A case of lupus podocytopathy and a review of the literature

Detalhes bibliográficos
Autor(a) principal: Silvano,José
Data de Publicação: 2021
Outros Autores: Praça,Augusta, Ferreira,Inês Castro, Nunes,Ana Teresa, Rodrigues-Pereira,Pedro, Silva,Roberto Pestana, Sampaio,Susana, Pestana,Manuel
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039
Resumo: ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis.
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spelling A case of lupus podocytopathy and a review of the literatureAcute kidney injurynephrotic syndromepodocytesproteinuriasystemic lupus erythematosus.ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis.Sociedade Portuguesa de Nefrologia2021-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000100039Silvano,JoséPraça,AugustaFerreira,Inês CastroNunes,Ana TeresaRodrigues-Pereira,PedroSilva,Roberto PestanaSampaio,SusanaPestana,Manuelinfo:eu-repo/semantics/openAccess2024-02-06T17:05:09Zoai:scielo:S0872-01692021000100039Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:05.423401Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A case of lupus podocytopathy and a review of the literature
title A case of lupus podocytopathy and a review of the literature
spellingShingle A case of lupus podocytopathy and a review of the literature
Silvano,José
Acute kidney injury
nephrotic syndrome
podocytes
proteinuria
systemic lupus erythematosus.
title_short A case of lupus podocytopathy and a review of the literature
title_full A case of lupus podocytopathy and a review of the literature
title_fullStr A case of lupus podocytopathy and a review of the literature
title_full_unstemmed A case of lupus podocytopathy and a review of the literature
title_sort A case of lupus podocytopathy and a review of the literature
author Silvano,José
author_facet Silvano,José
Praça,Augusta
Ferreira,Inês Castro
Nunes,Ana Teresa
Rodrigues-Pereira,Pedro
Silva,Roberto Pestana
Sampaio,Susana
Pestana,Manuel
author_role author
author2 Praça,Augusta
Ferreira,Inês Castro
Nunes,Ana Teresa
Rodrigues-Pereira,Pedro
Silva,Roberto Pestana
Sampaio,Susana
Pestana,Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silvano,José
Praça,Augusta
Ferreira,Inês Castro
Nunes,Ana Teresa
Rodrigues-Pereira,Pedro
Silva,Roberto Pestana
Sampaio,Susana
Pestana,Manuel
dc.subject.por.fl_str_mv Acute kidney injury
nephrotic syndrome
podocytes
proteinuria
systemic lupus erythematosus.
topic Acute kidney injury
nephrotic syndrome
podocytes
proteinuria
systemic lupus erythematosus.
description ABSTRACT Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity - lupus podocytopathy. This entity is characterized by a diffuse foot process effacement on electron microscopy and by absence of subepithelial or subendothelial immune‑complex deposition. We report the case of a 49‑year‑old woman admitted on suspicion of lupus nephritis flare, characterized by nephrotic syndrome and acute kidney injury, whose renal biopsy revealed histological features of lupus podocytopathy. Six months after discharge, under prednisolone and azathioprine, she presented 300 mg/day proteinuria, normal kidney function, without hematuria. A review of the pathogenesis, clinical features, diagnostic criteria, treatment and prognosis of lupus podocytopathy is provided. This case highlights the mounting evidence that lupus podocytopathy encompasses distinct clinical and morphological features, that should be included in the upcoming pathological classification of lupus nephritis.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-01
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.35 n.1 2021
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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