Monocyte-mediated T cell suppression by HIV-2 envelope proteins

Detalhes bibliográficos
Autor(a) principal: Cavaleiro, R.
Data de Publicação: 2007
Outros Autores: Brunn, G. J., Albuquerque, A. S., Victorino, R. M., Platt, J. L., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18304
Resumo: © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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spelling Monocyte-mediated T cell suppression by HIV-2 envelope proteinsHIVHost/pathogen interactionsImmunopathologyMonocytesToll-like receptors© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimHIV-2 is associated with an attenuated form of HIV disease. We investigate here the immunosuppressive effects of the HIV-2 envelope protein, gp105. We found that gp105 suppresses activation of T cells through a monocyte-mediated mechanism. Suppression of T cell activation by gp105 depends on contact between monocytes and T cells, but not on CD4+CD25+ T cells. The TLR4 pathway is likely involved, since gp105 activates TLR4 signaling and induces TNF-α production by monocytes. Immunosuppression is viewed as the main pathophysiologic consequence of infection by HIV. However, the main immunologic defect caused by HIV, depletion of T cells, requires T cell activation. Our findings are consistent with a new concept that HIV-2 envelope proteins act on monocytes to suppress T cell activation and that this property may contribute to the benign course of HIV-2. We hypothesize that the HIV-2 envelope immunosuppressive properties limit bursts of T cell activation, thus reducing viremia and contributing to the slow rate of disease progression that characterizes HIV-2 disease.NIBSC Centralized Facility for AIDS Reagents supported by EU Programme EVA (contract QLK2-CT-1999–00609) and the UK Medical Research Council for providing recombinant HIV-1 gp120IIIB and HIV-2 gp105ROD; and the Portuguese Institute of Blood for providing the buffy coats. This work was supported by grants from “Funda ção para a Ciência e a Tecnologia” (FCT) and “Comissão Nacional de Luta Contra a SIDA” (PSIDA/ESP/49655/2003 to A. E. S.). R. C. received a scholarship from FCT.WileyRepositório da Universidade de LisboaCavaleiro, R.Brunn, G. J.Albuquerque, A. S.Victorino, R. M.Platt, J. L.Sousa, A. E.2015-06-17T13:48:55Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18304engEur. J. Immunol. 2007. 37: 3435–34440014-2980http://onlinelibrary.wiley.com/doi/10.1002/eji.200737511/fullmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:31Zoai:repositorio.ul.pt:10451/18304Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:53.782190Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Monocyte-mediated T cell suppression by HIV-2 envelope proteins
title Monocyte-mediated T cell suppression by HIV-2 envelope proteins
spellingShingle Monocyte-mediated T cell suppression by HIV-2 envelope proteins
Cavaleiro, R.
HIV
Host/pathogen interactions
Immunopathology
Monocytes
Toll-like receptors
title_short Monocyte-mediated T cell suppression by HIV-2 envelope proteins
title_full Monocyte-mediated T cell suppression by HIV-2 envelope proteins
title_fullStr Monocyte-mediated T cell suppression by HIV-2 envelope proteins
title_full_unstemmed Monocyte-mediated T cell suppression by HIV-2 envelope proteins
title_sort Monocyte-mediated T cell suppression by HIV-2 envelope proteins
author Cavaleiro, R.
author_facet Cavaleiro, R.
Brunn, G. J.
Albuquerque, A. S.
Victorino, R. M.
Platt, J. L.
Sousa, A. E.
author_role author
author2 Brunn, G. J.
Albuquerque, A. S.
Victorino, R. M.
Platt, J. L.
Sousa, A. E.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cavaleiro, R.
Brunn, G. J.
Albuquerque, A. S.
Victorino, R. M.
Platt, J. L.
Sousa, A. E.
dc.subject.por.fl_str_mv HIV
Host/pathogen interactions
Immunopathology
Monocytes
Toll-like receptors
topic HIV
Host/pathogen interactions
Immunopathology
Monocytes
Toll-like receptors
description © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
2015-06-17T13:48:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18304
url http://hdl.handle.net/10451/18304
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur. J. Immunol. 2007. 37: 3435–3444
0014-2980
http://onlinelibrary.wiley.com/doi/10.1002/eji.200737511/full
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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