CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL

Detalhes bibliográficos
Autor(a) principal: Matos, Diogo
Data de Publicação: 2015
Outros Autores: Barreiros, Hugo, Coelho, Ricardo, Bártolo, Elvira, Fonseca, Ana Glória, Cunha, Vitória
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.73.2.379
Resumo: Propylthiouracil (PTU) is widely used in the treatment of Hyperthyroidism. Usually well tolerated, it is though associated with antineutrophil cytoplasmic antibodies (ANCA) and, less frequently, with late-onset ANCA positive vasculitis. The authors describe the clinical case of a 45-year-old female patient with Graves’ disease for which she was being treated with PTU since 3 years before, who developed an ANCA-positive cutaneous leukocytoclastic vasculitis without systemic involvement. Initially seen as idiopathic the vasculitis was posteriorly associated with PTU. The drug was discontinued with a progressive and maintained recovery. The patient remains asymptomatic with 3 years of follow-up.
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spelling CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACILVASCULITE CUTÂNEA LEUCOCITOCLÁSICA INDUZIDA PELO PROPILTIOURACILOAntibodiesantineutrophil cytoplasmicPropylthiouraciladverse effectsVasculitisleukocytoclasticcutaneousAnticorpos anticitoplasma dos neutrófilosPropiltiouraciloVasculite leucocitoclásicaPropylthiouracil (PTU) is widely used in the treatment of Hyperthyroidism. Usually well tolerated, it is though associated with antineutrophil cytoplasmic antibodies (ANCA) and, less frequently, with late-onset ANCA positive vasculitis. The authors describe the clinical case of a 45-year-old female patient with Graves’ disease for which she was being treated with PTU since 3 years before, who developed an ANCA-positive cutaneous leukocytoclastic vasculitis without systemic involvement. Initially seen as idiopathic the vasculitis was posteriorly associated with PTU. The drug was discontinued with a progressive and maintained recovery. The patient remains asymptomatic with 3 years of follow-up.O propiltiouracilo (PTU) é um fármaco largamente usado no tratamento do hipertiroidismo. Em regra bem tolerado, está contudo fortemente associado a anticorpos anticitoplasma dos neutrófilos (ANCA) e, numa minoria dos casos, a vasculite com ANCA positivos, que caracteristicamente ocorre tardiamente. Os autores descrevem o caso de uma mulher de 45 anos, medicada havia 3 anos com PTU no contexto de doença de Graves, observada por quadro clinico sugestivo de vasculite cutânea leucocitoclásica ANCA positiva sem envolvimento sistémico, a qual foi inicialmente interpretada como idiopática e posteriormente associada à toma de PTU. Após a suspensão deste fármaco, assistiu-se a uma melhoria progressiva e mantida, permanecendo a doente assintomática com 3 anos de seguimento.Sociedade Portuguesa de Dermatologia e Venereologia2015-07-01T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.73.2.379oai:ojs.revista.spdv.com.pt:article/379Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 2 (2015): Abril / Junho; 287-291Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 2 (2015): Abril / Junho; 287-2912182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/379https://doi.org/10.29021/spdv.73.2.379https://revista.spdv.com.pt/index.php/spdv/article/view/379/347Matos, DiogoBarreiros, HugoCoelho, RicardoBártolo, ElviraFonseca, Ana GlóriaCunha, Vitóriainfo:eu-repo/semantics/openAccess2022-10-06T12:34:53Zoai:ojs.revista.spdv.com.pt:article/379Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:53.288818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
VASCULITE CUTÂNEA LEUCOCITOCLÁSICA INDUZIDA PELO PROPILTIOURACILO
title CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
spellingShingle CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
Matos, Diogo
Antibodies
antineutrophil cytoplasmic
Propylthiouracil
adverse effects
Vasculitis
leukocytoclastic
cutaneous
Anticorpos anticitoplasma dos neutrófilos
Propiltiouracilo
Vasculite leucocitoclásica
title_short CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
title_full CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
title_fullStr CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
title_full_unstemmed CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
title_sort CUTANEOUS LEUKOCYTOCLASTIC VASCULITIS INDUCED BY PROPYLTHIOURACIL
author Matos, Diogo
author_facet Matos, Diogo
Barreiros, Hugo
Coelho, Ricardo
Bártolo, Elvira
Fonseca, Ana Glória
Cunha, Vitória
author_role author
author2 Barreiros, Hugo
Coelho, Ricardo
Bártolo, Elvira
Fonseca, Ana Glória
Cunha, Vitória
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Matos, Diogo
Barreiros, Hugo
Coelho, Ricardo
Bártolo, Elvira
Fonseca, Ana Glória
Cunha, Vitória
dc.subject.por.fl_str_mv Antibodies
antineutrophil cytoplasmic
Propylthiouracil
adverse effects
Vasculitis
leukocytoclastic
cutaneous
Anticorpos anticitoplasma dos neutrófilos
Propiltiouracilo
Vasculite leucocitoclásica
topic Antibodies
antineutrophil cytoplasmic
Propylthiouracil
adverse effects
Vasculitis
leukocytoclastic
cutaneous
Anticorpos anticitoplasma dos neutrófilos
Propiltiouracilo
Vasculite leucocitoclásica
description Propylthiouracil (PTU) is widely used in the treatment of Hyperthyroidism. Usually well tolerated, it is though associated with antineutrophil cytoplasmic antibodies (ANCA) and, less frequently, with late-onset ANCA positive vasculitis. The authors describe the clinical case of a 45-year-old female patient with Graves’ disease for which she was being treated with PTU since 3 years before, who developed an ANCA-positive cutaneous leukocytoclastic vasculitis without systemic involvement. Initially seen as idiopathic the vasculitis was posteriorly associated with PTU. The drug was discontinued with a progressive and maintained recovery. The patient remains asymptomatic with 3 years of follow-up.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.73.2.379
oai:ojs.revista.spdv.com.pt:article/379
url https://doi.org/10.29021/spdv.73.2.379
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/379
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/379
https://doi.org/10.29021/spdv.73.2.379
https://revista.spdv.com.pt/index.php/spdv/article/view/379/347
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 73 No 2 (2015): Abril / Junho; 287-291
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 73 n. 2 (2015): Abril / Junho; 287-291
2182-2409
2182-2395
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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