Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT)
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36782 |
Resumo: | Neutron capture therapy (NCT) is a form of radiotherapy that exploits the potential of some specific isotopes to capture thermal neutrons and subsequently yield high linear energy transfer (LET) particles, suitable for cancer treatment. Recently, relevant technological improvements have been made in terms of accelerators as suitable neutron sources for NCT at hospitals. However, low selective delivery of current drugs to cancer cells remains as the main challenge for successful clinical application of NCT. This work presents an innovative and previously unexplored approach for the design of nanotherapeutic NCT agents. Herein, a new concept based on carbon nanomaterials that seal 6Li active NCT nuclides is investigated. The 6Li active species are located in the inner cavity of the nanocarrier (carbon nanohorns or carbon nanotubes) and therefore, completely protected from the biological environment, avoiding toxicity and degradation. After encapsulation of the active cargo, the external surface of the nanocarrier is modified for improved biocompatibility. The developed 6Li-filled carbon nanohorns offered the possibility to explore 6Li compounds as active NCT agents by delivering therapeutic doses to cancer cells. We envisage that nanoencapsulation of 6Li can trigger the successful development and implementation of Lithium Neutron Cancer Therapy (LiNCT). |
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Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT)Lithium-6Enriched lithium 6LiCarbon nanohornsShort multiwall carbon nanotubesCancer RadiotherapyNanooncologyNeutron capture therapy (NCT) is a form of radiotherapy that exploits the potential of some specific isotopes to capture thermal neutrons and subsequently yield high linear energy transfer (LET) particles, suitable for cancer treatment. Recently, relevant technological improvements have been made in terms of accelerators as suitable neutron sources for NCT at hospitals. However, low selective delivery of current drugs to cancer cells remains as the main challenge for successful clinical application of NCT. This work presents an innovative and previously unexplored approach for the design of nanotherapeutic NCT agents. Herein, a new concept based on carbon nanomaterials that seal 6Li active NCT nuclides is investigated. The 6Li active species are located in the inner cavity of the nanocarrier (carbon nanohorns or carbon nanotubes) and therefore, completely protected from the biological environment, avoiding toxicity and degradation. After encapsulation of the active cargo, the external surface of the nanocarrier is modified for improved biocompatibility. The developed 6Li-filled carbon nanohorns offered the possibility to explore 6Li compounds as active NCT agents by delivering therapeutic doses to cancer cells. We envisage that nanoencapsulation of 6Li can trigger the successful development and implementation of Lithium Neutron Cancer Therapy (LiNCT).Elsevier2025-03-13T00:00:00Z2023-03-13T00:00:00Z2023-03-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttp://hdl.handle.net/10773/36782eng0008-622310.1016/j.carbon.2023.03.034Gonçalves, GilSandoval, StefaniaLlenas, MarinaBallesteros, BelénDa Ros, TatianaBortolussi, SilvaCansolino, LauraFerrari, CinziaPostuma, IanProtti, NicolettaMelle-Franco, ManuelAltieri, SaverioTobías-Rossell, Gerardinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:10:50Zoai:ria.ua.pt:10773/36782Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:27.412261Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
title |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
spellingShingle |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) Gonçalves, Gil Lithium-6 Enriched lithium 6Li Carbon nanohorns Short multiwall carbon nanotubes Cancer Radiotherapy Nanooncology |
title_short |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
title_full |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
title_fullStr |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
title_full_unstemmed |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
title_sort |
Lithium halide filled carbon nanocapsules: paving the way towards lithium neutron capture therapy (LiNCT) |
author |
Gonçalves, Gil |
author_facet |
Gonçalves, Gil Sandoval, Stefania Llenas, Marina Ballesteros, Belén Da Ros, Tatiana Bortolussi, Silva Cansolino, Laura Ferrari, Cinzia Postuma, Ian Protti, Nicoletta Melle-Franco, Manuel Altieri, Saverio Tobías-Rossell, Gerard |
author_role |
author |
author2 |
Sandoval, Stefania Llenas, Marina Ballesteros, Belén Da Ros, Tatiana Bortolussi, Silva Cansolino, Laura Ferrari, Cinzia Postuma, Ian Protti, Nicoletta Melle-Franco, Manuel Altieri, Saverio Tobías-Rossell, Gerard |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gonçalves, Gil Sandoval, Stefania Llenas, Marina Ballesteros, Belén Da Ros, Tatiana Bortolussi, Silva Cansolino, Laura Ferrari, Cinzia Postuma, Ian Protti, Nicoletta Melle-Franco, Manuel Altieri, Saverio Tobías-Rossell, Gerard |
dc.subject.por.fl_str_mv |
Lithium-6 Enriched lithium 6Li Carbon nanohorns Short multiwall carbon nanotubes Cancer Radiotherapy Nanooncology |
topic |
Lithium-6 Enriched lithium 6Li Carbon nanohorns Short multiwall carbon nanotubes Cancer Radiotherapy Nanooncology |
description |
Neutron capture therapy (NCT) is a form of radiotherapy that exploits the potential of some specific isotopes to capture thermal neutrons and subsequently yield high linear energy transfer (LET) particles, suitable for cancer treatment. Recently, relevant technological improvements have been made in terms of accelerators as suitable neutron sources for NCT at hospitals. However, low selective delivery of current drugs to cancer cells remains as the main challenge for successful clinical application of NCT. This work presents an innovative and previously unexplored approach for the design of nanotherapeutic NCT agents. Herein, a new concept based on carbon nanomaterials that seal 6Li active NCT nuclides is investigated. The 6Li active species are located in the inner cavity of the nanocarrier (carbon nanohorns or carbon nanotubes) and therefore, completely protected from the biological environment, avoiding toxicity and degradation. After encapsulation of the active cargo, the external surface of the nanocarrier is modified for improved biocompatibility. The developed 6Li-filled carbon nanohorns offered the possibility to explore 6Li compounds as active NCT agents by delivering therapeutic doses to cancer cells. We envisage that nanoencapsulation of 6Li can trigger the successful development and implementation of Lithium Neutron Cancer Therapy (LiNCT). |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-13T00:00:00Z 2023-03-13 2025-03-13T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36782 |
url |
http://hdl.handle.net/10773/36782 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0008-6223 10.1016/j.carbon.2023.03.034 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/vnd.openxmlformats-officedocument.wordprocessingml.document |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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