Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine

Detalhes bibliográficos
Autor(a) principal: Leiro, V
Data de Publicação: 2017
Outros Autores: Santos, SD, Lopes, C, Pêgo, AP
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/120731
Resumo: Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, well-defined, highly branched and controllable structure, nanosize-scale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its infancy, the application of dendrimers as therapeutics or theranostic tools in central nervous system (CNS) disorders is already significant and has opened promising avenues in the treatment of many conditions where the inherent "smartness" of the dendritic structures is being explored to effectively target the CNS. Here we present an overview of the past and future challenges of the use of dendrimers to respond to one of the ultimate challenges in the (nano)medicine field: to attain CNS repair and regeneration.
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spelling Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful NanomedicineBlood-brain-barrier (BBB)Cell targetingDendrimersNeurodegenerative diseasesNeurological diseasesSurface functionalizationDendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, well-defined, highly branched and controllable structure, nanosize-scale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its infancy, the application of dendrimers as therapeutics or theranostic tools in central nervous system (CNS) disorders is already significant and has opened promising avenues in the treatment of many conditions where the inherent "smartness" of the dendritic structures is being explored to effectively target the CNS. Here we present an overview of the past and future challenges of the use of dendrimers to respond to one of the ultimate challenges in the (nano)medicine field: to attain CNS repair and regeneration.Wiley-VCH Verlag20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/120731eng1616-301X10.1002/adfm.201700313Leiro, VSantos, SDLopes, CPêgo, APinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:35:47Zoai:repositorio-aberto.up.pt:10216/120731Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:23:13.259707Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
title Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
spellingShingle Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
Leiro, V
Blood-brain-barrier (BBB)
Cell targeting
Dendrimers
Neurodegenerative diseases
Neurological diseases
Surface functionalization
title_short Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
title_full Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
title_fullStr Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
title_full_unstemmed Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
title_sort Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine
author Leiro, V
author_facet Leiro, V
Santos, SD
Lopes, C
Pêgo, AP
author_role author
author2 Santos, SD
Lopes, C
Pêgo, AP
author2_role author
author
author
dc.contributor.author.fl_str_mv Leiro, V
Santos, SD
Lopes, C
Pêgo, AP
dc.subject.por.fl_str_mv Blood-brain-barrier (BBB)
Cell targeting
Dendrimers
Neurodegenerative diseases
Neurological diseases
Surface functionalization
topic Blood-brain-barrier (BBB)
Cell targeting
Dendrimers
Neurodegenerative diseases
Neurological diseases
Surface functionalization
description Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, well-defined, highly branched and controllable structure, nanosize-scale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its infancy, the application of dendrimers as therapeutics or theranostic tools in central nervous system (CNS) disorders is already significant and has opened promising avenues in the treatment of many conditions where the inherent "smartness" of the dendritic structures is being explored to effectively target the CNS. Here we present an overview of the past and future challenges of the use of dendrimers to respond to one of the ultimate challenges in the (nano)medicine field: to attain CNS repair and regeneration.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/120731
url https://hdl.handle.net/10216/120731
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1616-301X
10.1002/adfm.201700313
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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