Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice

Detalhes bibliográficos
Autor(a) principal: Rocha, João
Data de Publicação: 2020
Outros Autores: Leandro, Raquel, Direito, Rosa, Gonçalves, Margarida, Duarte, Maria Paula, Fernandes, Adelaide, Sepodes, Bruno, Figueira, Maria Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114530
Resumo: UIDB/04077/2020
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spelling Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in miceCarrageenan-induced paw edemaColitisColorectal cancerInflammationInflammatory bowel diseasesSatureja hortensisSummer SavoryTNBS-induced colitisMaterials Science(all)InstrumentationEngineering(all)Process Chemistry and TechnologyComputer Science ApplicationsFluid Flow and Transfer ProcessesSDG 3 - Good Health and Well-beingUIDB/04077/2020Summer Savory (Satureja hortensis L.) is a plant traditionally used as a food spice in the Mediterranean region. Surprisingly, not much is known about the health beneficial effects of its phenolic-rich extracts. The majority of publications have always focused on the properties of their essential oil. One of the main phenolic compounds of Summer Savory is rosmarinic acid, which has demonstrated anti-inflammatory outcomes in several animal models of inflammatory-mediated diseases. Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease, in addition to Ulcerative Colitis and Crohn’s Disease, frequently related with increased morbidity and even mortality due to the complications associated, including colorectal cancer. Our work has shown, to our knowledge, for the first time, that administration of a phenolic extract of Summer Savory in a mouse model of Ulcerative Colitis led to the reduction of several markers for intestinal injury, including reduction of inducible nitric oxide synthase (iNOS) and Cyclooxygenase-2 (COX-2 or prostaglandin-endoperoxide synthase) expression, two well-known mediators of tissue inflammation and progression to cancer and led also to a reduction of the mortality. Given the chemical constitution found in the extract and the preclinical evidence of a beneficial effect of polyphenols in inflammatory processes, an opportunity arises for pharmacological modulation of pathways relevant for IBD and progression to cancer with phenolic-rich extracts.MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de RecursosDCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)RUNRocha, JoãoLeandro, RaquelDireito, RosaGonçalves, MargaridaDuarte, Maria PaulaFernandes, AdelaideSepodes, BrunoFigueira, Maria Eduardo2021-03-26T23:26:47Z2020-12-012020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article19application/pdfhttp://hdl.handle.net/10362/114530eng2076-3417PURE: 27771100https://doi.org/10.3390/app10238465info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:57:13Zoai:run.unl.pt:10362/114530Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:33.835371Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
title Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
spellingShingle Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
Rocha, João
Carrageenan-induced paw edema
Colitis
Colorectal cancer
Inflammation
Inflammatory bowel diseases
Satureja hortensis
Summer Savory
TNBS-induced colitis
Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
title_short Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
title_full Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
title_fullStr Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
title_full_unstemmed Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
title_sort Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
author Rocha, João
author_facet Rocha, João
Leandro, Raquel
Direito, Rosa
Gonçalves, Margarida
Duarte, Maria Paula
Fernandes, Adelaide
Sepodes, Bruno
Figueira, Maria Eduardo
author_role author
author2 Leandro, Raquel
Direito, Rosa
Gonçalves, Margarida
Duarte, Maria Paula
Fernandes, Adelaide
Sepodes, Bruno
Figueira, Maria Eduardo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)
RUN
dc.contributor.author.fl_str_mv Rocha, João
Leandro, Raquel
Direito, Rosa
Gonçalves, Margarida
Duarte, Maria Paula
Fernandes, Adelaide
Sepodes, Bruno
Figueira, Maria Eduardo
dc.subject.por.fl_str_mv Carrageenan-induced paw edema
Colitis
Colorectal cancer
Inflammation
Inflammatory bowel diseases
Satureja hortensis
Summer Savory
TNBS-induced colitis
Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
topic Carrageenan-induced paw edema
Colitis
Colorectal cancer
Inflammation
Inflammatory bowel diseases
Satureja hortensis
Summer Savory
TNBS-induced colitis
Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes
SDG 3 - Good Health and Well-being
description UIDB/04077/2020
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
2020-12-01T00:00:00Z
2021-03-26T23:26:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114530
url http://hdl.handle.net/10362/114530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3417
PURE: 27771100
https://doi.org/10.3390/app10238465
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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