Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression
Main Author: | |
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Publication Date: | 2021 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | https://hdl.handle.net/10216/155599 |
Summary: | Arginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. This review presents evidence concerning the impact of arginine metabolism and arginase activity in the prostate cancer microenvironment, highlighting the recent advances in immunotherapy, which might be relevant for prostate cancer. Even though further research is required, arginine deprivation may represent a novel antimetabolite strategy for the treatment of arginine-dependent prostate cancer. |
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Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progressionArginaseArginineMetabolismNitric oxideProstate cancerTumor microenvironmentArginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. This review presents evidence concerning the impact of arginine metabolism and arginase activity in the prostate cancer microenvironment, highlighting the recent advances in immunotherapy, which might be relevant for prostate cancer. Even though further research is required, arginine deprivation may represent a novel antimetabolite strategy for the treatment of arginine-dependent prostate cancer.MDPI20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/155599eng2072-664310.3390/nu13124503Matos, MCarvalho, MBicho, MRibeiro, Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-16T06:03:15Zoai:repositorio-aberto.up.pt:10216/155599Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:54:32.971759Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
title |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
spellingShingle |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression Matos, M Arginase Arginine Metabolism Nitric oxide Prostate cancer Tumor microenvironment |
title_short |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
title_full |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
title_fullStr |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
title_full_unstemmed |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
title_sort |
Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression |
author |
Matos, M |
author_facet |
Matos, M Carvalho, M Bicho, M Ribeiro, R |
author_role |
author |
author2 |
Carvalho, M Bicho, M Ribeiro, R |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Matos, M Carvalho, M Bicho, M Ribeiro, R |
dc.subject.por.fl_str_mv |
Arginase Arginine Metabolism Nitric oxide Prostate cancer Tumor microenvironment |
topic |
Arginase Arginine Metabolism Nitric oxide Prostate cancer Tumor microenvironment |
description |
Arginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. This review presents evidence concerning the impact of arginine metabolism and arginase activity in the prostate cancer microenvironment, highlighting the recent advances in immunotherapy, which might be relevant for prostate cancer. Even though further research is required, arginine deprivation may represent a novel antimetabolite strategy for the treatment of arginine-dependent prostate cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/155599 |
url |
https://hdl.handle.net/10216/155599 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2072-6643 10.3390/nu13124503 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136433102913537 |