Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation

Detalhes bibliográficos
Autor(a) principal: Corrêa, Rúbia C.G.
Data de Publicação: 2017
Outros Autores: Haminiuk, Charles Windson Isidoro, Barros, Lillian, Dias, Maria Inês, Calhelha, Ricardo C., Kato-Schwartz, Camila Gabriel, Correa, Vanesa G., Peralta, Rosane M., Ferreira, Isabel C.F.R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/15254
Resumo: Grape pomace is an abundant/accessible food industry by-product that contains a wide range of phenolic compounds, which have been related to several health benefits and bioactivities. The aim of this study was to mimic the gastrointestinal digestion and the colonic fermentation of Merlot grape pomace, in order to unravel possible phytochemical contents reductions and the processes associated with them, as a tentative to relate the phenolic compound profiles of the extracts with their biological properties. LC-DAD-ESI/MS suggested that the in vitro digestion process promoted drastic qualitative and quantitative reductions in the phenolic compounds profile of the Merlot grape pomace crude extract. Such alterations could be related to the decreases of some bioactivities of the extract, which seems to be the case of antioxidant and antibacterial properties, although not in a directly proportional manner. However, the simulated colonic fermentation seems to have a positive effect over the extract's antiproliferative potential.
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spelling Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentationAntiproliferative effectsIn vitro fermentationIn vitro gastrointestinal digestionMerlot grape pomacePhenolic compoundsGrape pomace is an abundant/accessible food industry by-product that contains a wide range of phenolic compounds, which have been related to several health benefits and bioactivities. The aim of this study was to mimic the gastrointestinal digestion and the colonic fermentation of Merlot grape pomace, in order to unravel possible phytochemical contents reductions and the processes associated with them, as a tentative to relate the phenolic compound profiles of the extracts with their biological properties. LC-DAD-ESI/MS suggested that the in vitro digestion process promoted drastic qualitative and quantitative reductions in the phenolic compounds profile of the Merlot grape pomace crude extract. Such alterations could be related to the decreases of some bioactivities of the extract, which seems to be the case of antioxidant and antibacterial properties, although not in a directly proportional manner. However, the simulated colonic fermentation seems to have a positive effect over the extract's antiproliferative potential.R.C.G. Correa thank Coordenação de Aperfeiçoamento do Pessoal do Ensino Superior (CAPES) and Fundação Araucária for the financial support provided for her post-graduate studies in Federal University of Technology - Paraná (contract 100/2014). Authors C.G. Kato and V.G. Correa thank CAPES for the financial support provided for their post-graduate studies in the State University of Maringá. R.M. Peralta (Project number 307944/2015-8) and C.W.I. Haminiuk (project number 303238/2013-5 and 304978/2016-7) are research grant recipients of Conselho Nacional de Desenvolvimento Científico e Tecnologia (CNPq). The authors are also thankful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Program PT2020 for financial support to CIMO (UID/AGR/00690/2013), L. Barros (SFRH/BPD/107855/2015) and M.I. Dias (SFRH/BD/84485/2012) grants. To POCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by ERDF, through POCI-COMPETE2020 and FCT.Biblioteca Digital do IPBCorrêa, Rúbia C.G.Haminiuk, Charles Windson IsidoroBarros, LillianDias, Maria InêsCalhelha, Ricardo C.Kato-Schwartz, Camila GabrielCorrea, Vanesa G.Peralta, Rosane M.Ferreira, Isabel C.F.R.2018-01-25T10:00:00Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15254engCorrêa, Rúbia C.G.; Haminiuk, Charles W.I.; Barros, Lillian; Dias, Maria Inês; Calhelha, Ricardo C.; Kato, Camila G.; Correa, Vanesa G.; Peralta, Rosane M.; Ferreira, Isabel C.F.R. (2017). Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation. Journal of Functional Foods. ISSN 1756-4646. 36, p. 410-4171756-464610.1016/j.jff.2017.07.030info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:35:40Zoai:bibliotecadigital.ipb.pt:10198/15254Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:04:53.310300Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
title Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
spellingShingle Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
Corrêa, Rúbia C.G.
Antiproliferative effects
In vitro fermentation
In vitro gastrointestinal digestion
Merlot grape pomace
Phenolic compounds
title_short Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
title_full Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
title_fullStr Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
title_full_unstemmed Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
title_sort Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation
author Corrêa, Rúbia C.G.
author_facet Corrêa, Rúbia C.G.
Haminiuk, Charles Windson Isidoro
Barros, Lillian
Dias, Maria Inês
Calhelha, Ricardo C.
Kato-Schwartz, Camila Gabriel
Correa, Vanesa G.
Peralta, Rosane M.
Ferreira, Isabel C.F.R.
author_role author
author2 Haminiuk, Charles Windson Isidoro
Barros, Lillian
Dias, Maria Inês
Calhelha, Ricardo C.
Kato-Schwartz, Camila Gabriel
Correa, Vanesa G.
Peralta, Rosane M.
Ferreira, Isabel C.F.R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Corrêa, Rúbia C.G.
Haminiuk, Charles Windson Isidoro
Barros, Lillian
Dias, Maria Inês
Calhelha, Ricardo C.
Kato-Schwartz, Camila Gabriel
Correa, Vanesa G.
Peralta, Rosane M.
Ferreira, Isabel C.F.R.
dc.subject.por.fl_str_mv Antiproliferative effects
In vitro fermentation
In vitro gastrointestinal digestion
Merlot grape pomace
Phenolic compounds
topic Antiproliferative effects
In vitro fermentation
In vitro gastrointestinal digestion
Merlot grape pomace
Phenolic compounds
description Grape pomace is an abundant/accessible food industry by-product that contains a wide range of phenolic compounds, which have been related to several health benefits and bioactivities. The aim of this study was to mimic the gastrointestinal digestion and the colonic fermentation of Merlot grape pomace, in order to unravel possible phytochemical contents reductions and the processes associated with them, as a tentative to relate the phenolic compound profiles of the extracts with their biological properties. LC-DAD-ESI/MS suggested that the in vitro digestion process promoted drastic qualitative and quantitative reductions in the phenolic compounds profile of the Merlot grape pomace crude extract. Such alterations could be related to the decreases of some bioactivities of the extract, which seems to be the case of antioxidant and antibacterial properties, although not in a directly proportional manner. However, the simulated colonic fermentation seems to have a positive effect over the extract's antiproliferative potential.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-01-25T10:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/15254
url http://hdl.handle.net/10198/15254
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Corrêa, Rúbia C.G.; Haminiuk, Charles W.I.; Barros, Lillian; Dias, Maria Inês; Calhelha, Ricardo C.; Kato, Camila G.; Correa, Vanesa G.; Peralta, Rosane M.; Ferreira, Isabel C.F.R. (2017). Stability and biological activity of Merlot (Vitis vinifera) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation. Journal of Functional Foods. ISSN 1756-4646. 36, p. 410-417
1756-4646
10.1016/j.jff.2017.07.030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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