Transthyretin is involved in depression-like behaviour and exploratory activity
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/1657 |
Resumo: | Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system. |
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Transthyretin is involved in depression-like behaviour and exploratory activityBehaviourRetinoidsNorepinephrineThyroid hormoneThyroxineTransthyretinScience & TechnologyTransthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system.Fundação para a Ciência e a Tecnologia (FCT) - Programa Operacional "Ciência, Tecnologia, Inovação" POCTI/NSE/37315/2001.WileyUniversidade do MinhoSousa, João CarlosGrandela, CatarinaFernández-Ruiz, JavierMiguel, Rosário deSousa, Liliana deMagalhães, Ana IsabelSaraiva, Maria JoãoSousa, NunoPalha, Joana Almeida20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/1657eng"Journal of neurochemistry". ISSN 0022-3042. 88 (2004) 1052–1058.0022-304210.1046/j.1471-4159.2003.02309.x15009661info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:34ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Transthyretin is involved in depression-like behaviour and exploratory activity |
title |
Transthyretin is involved in depression-like behaviour and exploratory activity |
spellingShingle |
Transthyretin is involved in depression-like behaviour and exploratory activity Sousa, João Carlos Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin Science & Technology |
title_short |
Transthyretin is involved in depression-like behaviour and exploratory activity |
title_full |
Transthyretin is involved in depression-like behaviour and exploratory activity |
title_fullStr |
Transthyretin is involved in depression-like behaviour and exploratory activity |
title_full_unstemmed |
Transthyretin is involved in depression-like behaviour and exploratory activity |
title_sort |
Transthyretin is involved in depression-like behaviour and exploratory activity |
author |
Sousa, João Carlos |
author_facet |
Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
author_role |
author |
author2 |
Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sousa, João Carlos Grandela, Catarina Fernández-Ruiz, Javier Miguel, Rosário de Sousa, Liliana de Magalhães, Ana Isabel Saraiva, Maria João Sousa, Nuno Palha, Joana Almeida |
dc.subject.por.fl_str_mv |
Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin Science & Technology |
topic |
Behaviour Retinoids Norepinephrine Thyroid hormone Thyroxine Transthyretin Science & Technology |
description |
Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 2004-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/1657 |
url |
http://hdl.handle.net/1822/1657 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Journal of neurochemistry". ISSN 0022-3042. 88 (2004) 1052–1058. 0022-3042 10.1046/j.1471-4159.2003.02309.x 15009661 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303754153918464 |