Chemokine-directed tumor microenvironment modulation in cancer immunotherapy

Detalhes bibliográficos
Autor(a) principal: Bule, Pedro
Data de Publicação: 2021
Outros Autores: Aguiar, Sandra Isabel, Aires Da Silva, Frederico, Dias, Joana Nunes Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/22459
Resumo: Research Areas: Biochemistry & Molecular Biology. Chemistry
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spelling Chemokine-directed tumor microenvironment modulation in cancer immunotherapyCancerChemokineChemokine receptorImmunotherapyTumoral microenvironmentResearch Areas: Biochemistry & Molecular Biology. ChemistryChemokines are a large family of small chemotactic cytokines that coordinates immune cell trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the tumor, thereby shaping the tumor microenvironment immune profile, often towards a pro-tumorigenic state. Furthermore, chemokines can directly target non-immune cells in the tumor microenvironment, including cancer, stromal and vascular endothelial cells. As such, chemokines participate in several cancer development processes such as angiogenesis, metastasis, cancer cell proliferation, stemness and invasiveness, and are therefore key determinants of disease progression, with a strong influence in patient prognosis and response to therapy. Due to their multifaceted role in the tumor immune response and tumor biology, the chemokine network has emerged as a potential immunotherapy target. Under the present review, we provide a general overview of chemokine effects on several tumoral processes, as well as a description of the currently available chemokine-directed therapies, highlighting their potential both as monotherapy or in combination with standard chemotherapy or other immunotherapies. Finally, we discuss the most critical challenges and prospects of developing targeted chemokines as therapeutic options.MDPIRepositório da Universidade de LisboaBule, PedroAguiar, Sandra IsabelAires Da Silva, FredericoDias, Joana Nunes Ribeiro2021-11-01T20:22:21Z2021-09-102021-09-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22459engBule P, Aguiar SI, Aires da Silva F, Dias JNR. 2021. Chemokine-Directed tumor microenvironment modulation in cancer immunotherapy. International Journal of Molecular Sciences 22(18):9804. doi:10.3390/ijms2218980410.3390/ijms221898041422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:51:59ZPortal AgregadorONG
dc.title.none.fl_str_mv Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
title Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
spellingShingle Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
Bule, Pedro
Cancer
Chemokine
Chemokine receptor
Immunotherapy
Tumoral microenvironment
title_short Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
title_full Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
title_fullStr Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
title_full_unstemmed Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
title_sort Chemokine-directed tumor microenvironment modulation in cancer immunotherapy
author Bule, Pedro
author_facet Bule, Pedro
Aguiar, Sandra Isabel
Aires Da Silva, Frederico
Dias, Joana Nunes Ribeiro
author_role author
author2 Aguiar, Sandra Isabel
Aires Da Silva, Frederico
Dias, Joana Nunes Ribeiro
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bule, Pedro
Aguiar, Sandra Isabel
Aires Da Silva, Frederico
Dias, Joana Nunes Ribeiro
dc.subject.por.fl_str_mv Cancer
Chemokine
Chemokine receptor
Immunotherapy
Tumoral microenvironment
topic Cancer
Chemokine
Chemokine receptor
Immunotherapy
Tumoral microenvironment
description Research Areas: Biochemistry & Molecular Biology. Chemistry
publishDate 2021
dc.date.none.fl_str_mv 2021-11-01T20:22:21Z
2021-09-10
2021-09-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/22459
url http://hdl.handle.net/10400.5/22459
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bule P, Aguiar SI, Aires da Silva F, Dias JNR. 2021. Chemokine-Directed tumor microenvironment modulation in cancer immunotherapy. International Journal of Molecular Sciences 22(18):9804. doi:10.3390/ijms22189804
10.3390/ijms22189804
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.mail.fl_str_mv
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