Antiangiogenic compounds: well-established drugs versus emerging natural molecules
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/15041 |
Resumo: | Angiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed. |
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Antiangiogenic compounds: well-established drugs versus emerging natural moleculesAngiogenesisMolecular targetsSynthetic drugsNatural compoundsAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.POCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by FEDER, through POCI-COMPETE2020 and FCT; Project NORTE-01-0145- FEDER-000006, funded by NORTE2020 under the PT2020, through ERDF; FCT and ERDF under PT2020 for financial support to CIMO (UID/AGR/00690/2013). Andreia Ribeiro acknowledges her PhD fellowship funded by Project NORTE-08-5369-FSE-000028, supported by N2020, under PT2020, through ESF.Biblioteca Digital do IPBRibeiro, AndreiaAbreu, Rui M.V.Dias, Madalena M.Barreiro, M.F.Ferreira, Isabel C.F.R.2018-01-29T10:00:00Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15041engRibeiro, Andreia; Abreu, Rui M.V.; Dias, Madalena M.; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2018). Antiangiogenic compounds: well-established drugs versus emerging natural molecules. Cancer Letters. ISSN 0304-3835. 415. p. 86-1050304-383510.1016/j.canlet.2017.12.006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:35:31Zoai:bibliotecadigital.ipb.pt:10198/15041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:04:50.587948Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
title |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
spellingShingle |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules Ribeiro, Andreia Angiogenesis Molecular targets Synthetic drugs Natural compounds |
title_short |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
title_full |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
title_fullStr |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
title_full_unstemmed |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
title_sort |
Antiangiogenic compounds: well-established drugs versus emerging natural molecules |
author |
Ribeiro, Andreia |
author_facet |
Ribeiro, Andreia Abreu, Rui M.V. Dias, Madalena M. Barreiro, M.F. Ferreira, Isabel C.F.R. |
author_role |
author |
author2 |
Abreu, Rui M.V. Dias, Madalena M. Barreiro, M.F. Ferreira, Isabel C.F.R. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Ribeiro, Andreia Abreu, Rui M.V. Dias, Madalena M. Barreiro, M.F. Ferreira, Isabel C.F.R. |
dc.subject.por.fl_str_mv |
Angiogenesis Molecular targets Synthetic drugs Natural compounds |
topic |
Angiogenesis Molecular targets Synthetic drugs Natural compounds |
description |
Angiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-29T10:00:00Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/15041 |
url |
http://hdl.handle.net/10198/15041 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ribeiro, Andreia; Abreu, Rui M.V.; Dias, Madalena M.; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2018). Antiangiogenic compounds: well-established drugs versus emerging natural molecules. Cancer Letters. ISSN 0304-3835. 415. p. 86-105 0304-3835 10.1016/j.canlet.2017.12.006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135296667779072 |