A case of lupus podocytopathy and a review of the literature
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039 |
Resumo: | ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis. |
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A case of lupus podocytopathy and a review of the literatureAcute kidney injurynephrotic syndromepodocytesproteinuriasystemic lupus erythematosus.ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis.Sociedade Portuguesa de Nefrologia2021-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039Silvano,JoséPraça,AugustaFerreira,Inês CastroNunes,Ana TeresaRodrigues-Pereira,PedroSilva,Roberto PestanaSampaio,SusanaPestana,Manuelinfo:eu-repo/semantics/openAccess2024-02-06T17:05:09Zoai:scielo:S0872-01692021000100039Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:05.423401Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A case of lupus podocytopathy and a review of the literature |
title |
A case of lupus podocytopathy and a review of the literature |
spellingShingle |
A case of lupus podocytopathy and a review of the literature Silvano,José Acute kidney injury nephrotic syndrome podocytes proteinuria systemic lupus erythematosus. |
title_short |
A case of lupus podocytopathy and a review of the literature |
title_full |
A case of lupus podocytopathy and a review of the literature |
title_fullStr |
A case of lupus podocytopathy and a review of the literature |
title_full_unstemmed |
A case of lupus podocytopathy and a review of the literature |
title_sort |
A case of lupus podocytopathy and a review of the literature |
author |
Silvano,José |
author_facet |
Silvano,José Praça,Augusta Ferreira,Inês Castro Nunes,Ana Teresa Rodrigues-Pereira,Pedro Silva,Roberto Pestana Sampaio,Susana Pestana,Manuel |
author_role |
author |
author2 |
Praça,Augusta Ferreira,Inês Castro Nunes,Ana Teresa Rodrigues-Pereira,Pedro Silva,Roberto Pestana Sampaio,Susana Pestana,Manuel |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silvano,José Praça,Augusta Ferreira,Inês Castro Nunes,Ana Teresa Rodrigues-Pereira,Pedro Silva,Roberto Pestana Sampaio,Susana Pestana,Manuel |
dc.subject.por.fl_str_mv |
Acute kidney injury nephrotic syndrome podocytes proteinuria systemic lupus erythematosus. |
topic |
Acute kidney injury nephrotic syndrome podocytes proteinuria systemic lupus erythematosus. |
description |
ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137280756023296 |