Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36267 |
Resumo: | The emergence of biopharmaceuticals, including proteins, nucleic acids, peptides, and vaccines, revolutionized the medical field, contributing to significant advances in the prophylaxis and treatment of chronic and life-threatening diseases. However, biopharmaceuticals manufacturing involves a set of complex upstream and downstream processes, which considerably impact their cost. In particular, despite the efforts made in the last decades to improve the existing technologies, downstream processing still accounts for more than 80% of the total biopharmaceutical production cost. On the other hand, the formulation of biological products must ensure they maintain their therapeutic performance and long-term stability, while preserving their physical and chemical structure. Ionicliquid (IL)-based approaches arose as a promise alternative, showing the potential to be used in downstream processing to provide increased purity and recovery yield, as well as excipients for the development of stable biopharmaceutical formulations. This manuscript reviews the most important progress achieved in both fields. The work developed is critically discussed and complemented with a SWOT analysis. |
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Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulationBiopharmaceuticalsIonic liquidsBiomanufacturingDownstream processingPurification platformsFormulationIonic liquid-based approachesBiopharmaceuticals administrationThe emergence of biopharmaceuticals, including proteins, nucleic acids, peptides, and vaccines, revolutionized the medical field, contributing to significant advances in the prophylaxis and treatment of chronic and life-threatening diseases. However, biopharmaceuticals manufacturing involves a set of complex upstream and downstream processes, which considerably impact their cost. In particular, despite the efforts made in the last decades to improve the existing technologies, downstream processing still accounts for more than 80% of the total biopharmaceutical production cost. On the other hand, the formulation of biological products must ensure they maintain their therapeutic performance and long-term stability, while preserving their physical and chemical structure. Ionicliquid (IL)-based approaches arose as a promise alternative, showing the potential to be used in downstream processing to provide increased purity and recovery yield, as well as excipients for the development of stable biopharmaceutical formulations. This manuscript reviews the most important progress achieved in both fields. The work developed is critically discussed and complemented with a SWOT analysis.Frontiers Media2023-02-09T10:01:35Z2023-01-01T00:00:00Z2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/36267eng10.3389/fbioe.2023.1037436Almeida, CatarinaPedro, Augusto Q.Tavares, Ana P. M.Neves, Márcia C.Freire, Mara G.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-17T04:17:47ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
title |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
spellingShingle |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation Almeida, Catarina Biopharmaceuticals Ionic liquids Biomanufacturing Downstream processing Purification platforms Formulation Ionic liquid-based approaches Biopharmaceuticals administration |
title_short |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
title_full |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
title_fullStr |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
title_full_unstemmed |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
title_sort |
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation |
author |
Almeida, Catarina |
author_facet |
Almeida, Catarina Pedro, Augusto Q. Tavares, Ana P. M. Neves, Márcia C. Freire, Mara G. |
author_role |
author |
author2 |
Pedro, Augusto Q. Tavares, Ana P. M. Neves, Márcia C. Freire, Mara G. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Catarina Pedro, Augusto Q. Tavares, Ana P. M. Neves, Márcia C. Freire, Mara G. |
dc.subject.por.fl_str_mv |
Biopharmaceuticals Ionic liquids Biomanufacturing Downstream processing Purification platforms Formulation Ionic liquid-based approaches Biopharmaceuticals administration |
topic |
Biopharmaceuticals Ionic liquids Biomanufacturing Downstream processing Purification platforms Formulation Ionic liquid-based approaches Biopharmaceuticals administration |
description |
The emergence of biopharmaceuticals, including proteins, nucleic acids, peptides, and vaccines, revolutionized the medical field, contributing to significant advances in the prophylaxis and treatment of chronic and life-threatening diseases. However, biopharmaceuticals manufacturing involves a set of complex upstream and downstream processes, which considerably impact their cost. In particular, despite the efforts made in the last decades to improve the existing technologies, downstream processing still accounts for more than 80% of the total biopharmaceutical production cost. On the other hand, the formulation of biological products must ensure they maintain their therapeutic performance and long-term stability, while preserving their physical and chemical structure. Ionicliquid (IL)-based approaches arose as a promise alternative, showing the potential to be used in downstream processing to provide increased purity and recovery yield, as well as excipients for the development of stable biopharmaceutical formulations. This manuscript reviews the most important progress achieved in both fields. The work developed is critically discussed and complemented with a SWOT analysis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-09T10:01:35Z 2023-01-01T00:00:00Z 2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36267 |
url |
http://hdl.handle.net/10773/36267 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3389/fbioe.2023.1037436 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303593366323200 |