The cerebellum is causally involved in episodic memory under aging
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107110 https://doi.org/10.1007/s11357-023-00738-0 |
Resumo: | Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period - healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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The cerebellum is causally involved in episodic memory under agingCerebellumEpisodic memory declineNeurostimulationEpisodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period - healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging.Springer Nature2023-02-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107110http://hdl.handle.net/10316/107110https://doi.org/10.1007/s11357-023-00738-0eng2509-27152509-2723Almeida, ArmandoMartins, Ana R.Amaral, LéniaValério, DanielaBukhari, QasimSchu, GuilhermeNogueira, JoanaSpínola, MónicaSoleimani, GhazalehFernandes, FilipeSilva, Ana R.Fregni, FelipeSimis, MarcelSimões, MárioPeres, Andréinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-12T12:50:53Zoai:estudogeral.uc.pt:10316/107110Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:28.664318Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The cerebellum is causally involved in episodic memory under aging |
title |
The cerebellum is causally involved in episodic memory under aging |
spellingShingle |
The cerebellum is causally involved in episodic memory under aging Almeida, Armando Cerebellum Episodic memory decline Neurostimulation |
title_short |
The cerebellum is causally involved in episodic memory under aging |
title_full |
The cerebellum is causally involved in episodic memory under aging |
title_fullStr |
The cerebellum is causally involved in episodic memory under aging |
title_full_unstemmed |
The cerebellum is causally involved in episodic memory under aging |
title_sort |
The cerebellum is causally involved in episodic memory under aging |
author |
Almeida, Armando |
author_facet |
Almeida, Armando Martins, Ana R. Amaral, Lénia Valério, Daniela Bukhari, Qasim Schu, Guilherme Nogueira, Joana Spínola, Mónica Soleimani, Ghazaleh Fernandes, Filipe Silva, Ana R. Fregni, Felipe Simis, Marcel Simões, Mário Peres, André |
author_role |
author |
author2 |
Martins, Ana R. Amaral, Lénia Valério, Daniela Bukhari, Qasim Schu, Guilherme Nogueira, Joana Spínola, Mónica Soleimani, Ghazaleh Fernandes, Filipe Silva, Ana R. Fregni, Felipe Simis, Marcel Simões, Mário Peres, André |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Armando Martins, Ana R. Amaral, Lénia Valério, Daniela Bukhari, Qasim Schu, Guilherme Nogueira, Joana Spínola, Mónica Soleimani, Ghazaleh Fernandes, Filipe Silva, Ana R. Fregni, Felipe Simis, Marcel Simões, Mário Peres, André |
dc.subject.por.fl_str_mv |
Cerebellum Episodic memory decline Neurostimulation |
topic |
Cerebellum Episodic memory decline Neurostimulation |
description |
Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period - healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107110 http://hdl.handle.net/10316/107110 https://doi.org/10.1007/s11357-023-00738-0 |
url |
http://hdl.handle.net/10316/107110 https://doi.org/10.1007/s11357-023-00738-0 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2509-2715 2509-2723 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134121628270592 |