DisProt: Intrinsic protein disorder annotation in 2020
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/141442 |
Resumo: | The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome. |
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spelling |
DisProt: Intrinsic protein disorder annotation in 2020The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome.Oxford University Press20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/141442eng0305-104810.1093/nar/gkz975Hatos, AHajdu-Soltész, BMonzon, AMPalopoli, NÁlvarez, LAykac-Fas, BBassot, CBenítez, GIBevilacqua, MChasapi, AChemes, LDavey, NEDavidovic, RDunker, AKElofsson, AGobeill, JFoutel, NSGSudha, GGuharoy, MHorvath, TIglesias, VKajava, AVKovacs, OPLamb, JLambrughi, MLazar, TLeclercq, JYLeonardi, EMacedo-Ribeiro, SMacOssay-Castillo, MMaiani, EManso, JAMarino-Buslje, CMartínez-Pérez, EMészáros, BMicetic, IMinervini, GMurvai, NNecci, MOuzounis, CAPajkos, MPaladin, LPancsa, RPapaleo, EParisi, GPasche, EBarbosa Pereira, PJPromponas, VJPujols, JQuaglia, FRuch, PSalvatore, MSchad, ESzabo, BSzaniszló, TTamana, STantos, AVeljkovic, NVentura, SVranken, WDosztányi, ZTompa, PTosatto, SCEPiovesan, Dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:58:05Zoai:repositorio-aberto.up.pt:10216/141442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:30:39.606841Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
DisProt: Intrinsic protein disorder annotation in 2020 |
title |
DisProt: Intrinsic protein disorder annotation in 2020 |
spellingShingle |
DisProt: Intrinsic protein disorder annotation in 2020 Hatos, A |
title_short |
DisProt: Intrinsic protein disorder annotation in 2020 |
title_full |
DisProt: Intrinsic protein disorder annotation in 2020 |
title_fullStr |
DisProt: Intrinsic protein disorder annotation in 2020 |
title_full_unstemmed |
DisProt: Intrinsic protein disorder annotation in 2020 |
title_sort |
DisProt: Intrinsic protein disorder annotation in 2020 |
author |
Hatos, A |
author_facet |
Hatos, A Hajdu-Soltész, B Monzon, AM Palopoli, N Álvarez, L Aykac-Fas, B Bassot, C Benítez, GI Bevilacqua, M Chasapi, A Chemes, L Davey, NE Davidovic, R Dunker, AK Elofsson, A Gobeill, J Foutel, NSG Sudha, G Guharoy, M Horvath, T Iglesias, V Kajava, AV Kovacs, OP Lamb, J Lambrughi, M Lazar, T Leclercq, JY Leonardi, E Macedo-Ribeiro, S MacOssay-Castillo, M Maiani, E Manso, JA Marino-Buslje, C Martínez-Pérez, E Mészáros, B Micetic, I Minervini, G Murvai, N Necci, M Ouzounis, CA Pajkos, M Paladin, L Pancsa, R Papaleo, E Parisi, G Pasche, E Barbosa Pereira, PJ Promponas, VJ Pujols, J Quaglia, F Ruch, P Salvatore, M Schad, E Szabo, B Szaniszló, T Tamana, S Tantos, A Veljkovic, N Ventura, S Vranken, W Dosztányi, Z Tompa, P Tosatto, SCE Piovesan, D |
author_role |
author |
author2 |
Hajdu-Soltész, B Monzon, AM Palopoli, N Álvarez, L Aykac-Fas, B Bassot, C Benítez, GI Bevilacqua, M Chasapi, A Chemes, L Davey, NE Davidovic, R Dunker, AK Elofsson, A Gobeill, J Foutel, NSG Sudha, G Guharoy, M Horvath, T Iglesias, V Kajava, AV Kovacs, OP Lamb, J Lambrughi, M Lazar, T Leclercq, JY Leonardi, E Macedo-Ribeiro, S MacOssay-Castillo, M Maiani, E Manso, JA Marino-Buslje, C Martínez-Pérez, E Mészáros, B Micetic, I Minervini, G Murvai, N Necci, M Ouzounis, CA Pajkos, M Paladin, L Pancsa, R Papaleo, E Parisi, G Pasche, E Barbosa Pereira, PJ Promponas, VJ Pujols, J Quaglia, F Ruch, P Salvatore, M Schad, E Szabo, B Szaniszló, T Tamana, S Tantos, A Veljkovic, N Ventura, S Vranken, W Dosztányi, Z Tompa, P Tosatto, SCE Piovesan, D |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hatos, A Hajdu-Soltész, B Monzon, AM Palopoli, N Álvarez, L Aykac-Fas, B Bassot, C Benítez, GI Bevilacqua, M Chasapi, A Chemes, L Davey, NE Davidovic, R Dunker, AK Elofsson, A Gobeill, J Foutel, NSG Sudha, G Guharoy, M Horvath, T Iglesias, V Kajava, AV Kovacs, OP Lamb, J Lambrughi, M Lazar, T Leclercq, JY Leonardi, E Macedo-Ribeiro, S MacOssay-Castillo, M Maiani, E Manso, JA Marino-Buslje, C Martínez-Pérez, E Mészáros, B Micetic, I Minervini, G Murvai, N Necci, M Ouzounis, CA Pajkos, M Paladin, L Pancsa, R Papaleo, E Parisi, G Pasche, E Barbosa Pereira, PJ Promponas, VJ Pujols, J Quaglia, F Ruch, P Salvatore, M Schad, E Szabo, B Szaniszló, T Tamana, S Tantos, A Veljkovic, N Ventura, S Vranken, W Dosztányi, Z Tompa, P Tosatto, SCE Piovesan, D |
description |
The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/141442 |
url |
https://hdl.handle.net/10216/141442 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0305-1048 10.1093/nar/gkz975 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135615107727360 |