Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.

Detalhes bibliográficos
Autor(a) principal: Diniz, M J
Data de Publicação: 1992
Outros Autores: Dias Francisco, F, Tavares, M L, Leal, I
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3230
Resumo: Factor VIII inhibitors arise in 5% to 15% of patients with hemophilia A in response to infusion to factor VIII concentrates and make the treatment of bleeding episodes extremely difficult. Various therapeutic approaches have been tried the decision depending on the type of haemorrhage, the antibody's titre and whether the patient has a low or high response. We report the clinical experience in 13 hemophiliacs with inhibitors to factor VIII. Prothrombin complex concentrates were administered with favorable effects in the most common haemorrhagic episodes, in the majority of patients. In two patients activated prothrombin complex concentrates were administered and in one case plasma exchange was made before high doses of factor VIII. These therapeutic approaches proved to be very effective in the control of hemostasis.
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spelling Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.Hemofílicos com inibidor. Experiência do Centro de Acção Médica de Hemofilia do Hospital de S. José.Factor VIII inhibitors arise in 5% to 15% of patients with hemophilia A in response to infusion to factor VIII concentrates and make the treatment of bleeding episodes extremely difficult. Various therapeutic approaches have been tried the decision depending on the type of haemorrhage, the antibody's titre and whether the patient has a low or high response. We report the clinical experience in 13 hemophiliacs with inhibitors to factor VIII. Prothrombin complex concentrates were administered with favorable effects in the most common haemorrhagic episodes, in the majority of patients. In two patients activated prothrombin complex concentrates were administered and in one case plasma exchange was made before high doses of factor VIII. These therapeutic approaches proved to be very effective in the control of hemostasis.Factor VIII inhibitors arise in 5% to 15% of patients with hemophilia A in response to infusion to factor VIII concentrates and make the treatment of bleeding episodes extremely difficult. Various therapeutic approaches have been tried the decision depending on the type of haemorrhage, the antibody's titre and whether the patient has a low or high response. We report the clinical experience in 13 hemophiliacs with inhibitors to factor VIII. Prothrombin complex concentrates were administered with favorable effects in the most common haemorrhagic episodes, in the majority of patients. In two patients activated prothrombin complex concentrates were administered and in one case plasma exchange was made before high doses of factor VIII. These therapeutic approaches proved to be very effective in the control of hemostasis.Ordem dos Médicos1992-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3230oai:ojs.www.actamedicaportuguesa.com:article/3230Acta Médica Portuguesa; Vol. 5 No. 4 (1992): Abril; 178-80Acta Médica Portuguesa; Vol. 5 N.º 4 (1992): Abril; 178-801646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3230https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3230/2569Diniz, M JDias Francisco, FTavares, M LLeal, Iinfo:eu-repo/semantics/openAccess2022-12-20T11:01:56Zoai:ojs.www.actamedicaportuguesa.com:article/3230Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:14.591669Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
Hemofílicos com inibidor. Experiência do Centro de Acção Médica de Hemofilia do Hospital de S. José.
title Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
spellingShingle Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
Diniz, M J
title_short Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
title_full Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
title_fullStr Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
title_full_unstemmed Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
title_sort Hemophiliacs with inhibitor. Experience at the Center of Medical Action for Hemophilia of the S. José Hospital.
author Diniz, M J
author_facet Diniz, M J
Dias Francisco, F
Tavares, M L
Leal, I
author_role author
author2 Dias Francisco, F
Tavares, M L
Leal, I
author2_role author
author
author
dc.contributor.author.fl_str_mv Diniz, M J
Dias Francisco, F
Tavares, M L
Leal, I
description Factor VIII inhibitors arise in 5% to 15% of patients with hemophilia A in response to infusion to factor VIII concentrates and make the treatment of bleeding episodes extremely difficult. Various therapeutic approaches have been tried the decision depending on the type of haemorrhage, the antibody's titre and whether the patient has a low or high response. We report the clinical experience in 13 hemophiliacs with inhibitors to factor VIII. Prothrombin complex concentrates were administered with favorable effects in the most common haemorrhagic episodes, in the majority of patients. In two patients activated prothrombin complex concentrates were administered and in one case plasma exchange was made before high doses of factor VIII. These therapeutic approaches proved to be very effective in the control of hemostasis.
publishDate 1992
dc.date.none.fl_str_mv 1992-04-30
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dc.language.iso.fl_str_mv por
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 5 No. 4 (1992): Abril; 178-80
Acta Médica Portuguesa; Vol. 5 N.º 4 (1992): Abril; 178-80
1646-0758
0870-399X
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