Metabolomics and Bladder Cancer: Current State and Future Perspectives
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.24915/aup.35.1-2.64 |
Resumo: | Introduction: Bladder cancer is the ninth common tumor worldwide and the most common malignant carcinoma of urinary system with an increasing incidence. Despite the high frequency and mortality associated with this carcinoma, little has evolved recently regarding the diagnosis and management of this type of tumor. In fact, cystoscopy and cytology are still standards for bladder cancer detection. The development of less invasive and more reliable diagnostic techniques of bladder cancer than cystoscopy and cytology is critical. In this sense, metabolomics has recently emerged as a promising technique for the diagnosis and orientation of oncological diseases. Evidence Acquisition: We searched PubMed, Medline and Web of Science for studies about metabolomics and bladder cancer published before October 2017. We performed a review of the literature, trying to clarify what is already known about the application of metabolomics in bladder cancer and what are the future prospects. Evidence Synthesis: The spectral acquisition is made using predominantly two analytic platforms: nuclear magnetic resonance and mass spectrometry. Regarding to bladder cancer, several metabolites were associated with the presence of bladder cancer, leading to the creation of a metabolomic profile capable of distinguishing between bladder cancer patients and control. Besides the diagnosis, the metabolomic has also been studied to stratify bladder cancer according to its aggressiveness. In this sense there are studies that used metabolomic analysis to distinguish between low-grade and high-grade bladder cancer. One investigation showed that the levels of carnitine were higher in muscle-invasive bladder cancer than in nonmuscle-invasive bladder cancer, which suggests that they may be correlated with bladder cancer aggressiveness. Conclusion: Biomarkers detected by metabolomics give an insight into cancer biology and tapped properly this can lead to new strategies for bladder cancer diagnosis and new drugs discovery. |
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Metabolomics and Bladder Cancer: Current State and Future PerspectivesMetabolómica no Carcinoma da Bexiga: Estado Atual e Perspetivas FuturasBiomarkers, TumorMetabolomeMetabolomicsUrinary Bladder NeoplasmsBiomarcadores TumoraisMetabolomaMetabolómicaNeoplasias da Bexiga UrináriaIntroduction: Bladder cancer is the ninth common tumor worldwide and the most common malignant carcinoma of urinary system with an increasing incidence. Despite the high frequency and mortality associated with this carcinoma, little has evolved recently regarding the diagnosis and management of this type of tumor. In fact, cystoscopy and cytology are still standards for bladder cancer detection. The development of less invasive and more reliable diagnostic techniques of bladder cancer than cystoscopy and cytology is critical. In this sense, metabolomics has recently emerged as a promising technique for the diagnosis and orientation of oncological diseases. Evidence Acquisition: We searched PubMed, Medline and Web of Science for studies about metabolomics and bladder cancer published before October 2017. We performed a review of the literature, trying to clarify what is already known about the application of metabolomics in bladder cancer and what are the future prospects. Evidence Synthesis: The spectral acquisition is made using predominantly two analytic platforms: nuclear magnetic resonance and mass spectrometry. Regarding to bladder cancer, several metabolites were associated with the presence of bladder cancer, leading to the creation of a metabolomic profile capable of distinguishing between bladder cancer patients and control. Besides the diagnosis, the metabolomic has also been studied to stratify bladder cancer according to its aggressiveness. In this sense there are studies that used metabolomic analysis to distinguish between low-grade and high-grade bladder cancer. One investigation showed that the levels of carnitine were higher in muscle-invasive bladder cancer than in nonmuscle-invasive bladder cancer, which suggests that they may be correlated with bladder cancer aggressiveness. Conclusion: Biomarkers detected by metabolomics give an insight into cancer biology and tapped properly this can lead to new strategies for bladder cancer diagnosis and new drugs discovery.Introdução: O carcinoma da bexiga é o nono tumor mais comum em todo o mundo e o tumor mais comum do sistema urinário com incidência crescente. Apesar da alta frequência e mortalidade associada a este tumor, pouco evoluiu recentemente quanto ao diagnóstico e tratamento desta patologia. De facto, a cistoscopia e a citologia urinária ainda são os métodos preconizados para a detecção do carcinoma da bexiga. O desenvolvimento de técnicas diagnósticas menos invasivas e mais confiáveis é fundamental. Nesse sentido, a metabolómica surgiu recentemente como uma técnica promissora para o diagnóstico e orientação de doenças oncológicas. Aquisição de Evidências: Fizemos uma pesquisa exaustiva dos estudos sobre metabolómica e carcinoma da bexiga publicados antes de Outubro de 2017, recorrendo à base bibliográfica da PubMed, Medline e Web of Science. Realizamos uma revisão da literatura, tentando esclarecer o que já é conhecido sobre a aplicação da metabolómica no carcinoma da bexiga e quais as perspectivas futuras. Síntese de Evidências: A aquisição espectral é feita usando predominantemente duas plataformas analíticas: ressonância magnética e espectrometria de massa. No que diz respeito ao carcinoma da bexiga, vários metabolitos foram associados à presença de tumor, levando à criação de um perfil metabolómico capaz de identificar os pacientes com carcinoma da bexiga. Além do diagnóstico, a metabolómica também foi estudada para estratificar os casos de carcinoma da bexiga de acordo com sua agressividade. Neste sentido, existem estudos que utilizaram a análise metabolómica para distinguir entre tumores vesicais de baixo e alto grau. Uma investigação mostrou que os níveis de carnitina foram maiores nos doentes com carcinoma da