Propolis: a potential natural product to fight Candida species infections

Detalhes bibliográficos
Autor(a) principal: Tobaldini-Valerio, Flávia
Data de Publicação: 2016
Outros Autores: Bonfim-Mendonça, P. S., Rosseto, H. C., Bruschi, M. L., Henriques, Mariana, Negri, Melyssa, Silva, Sónia Carina, Svidzinski, Terezinha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/44740
Resumo: Aim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation. Conclusion: Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.
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spelling Propolis: a potential natural product to fight Candida species infectionsCandida speciesBiofilmPropolis extractVirulence factorsScience & TechnologyAim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation. Conclusion: Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.The authors thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Cnpq) and Fundação Araucária for the financial support received. Flávia Tobaldini-Valerio acknowledges the financial support of CAPES – Proc. 9469/14-1. The authors also thank FCT for the Strategic Project of the UID/BIO/04469/2013 unit, FCT and European Union funds (FEDER/COMPETE) for the project RECI/BBBEBI/0179/2012 (FCOMP-01-0124-FEDER-027462). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Future MedicineUniversidade do MinhoTobaldini-Valerio, FláviaBonfim-Mendonça, P. S.Rosseto, H. C.Bruschi, M. L.Henriques, MarianaNegri, MelyssaSilva, Sónia CarinaSvidzinski, Terezinha2016-082016-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/44740engTobaldini-Valerio, Flávia; Bonfim-Mendonça, Patricia S.; Rosseto, Helen C.; Bruschi, Marcos L.; Henriques, Mariana; Negri, Melyssa; Silva, Sónia Carina; Svidzinski, Terezinha I. E., Propolis: a potential natural product to fight Candida species infections. Future Microbiology, 11(8), 1035-1046, 20161746-09131746-092110.2217/fmb-2015-001627501739http://www.futuremedicine.com/loi/fmbinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:45Zoai:repositorium.sdum.uminho.pt:1822/44740Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:55.933780Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Propolis: a potential natural product to fight Candida species infections
title Propolis: a potential natural product to fight Candida species infections
spellingShingle Propolis: a potential natural product to fight Candida species infections
Tobaldini-Valerio, Flávia
Candida species
Biofilm
Propolis extract
Virulence factors
Science & Technology
title_short Propolis: a potential natural product to fight Candida species infections
title_full Propolis: a potential natural product to fight Candida species infections
title_fullStr Propolis: a potential natural product to fight Candida species infections
title_full_unstemmed Propolis: a potential natural product to fight Candida species infections
title_sort Propolis: a potential natural product to fight Candida species infections
author Tobaldini-Valerio, Flávia
author_facet Tobaldini-Valerio, Flávia
Bonfim-Mendonça, P. S.
Rosseto, H. C.
Bruschi, M. L.
Henriques, Mariana
Negri, Melyssa
Silva, Sónia Carina
Svidzinski, Terezinha
author_role author
author2 Bonfim-Mendonça, P. S.
Rosseto, H. C.
Bruschi, M. L.
Henriques, Mariana
Negri, Melyssa
Silva, Sónia Carina
Svidzinski, Terezinha
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Tobaldini-Valerio, Flávia
Bonfim-Mendonça, P. S.
Rosseto, H. C.
Bruschi, M. L.
Henriques, Mariana
Negri, Melyssa
Silva, Sónia Carina
Svidzinski, Terezinha
dc.subject.por.fl_str_mv Candida species
Biofilm
Propolis extract
Virulence factors
Science & Technology
topic Candida species
Biofilm
Propolis extract
Virulence factors
Science & Technology
description Aim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 µg/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation. Conclusion: Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
2016-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/44740
url http://hdl.handle.net/1822/44740
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tobaldini-Valerio, Flávia; Bonfim-Mendonça, Patricia S.; Rosseto, Helen C.; Bruschi, Marcos L.; Henriques, Mariana; Negri, Melyssa; Silva, Sónia Carina; Svidzinski, Terezinha I. E., Propolis: a potential natural product to fight Candida species infections. Future Microbiology, 11(8), 1035-1046, 2016
1746-0913
1746-0921
10.2217/fmb-2015-0016
27501739
http://www.futuremedicine.com/loi/fmb
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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