Fredemir
Arcêncio, Ricardo Alexandre
Nunes, Carla
dc.subject.por.fl_str_mv HIV
Mortality
Risk factors
Survival analysis
Tuberculosis
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
topic HIV
Mortality
Risk factors
Survival analysis
Tuberculosis
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
description Background: A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and associated factors in southern Brazil. Methods: We conducted a longitudinal study with patients who were diagnosed with TB and who died due to the disease between 2008 and 2015 in southern Brazil. The starting point for measuring survival time was the patient’s diagnosis date. Techniques for survival analysis were employed, including the Kaplan-Meier test and Cox’s regression. A mixed-effect model was applied for identifying the associated factors to precocious deaths. Hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (95% CI) were estimated. We defined p value <0.05 as statistically significant for all statistics applied. Results: One hundred forty-six patients were included in the survival analysis, observing a median survival time of 23.5 days. We observed that alcoholism (HR=1.55, 95% CI=1.04-2.30) and being male (HR=6.49, 95% CI=1.03-2.68) were associated with death. The chance of precocious death within 60 days was 10.48 times greater than the chance of early death within 30 days. Conclusion: Most of the deaths occurred within 2 months after the diagnosis, during the intensive phase of the treatment. The use of alcohol and gender were associated with death, revealing inequality between men and women. This study advanced knowledge regarding the vulnerability associated with mortality. These findings must be addressed to fill a gap in the care cascades for active TB and ensure equity in health.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-07T23:07:30Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
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PURE: 29611486
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