bexiga músculo-invasivo do que naqueles com tumores não invasivos, o que sugere que estes achados podem estar correlacionados com a agressividade tumoral. Conclusão: Os biomarcadores detectados pela metabolómica fornecem uma visão da biologia tumoral e usados de forma adequada poderão levar ao desenvolvimento de novas estratégias para o diagnóstico e tratamento do carcinoma da bexiga.Associação Portuguesa de Urologia2018-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.24915/aup.35.1-2.64oai:oai.actaurologicaportuguesa.com:article/64Acta Urológica Portuguesa; Vol. 35 No. 1-2 (2018): January-March; April-June; 46-51Acta Urológica Portuguesa; v. 35 n. 1-2 (2018): janeiro-março; abril-junho; 46-512387-04192341-4022reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://www.actaurologicaportuguesa.com/index.php/aup/article/view/64https://doi.org/10.24915/aup.35.1-2.64http://www.actaurologicaportuguesa.com/index.php/aup/article/view/64/36Copyright (c) 2018 Portuguese Association of Urologyinfo:eu-repo/semantics/openAccessAntunes, HugoTavares-da-SIlva, EdgarMarques, InêsCarvalho, JoãoAbrantes, Ana MargaridaAlves, MarcoBotelho, Maria FilomenaFigueiredo, Arnaldo2022-09-21T09:04:46Zoai:oai.actaurologicaportuguesa.com:article/64Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:53.473127Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metabolomics and Bladder Cancer: Current State and Future Perspectives Metabolómica no Carcinoma da Bexiga: Estado Atual e Perspetivas Futuras |
title |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
spellingShingle |
Metabolomics and Bladder Cancer: Current State and Future Perspectives Antunes, Hugo Biomarkers, Tumor Metabolome Metabolomics Urinary Bladder Neoplasms Biomarcadores Tumorais Metaboloma Metabolómica Neoplasias da Bexiga Urinária |
title_short |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
title_full |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
title_fullStr |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
title_full_unstemmed |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
title_sort |
Metabolomics and Bladder Cancer: Current State and Future Perspectives |
author |
Antunes, Hugo |
author_facet |
Antunes, Hugo Tavares-da-SIlva, Edgar Marques, Inês Carvalho, João Abrantes, Ana Margarida Alves, Marco Botelho, Maria Filomena Figueiredo, Arnaldo |
author_role |
author |
author2 |
Tavares-da-SIlva, Edgar Marques, Inês Carvalho, João Abrantes, Ana Margarida Alves, Marco Botelho, Maria Filomena Figueiredo, Arnaldo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes, Hugo Tavares-da-SIlva, Edgar Marques, Inês Carvalho, João Abrantes, Ana Margarida Alves, Marco Botelho, Maria Filomena Figueiredo, Arnaldo |
dc.subject.por.fl_str_mv |
Biomarkers, Tumor Metabolome Metabolomics Urinary Bladder Neoplasms Biomarcadores Tumorais Metaboloma Metabolómica Neoplasias da Bexiga Urinária |
topic |
Biomarkers, Tumor Metabolome Metabolomics Urinary Bladder Neoplasms Biomarcadores Tumorais Metaboloma Metabolómica Neoplasias da Bexiga Urinária |
description |
Introduction: Bladder cancer is the ninth common tumor worldwide and the most common malignant carcinoma of urinary system with an increasing incidence. Despite the high frequency and mortality associated with this carcinoma, little has evolved recently regarding the diagnosis and management of this type of tumor. In fact, cystoscopy and cytology are still standards for bladder cancer detection. The development of less invasive and more reliable diagnostic techniques of bladder cancer than cystoscopy and cytology is critical. In this sense, metabolomics has recently emerged as a promising technique for the diagnosis and orientation of oncological diseases. Evidence Acquisition: We searched PubMed, Medline and Web of Science for studies about metabolomics and bladder cancer published before October 2017. We performed a review of the literature, trying to clarify what is already known about the application of metabolomics in bladder cancer and what are the future prospects. Evidence Synthesis: The spectral acquisition is made using predominantly two analytic platforms: nuclear magnetic resonance and mass spectrometry. Regarding to bladder cancer, several metabolites were associated with the presence of bladder cancer, leading to the creation of a metabolomic profile capable of distinguishing between bladder cancer patients and control. Besides the diagnosis, the metabolomic has also been studied to stratify bladder cancer according to its aggressiveness. In this sense there are studies that used metabolomic analysis to distinguish between low-grade and high-grade bladder cancer. One investigation showed that the levels of carnitine were higher in muscle-invasive bladder cancer than in nonmuscle-invasive bladder cancer, which suggests that they may be correlated with bladder cancer aggressiveness. Conclusion: Biomarkers detected by metabolomics give an insight into cancer biology and tapped properly this can lead to new strategies for bladder cancer diagnosis and new drugs discovery. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-25T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.24915/aup.35.1-2.64 oai:oai.actaurologicaportuguesa.com:article/64 |
url |
https://doi.org/10.24915/aup.35.1-2.64 |
identifier_str_mv |
oai:oai.actaurologicaportuguesa.com:article/64 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.actaurologicaportuguesa.com/index.php/aup/article/view/64 https://doi.org/10.24915/aup.35.1-2.64 http://www.actaurologicaportuguesa.com/index.php/aup/article/view/64/36 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Portuguese Association of Urology info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Portuguese Association of Urology |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Associação Portuguesa de Urologia |
publisher.none.fl_str_mv |
Associação Portuguesa de Urologia |
dc.source.none.fl_str_mv |
Acta Urológica Portuguesa; Vol. 35 No. 1-2 (2018): January-March; April-June; 46-51 Acta Urológica Portuguesa; v. 35 n. 1-2 (2018): janeiro-março; abril-junho; 46-51 2387-0419 2341-4022 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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