Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3493 |
Resumo: | The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency. |
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Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International PerspectiveChildHumansGrowth DisordersHuman Growth HormoneHDE END PEDThe Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.Karger Publishers Open AccessRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECollett-Solberg, PFAmbler, GBackeljauw, PFBidlingmaier, MBiller, BMKBoguszewski, MCSCheung, PTChoong, CSYCohen, LECohen, PDauber, ADeal, CLGong, CHasegawa, YHoffman, ARHofman, PLHorikawa, RJorge, AALJuul, AKamenický, PKhadilkar, VKopchick, JJKriström, BLopes, MLLuo, XMiller, BSMisra, MNetchineRadovick, SRanke, MBRogol, ADRosenfeld, RGSaenger, PWit, JMWoelfle, J2020-08-10T14:33:12Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3493engHorm Res Paediatr . 2019;92(1):1-1410.1159/000502231info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:43:16Zoai:repositorio.chlc.min-saude.pt:10400.17/3493Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:48.249403Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
title |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
spellingShingle |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective Collett-Solberg, PF Child Humans Growth Disorders Human Growth Hormone HDE END PED |
title_short |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
title_full |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
title_fullStr |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
title_full_unstemmed |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
title_sort |
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective |
author |
Collett-Solberg, PF |
author_facet |
Collett-Solberg, PF Ambler, G Backeljauw, PF Bidlingmaier, M Biller, BMK Boguszewski, MCS Cheung, PT Choong, CSY Cohen, LE Cohen, P Dauber, A Deal, CL Gong, C Hasegawa, Y Hoffman, AR Hofman, PL Horikawa, R Jorge, AAL Juul, A Kamenický, P Khadilkar, V Kopchick, JJ Kriström, B Lopes, ML Luo, X Miller, BS Misra, M Netchine Radovick, S Ranke, MB Rogol, AD Rosenfeld, RG Saenger, P Wit, JM Woelfle, J |
author_role |
author |
author2 |
Ambler, G Backeljauw, PF Bidlingmaier, M Biller, BMK Boguszewski, MCS Cheung, PT Choong, CSY Cohen, LE Cohen, P Dauber, A Deal, CL Gong, C Hasegawa, Y Hoffman, AR Hofman, PL Horikawa, R Jorge, AAL Juul, A Kamenický, P Khadilkar, V Kopchick, JJ Kriström, B Lopes, ML Luo, X Miller, BS Misra, M Netchine Radovick, S Ranke, MB Rogol, AD Rosenfeld, RG Saenger, P Wit, JM Woelfle, J |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Collett-Solberg, PF Ambler, G Backeljauw, PF Bidlingmaier, M Biller, BMK Boguszewski, MCS Cheung, PT Choong, CSY Cohen, LE Cohen, P Dauber, A Deal, CL Gong, C Hasegawa, Y Hoffman, AR Hofman, PL Horikawa, R Jorge, AAL Juul, A Kamenický, P Khadilkar, V Kopchick, JJ Kriström, B Lopes, ML Luo, X Miller, BS Misra, M Netchine Radovick, S Ranke, MB Rogol, AD Rosenfeld, RG Saenger, P Wit, JM Woelfle, J |
dc.subject.por.fl_str_mv |
Child Humans Growth Disorders Human Growth Hormone HDE END PED |
topic |
Child Humans Growth Disorders Human Growth Hormone HDE END PED |
description |
The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2020-08-10T14:33:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3493 |
url |
http://hdl.handle.net/10400.17/3493 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Horm Res Paediatr . 2019;92(1):1-14 10.1159/000502231 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger Publishers Open Access |
publisher.none.fl_str_mv |
Karger Publishers Open Access |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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