Ionic liquids in drug delivery

Detalhes bibliográficos
Autor(a) principal: Pedro, Sónia N.
Data de Publicação: 2021
Outros Autores: Freire, Carmen S. R., Silvestre, Armando J. D., Freire, Mara G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/34486
Resumo: Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.
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spelling Ionic liquids in drug deliveryActive pharmaceutical ingredientsDrug deliveryFormulationsIonic liquidsPermeation enhancersStimuli-responsive systemsIonic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.MDPI2022-08-30T16:24:02Z2021-04-01T00:00:00Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34486eng10.3390/encyclopedia1020027Pedro, Sónia N.Freire, Carmen S. R.Silvestre, Armando J. D.Freire, Mara G.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:49Zoai:ria.ua.pt:10773/34486Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:52.655614Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ionic liquids in drug delivery
title Ionic liquids in drug delivery
spellingShingle Ionic liquids in drug delivery
Pedro, Sónia N.
Active pharmaceutical ingredients
Drug delivery
Formulations
Ionic liquids
Permeation enhancers
Stimuli-responsive systems
title_short Ionic liquids in drug delivery
title_full Ionic liquids in drug delivery
title_fullStr Ionic liquids in drug delivery
title_full_unstemmed Ionic liquids in drug delivery
title_sort Ionic liquids in drug delivery
author Pedro, Sónia N.
author_facet Pedro, Sónia N.
Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
author_role author
author2 Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Pedro, Sónia N.
Freire, Carmen S. R.
Silvestre, Armando J. D.
Freire, Mara G.
dc.subject.por.fl_str_mv Active pharmaceutical ingredients
Drug delivery
Formulations
Ionic liquids
Permeation enhancers
Stimuli-responsive systems
topic Active pharmaceutical ingredients
Drug delivery
Formulations
Ionic liquids
Permeation enhancers
Stimuli-responsive systems
description Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-01T00:00:00Z
2021-04-01
2022-08-30T16:24:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/34486
url http://hdl.handle.net/10773/34486
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/encyclopedia1020027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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