Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices

Detalhes bibliográficos
Autor(a) principal: Costa, Rui Filipe Ramos
Data de Publicação: 2022
Outros Autores: Reis, R. L., Pashkuleva, I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/75603
Resumo: Published online: 19 Jan 2022
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spelling Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devicesChondroitin sulfateDermatan sulfateElectrostatic complexationHeparinHyaluronic acidKeratan sulfatePolyelectrolytesSupramolecular assemblyScience & TechnologyPublished online: 19 Jan 2022The innate negative charge of glycosaminoglycans (GAG) is in the origin of their bioactivity: it drives their spontaneous complexation with positively charged biomolecules and ions, regulating homeostatic functions by protein stabilization, protection and activation. Copycatting these interactions enables different supramolecular approaches towards the assembly of biofunctional devices. Such approaches allow processing under physiological conditions and thus, they are of unprecedented biocompliance for device build-up compared to conventional methods based on chemical cross-linkers, volatile and organic solvents, and high temperatures. We review different set-ups based on GAG electrostatic complexation and showcase their application towards the development of diverse therapeutic systems. We also discuss challenges associated with GAG complexation into intricate three-dimensional networks holding back the widespread use of these methods. Finally, we anticipate that conscious choice of GAG with distinct polyanionic strength and specific bioactivity will make possible the fabrication of constructs with personalized and customized properties in the nearest future.This work was supported by Fundação para a Ciência e a Tecnologia: [Grant Number CEECIND/02842/2017]; Fundação para a Ciência e a Tecnologia: [Grant Number PTDC/CTM-REF/0022/2020]; Fundação para a Ciência e a Tecnologia: [Grant Number PTDC/BTM-MAT/28327/2017].Taylor & FrancisUniversidade do MinhoCosta, Rui Filipe RamosReis, R. L.Pashkuleva, I.2022-012022-01-01T00:00:00Z2024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/75603engCosta R. R., Reis R. L., Pashkuleva I. Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices, International Materials Reviews, doi:10.1080/09506608.2022.2026860, 20220950-66081743-280410.1080/09506608.2022.2026860https://www.tandfonline.com/doi/full/10.1080/09506608.2022.2026860info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:55ZPortal AgregadorONG
dc.title.none.fl_str_mv Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
title Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
spellingShingle Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
Costa, Rui Filipe Ramos
Chondroitin sulfate
Dermatan sulfate
Electrostatic complexation
Heparin
Hyaluronic acid
Keratan sulfate
Polyelectrolytes
Supramolecular assembly
Science & Technology
title_short Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
title_full Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
title_fullStr Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
title_full_unstemmed Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
title_sort Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices
author Costa, Rui Filipe Ramos
author_facet Costa, Rui Filipe Ramos
Reis, R. L.
Pashkuleva, I.
author_role author
author2 Reis, R. L.
Pashkuleva, I.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, Rui Filipe Ramos
Reis, R. L.
Pashkuleva, I.
dc.subject.por.fl_str_mv Chondroitin sulfate
Dermatan sulfate
Electrostatic complexation
Heparin
Hyaluronic acid
Keratan sulfate
Polyelectrolytes
Supramolecular assembly
Science & Technology
topic Chondroitin sulfate
Dermatan sulfate
Electrostatic complexation
Heparin
Hyaluronic acid
Keratan sulfate
Polyelectrolytes
Supramolecular assembly
Science & Technology
description Published online: 19 Jan 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-01
2022-01-01T00:00:00Z
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/75603
url https://hdl.handle.net/1822/75603
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa R. R., Reis R. L., Pashkuleva I. Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices, International Materials Reviews, doi:10.1080/09506608.2022.2026860, 2022
0950-6608
1743-2804
10.1080/09506608.2022.2026860
https://www.tandfonline.com/doi/full/10.1080/09506608.2022.2026860
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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