Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials

Detalhes bibliográficos
Autor(a) principal: Fonte, Mélanie
Data de Publicação: 2019
Outros Autores: Fagundes, Natália, Gomes, Ana, Ferraz, Ricardo, Prudêncio, Cristina, Araújo, Maria João, Gomes, Paula, Teixeira, Cátia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14182
Resumo: A multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.
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spelling Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarialsAcridineAntimalarialHeteroaromaticHeterocyclic chemistryMepacrineQuinacrineA multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.ElsevierRepositório Científico do Instituto Politécnico do PortoFonte, MélanieFagundes, NatáliaGomes, AnaFerraz, RicardoPrudêncio, CristinaAraújo, Maria JoãoGomes, PaulaTeixeira, Cátia2022-05-02T00:30:47Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14182engFonte, M., Fagundes, N., Gomes, A., Ferraz, R., Prudêncio, C., Araújo, M. J., Gomes, P., & Teixeira, C. (2019). Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials. Tetrahedron Letters, 60(17), 1166–1169. https://doi.org/10.1016/j.tetlet.2019.03.05210.1016/j.tetlet.2019.03.052info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:05Zoai:recipp.ipp.pt:10400.22/14182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:00.147599Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
title Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
spellingShingle Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
Fonte, Mélanie
Acridine
Antimalarial
Heteroaromatic
Heterocyclic chemistry
Mepacrine
Quinacrine
title_short Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
title_full Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
title_fullStr Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
title_full_unstemmed Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
title_sort Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
author Fonte, Mélanie
author_facet Fonte, Mélanie
Fagundes, Natália
Gomes, Ana
Ferraz, Ricardo
Prudêncio, Cristina
Araújo, Maria João
Gomes, Paula
Teixeira, Cátia
author_role author
author2 Fagundes, Natália
Gomes, Ana
Ferraz, Ricardo
Prudêncio, Cristina
Araújo, Maria João
Gomes, Paula
Teixeira, Cátia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Fonte, Mélanie
Fagundes, Natália
Gomes, Ana
Ferraz, Ricardo
Prudêncio, Cristina
Araújo, Maria João
Gomes, Paula
Teixeira, Cátia
dc.subject.por.fl_str_mv Acridine
Antimalarial
Heteroaromatic
Heterocyclic chemistry
Mepacrine
Quinacrine
topic Acridine
Antimalarial
Heteroaromatic
Heterocyclic chemistry
Mepacrine
Quinacrine
description A multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2022-05-02T00:30:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14182
url http://hdl.handle.net/10400.22/14182
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fonte, M., Fagundes, N., Gomes, A., Ferraz, R., Prudêncio, C., Araújo, M. J., Gomes, P., & Teixeira, C. (2019). Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials. Tetrahedron Letters, 60(17), 1166–1169. https://doi.org/10.1016/j.tetlet.2019.03.052
10.1016/j.tetlet.2019.03.052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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