High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats

Detalhes bibliográficos
Autor(a) principal: Paulo, Sara L
Data de Publicação: 2021
Outros Autores: Miranda-Lourenço, Catarina, Belo, Rita F., Rodrigues, Rui S., Fonseca-Gomes, João, Tanqueiro, Sara, Geraldes, Vera, Rocha, Isabel, Sebastião, Ana M, Xapelli, Sara, Diógenes, Maria José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50686
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged ratsAgingBrain-derived neurotrophic factor (BDNF)High caloric dietHippocampal plasticityMemoryNeurogenesisObesity© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The increasing consumption of sugar and fat seen over the last decades and the consequent overweight and obesity, were recently linked with a deleterious effect on cognition and synaptic function. A major question, which remains to be clarified, is whether obesity in the elderly is an additional risk factor for cognitive impairment. We aimed at unravelling the impact of a chronic high caloric diet (HCD) on memory performance and synaptic plasticity in aged rats. Male rats were kept on an HCD or a standard diet (control) from 1 to 24 months of age. The results showed that under an HCD, aged rats were obese and displayed significant long-term recognition memory impairment when compared to age-matched controls. Ex vivo synaptic plasticity recorded from hippocampal slices from HCD-fed aged rats revealed a reduction in the magnitude of long-term potentiation, accompanied by a decrease in the levels of the brain-derived neurotrophic factor receptors TrkB full-length (TrkB-FL). No alterations in neurogenesis were observed, as quantified by the density of immature doublecortin-positive neurons in the hippocampal dentate gyrus. This study highlights that obesity induced by a chronic HCD exacerbates age-associated cognitive decline, likely due to impaired synaptic plasticity, which might be associated with deficits in TrkB-FL signaling.This research was funded by Santa Casa da Misericórdia de Lisboa—MB37-2017; Fundação para a Ciência e a Tecnologia (FCT)—IF/01227/2015; and it received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 952455. Researchers were supported by the following: S.L.P.—FCT (PD/BD/150341/2019); C.M.-L.—FCT (SFRH/BD/118238/2016) and Universidade de Lisboa (BD2015); R.F.B.—FCT (PD/BD/114337/2016); R.S.R.—FCT (SFRH/BD/129710/2017); S.R.T.—FCT (SFRH/BD/128091/2016).MDPIRepositório da Universidade de LisboaPaulo, Sara LMiranda-Lourenço, CatarinaBelo, Rita F.Rodrigues, Rui S.Fonseca-Gomes, JoãoTanqueiro, SaraGeraldes, VeraRocha, IsabelSebastião, Ana MXapelli, SaraDiógenes, Maria José2022-01-04T13:43:02Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50686engCurr Issues Mol Biol. 2021 Dec 18;43(3):2305-23191467-303710.3390/cimb430301621467-3045info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:52Zoai:repositorio.ul.pt:10451/50686Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:01.379934Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
title High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
spellingShingle High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
Paulo, Sara L
Aging
Brain-derived neurotrophic factor (BDNF)
High caloric diet
Hippocampal plasticity
Memory
Neurogenesis
Obesity
title_short High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
title_full High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
title_fullStr High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
title_full_unstemmed High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
title_sort High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats
author Paulo, Sara L
author_facet Paulo, Sara L
Miranda-Lourenço, Catarina
Belo, Rita F.
Rodrigues, Rui S.
Fonseca-Gomes, João
Tanqueiro, Sara
Geraldes, Vera
Rocha, Isabel
Sebastião, Ana M
Xapelli, Sara
Diógenes, Maria José
author_role author
author2 Miranda-Lourenço, Catarina
Belo, Rita F.
Rodrigues, Rui S.
Fonseca-Gomes, João
Tanqueiro, Sara
Geraldes, Vera
Rocha, Isabel
Sebastião, Ana M
Xapelli, Sara
Diógenes, Maria José
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Paulo, Sara L
Miranda-Lourenço, Catarina
Belo, Rita F.
Rodrigues, Rui S.
Fonseca-Gomes, João
Tanqueiro, Sara
Geraldes, Vera
Rocha, Isabel
Sebastião, Ana M
Xapelli, Sara
Diógenes, Maria José
dc.subject.por.fl_str_mv Aging
Brain-derived neurotrophic factor (BDNF)
High caloric diet
Hippocampal plasticity
Memory
Neurogenesis
Obesity
topic Aging
Brain-derived neurotrophic factor (BDNF)
High caloric diet
Hippocampal plasticity
Memory
Neurogenesis
Obesity
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-01-04T13:43:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50686
url http://hdl.handle.net/10451/50686
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Curr Issues Mol Biol. 2021 Dec 18;43(3):2305-2319
1467-3037
10.3390/cimb43030162
1467-3045
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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