Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

Detalhes bibliográficos
Autor(a) principal: Nosrati, Hamed
Data de Publicação: 2022
Outros Autores: Ghaffarlou, Mohammadreza, Salehiabar, Marziyeh, Mousazadeh, Navid, Abhari, Fatemeh, Barsbay, Murat, Ertas, Yavuz Nuri, Rashidzadeh, Hamid, Mohammadi, Ali, Nasehi, Leila, Rezaeejam, Hamed, Davaran, Soodabeh, Ramazani, Ali, Conde, João, Danafar, Hossein
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154203
Resumo: Funding Information: This work supported by the “ Iran National Science Foundation : INSF-98024375 ”, Iran's National Elites Foundation , and the “ University of Zanjan ”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325 . Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346 ). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192 ). Funding Information: This work supported by the “Iran National Science Foundation: INSF-98024375”, Iran's National Elites Foundation, and the “University of Zanjan”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325. Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192). Publisher Copyright: © 2022
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spelling Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancerBismuth sulfideIron oxideJanus nanoparticlesRadiosensitizerROS generationX-ray irradiationBiomedical EngineeringBiomaterialsBioengineeringSDG 3 - Good Health and Well-beingFunding Information: This work supported by the “ Iran National Science Foundation : INSF-98024375 ”, Iran's National Elites Foundation , and the “ University of Zanjan ”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325 . Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346 ). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192 ). Funding Information: This work supported by the “Iran National Science Foundation: INSF-98024375”, Iran's National Elites Foundation, and the “University of Zanjan”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325. Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192). Publisher Copyright: © 2022Janus heterostructures based on bimetallic nanoparticles have emerged as effective radiosensitizers owing to their radiosensitization capabilities in cancer cells. In this context, this study aims at developing a novel bimetallic nanoradiosensitizer, Bi2S3-Fe3O4, to enhance tumor accumulation and promote radiation-induced DNA damage while reducing adverse effects. Due to the presence of both iron oxide and bismuth sulfide metallic nanoparticles in these newly developed nanoparticle, strong radiosensitizing capacity is anticipated through the generation of reactive oxygen species (ROS) to induce DNA damage under X-Ray irradiation. To improve blood circulation time, biocompatibility, colloidal stability, and tuning surface functionalization, the surface of Bi2S3-Fe3O4 bimetallic nanoparticles was coated with bovine serum albumin (BSA). Moreover, to achieve higher cellular uptake and efficient tumor site specificity, folic acid (FA) as a targeting moiety was conjugated onto the bimetallic nanoparticles, termed Bi2S3@BSA-Fe3O4-FA. Biocompatibility, safety, radiation-induced DNA damage by ROS activation and generation, and radiosensitizing ability were confirmed via in vitro and in vivo assays. The administration of Bi2S3@BSA-Fe3O4-FA in 4T1 breast cancer murine model upon X-ray radiation revealed highly effective tumor eradication without causing any mortality or severe toxicity in healthy tissues. These findings offer compelling evidence for the potential capability of Bi2S3@BSA-Fe3O4-FA as an ideal nanoparticle for radiation-induced cancer therapy and open interesting avenues of future research in this area.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNNosrati, HamedGhaffarlou, MohammadrezaSalehiabar, MarziyehMousazadeh, NavidAbhari, FatemehBarsbay, MuratErtas, Yavuz NuriRashidzadeh, HamidMohammadi, AliNasehi, LeilaRezaeejam, HamedDavaran, SoodabehRamazani, AliConde, JoãoDanafar, Hossein2023-06-20T22:20:03Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/154203eng2772-9508PURE: 46373680https://doi.org/10.1016/j.bioadv.2022.213090info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:39Zoai:run.unl.pt:10362/154203Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:31.790126Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
title Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
spellingShingle Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
Nosrati, Hamed
Bismuth sulfide
Iron oxide
Janus nanoparticles
Radiosensitizer
ROS generation
X-ray irradiation
Biomedical Engineering
Biomaterials
Bioengineering
SDG 3 - Good Health and Well-being
title_short Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
title_full Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
title_fullStr Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
title_full_unstemmed Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
title_sort Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer
author Nosrati, Hamed
author_facet Nosrati, Hamed
Ghaffarlou, Mohammadreza
Salehiabar, Marziyeh
Mousazadeh, Navid
Abhari, Fatemeh
Barsbay, Murat
Ertas, Yavuz Nuri
Rashidzadeh, Hamid
Mohammadi, Ali
Nasehi, Leila
Rezaeejam, Hamed
Davaran, Soodabeh
Ramazani, Ali
Conde, João
Danafar, Hossein
author_role author
author2 Ghaffarlou, Mohammadreza
Salehiabar, Marziyeh
Mousazadeh, Navid
Abhari, Fatemeh
Barsbay, Murat
Ertas, Yavuz Nuri
Rashidzadeh, Hamid
Mohammadi, Ali
Nasehi, Leila
Rezaeejam, Hamed
Davaran, Soodabeh
Ramazani, Ali
Conde, João
Danafar, Hossein
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Nosrati, Hamed
Ghaffarlou, Mohammadreza
Salehiabar, Marziyeh
Mousazadeh, Navid
Abhari, Fatemeh
Barsbay, Murat
Ertas, Yavuz Nuri
Rashidzadeh, Hamid
Mohammadi, Ali
Nasehi, Leila
Rezaeejam, Hamed
Davaran, Soodabeh
Ramazani, Ali
Conde, João
Danafar, Hossein
dc.subject.por.fl_str_mv Bismuth sulfide
Iron oxide
Janus nanoparticles
Radiosensitizer
ROS generation
X-ray irradiation
Biomedical Engineering
Biomaterials
Bioengineering
SDG 3 - Good Health and Well-being
topic Bismuth sulfide
Iron oxide
Janus nanoparticles
Radiosensitizer
ROS generation
X-ray irradiation
Biomedical Engineering
Biomaterials
Bioengineering
SDG 3 - Good Health and Well-being
description Funding Information: This work supported by the “ Iran National Science Foundation : INSF-98024375 ”, Iran's National Elites Foundation , and the “ University of Zanjan ”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325 . Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346 ). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192 ). Funding Information: This work supported by the “Iran National Science Foundation: INSF-98024375”, Iran's National Elites Foundation, and the “University of Zanjan”. We gratefully acknowledge the Zanjan University of Medical Science support. JC acknowledges financial support from the European Research Council - ERC Starting Grant 848325. Y.N. Ertas acknowledges funding support from the 2232 International Fellowship for Outstanding Researchers Program of TÜBİTAK (Project No: 118C346). MB acknowledges the financial support of the International Atomic Energy Agency (IAEA) under coordinated research project F22070 (IAEA Research Contract No: 23192). Publisher Copyright: © 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-09
2022-09-01T00:00:00Z
2023-06-20T22:20:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154203
url http://hdl.handle.net/10362/154203
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2772-9508
PURE: 46373680
https://doi.org/10.1016/j.bioadv.2022.213090
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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